Spherix advances oncology leadership with novel PD-1 findings and inaugural presence at American Society of Clinical Oncology (ASCO) Annual Meeting 2026. GlobeNewswire | Spherix Global Insights Today at 7:51am PDT Exton, PA, April 29, 2026 (GLOBE NEWSWIRE) - Breadth of physician-driven research underscores emerging trends in oncology as three abstracts are accepted at ASCO 2026: * Operational and clinical drivers of subcutaneous PD-1/PD-L1 inhibitor adoption: A mixed-methods analysis of U.S. oncology practice patterns. * Tumor-specific drivers of PD-1/PD-L1 inhibitor brand preference in NSCLC, melanoma, and renal cell carcinoma: A U.S. oncologist perspective. * Treatment decision-making after CAR-T and bispecific antibody therapy in relapsed/refractory multiple myeloma: Real-world perspectives from U.S. hematologist/oncologists. Spherix Global Insights continues to expand its presence in oncology market intelligence with the release of new findings from its RealTime Dynamix(TM) service focused on PD-1 inhibition in solid tumors, alongside the company's acceptance of three abstracts at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, including one poster presentation, coauthored with Dr. Kimberly Ku of Illinois CancerCare. Together, these milestones underscore both the breadth of Spherix's oncology research portfolio and the growing impact of its physician-derived insights on the broader oncology community. The latest RealTime Dynamix(TM) research, based on a survey of more than 100 U.S. oncologists, highlights a rapidly evolving PD-1 landscape marked by increasing overall utilization, meaningful shifts in route of administration, and emerging complexities in real-world treatment decision-making. Across tumor types, oncologists report that use of PD-1 inhibitor regimens is expected to grow over the next six months, reinforcing the class's continued central role in solid tumor management. At the same time, the data reveal a notable transition from traditional intravenous administration toward subcutaneous options. While intravenous regimens remain foundational - often serving as the preferred starting point - physicians increasingly signal a willingness to adopt subcutaneous alternatives, particularly in maintenance settings where convenience and efficiency are more highly valued. Importantly, this shift is not without friction. Spherix findings suggest that while uptake of subcutaneous PD-1 inhibitors is accelerating, particularly in monotherapy settings, utilization may be more limited in combination regimens due to logistical challenges and access considerations encountered in real-world practice. These dynamics highlight a nuanced adoption curve, where clinical enthusiasm is tempered by operational realities. The competitive landscape remains highly differentiated by tumor type. Pembrolizumab (Keytruda, Merck) continues to lead across multiple non-small cell lung cancer (NSCLC) segments and renal cell carcinoma (RCC), while nivolumab (Opdivo, Bristol Myers Squibb) maintains a strong position in melanoma. However, the introduction of subcutaneous formulations is reshaping share dynamics within brands, with meaningful internal shifts from intravenous to subcutaneous use projected across key indications in the coming months. Beyond branded therapies, Spherix research points to a growing awareness of PD-1 biosimilars in development, though physician visibility into actual product selection remains limited. Oncologists largely recognize the value of biosimilars - particularly in high-volume settings such as NSCLC - yet report that treatment decisions are often dictated at the institutional or payer level, reducing direct physician control over brand choice. Collectively, these findings illustrate a market in transition, where innovation in formulation, evolving treatment strategies, and cost considerations are converging to shape the next phase of PD-1 utilization. Spherix's upcoming presence at ASCO 2026 builds on this momentum. The company's three accepted abstracts, including a poster presentation, reflect the depth and rigor of its oncology research and mark a significant milestone as Spherix brings its real-world evidence and physician insights to one of the field's most prominent global stages for the first time. The accepted research spans key areas of oncology, further reinforcing Spherix's commitment to delivering timely, actionable insights that inform strategic decision-making across the healthcare ecosystem. By pairing robust primary research with deep therapeutic expertise, Spherix continues to provide a uniquely comprehensive view of rapidly evolving markets. As the oncology landscape grows increasingly complex, Spherix remains focused on illuminating the intersection of clinical innovation and real-world practice - equipping stakeholders with the clarity needed to navigate change and anticipate what comes next. About RealTime Dynamix(TM) RealTime Dynamix(TM) is an independent service providing strategic guidance through quarterly or semiannual reports, which include market trending and a fresh infusion of event-driven and variable content with each wave. The reports provide an unbiased view of the competitive landscape within rapidly evolving specialty markets, fueled by robust HCP primary research and its in-house team of experts. About Spherix Global Insights Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle. The seasoned team of Spherix experts provides an unbiased and holistic view of the landscape within rapidly evolving specialty markets, including dermatology, gastroenterology, rheumatology, nephrology, neurology, ophthalmology, and hematology. Spherix clients stay ahead of the curve with the perspective of the extensive Spherix Physician Community. As a trusted advisor and industry thought leader, Spherix's unparalleled market insights and advisory services empower clients to make better decisions and unlock opportunities for growth. To learn more about Spherix Global Insights, visit spherixglobalinsights.com or connect through LinkedIn. For more details on Spherix's primary market research reports and interactive dashboard offerings, visit or register here: https://clientportal.spherixglobalinsights.com Spherix Global Insights Contacts Sarah Hendry, Hematology/Oncology Franchise Head Sarah Hendry Spherix Global Insights 484-879-4284 [email protected] This is a paid placement. For further inquiries, please contact GlobeNewswire directly.

Spherix Global Insights has launched a new Market Access suite of services to provide biopharma manufacturers with data-driven insights across payer strategy, key account dynamics and patient services optimisation. The expansion builds on the company's physician and patient research expertise. The services address the growing complexity of coverage and reimbursement decisions, which increasingly influence prescribing behaviour and brand uptake. Rising pricing scrutiny, evolving regulations and tightening utilisation management have heightened the need for visibility into how organised customers evaluate therapies. Spherix's Market Access offerings are based on primary research and relationships with national and regional payer organisations, Medicare and Medicaid plans, and integrated delivery networks. The services span four interconnected lines covering benefit design trends, policy forecasting, account prioritisation and field execution strategies.

Spherix Global Insights launches Market Dynamix(TM): PD-1 Inhibition in Solid Tumors, delivering a comprehensive assessment of biosimilar and Subcutaneous PD-1 market dynamics across key oncology indications. October 31, 2025 10:37 ET | Source: Spherix Global Insights EXTON, PA, Oct. 31, 2025 (GLOBE NEWSWIRE) - Spherix Global Insights has announced the launch of its latest Market Dynamix(TM) service, PD-1 Inhibition in Solid Tumors (US) 2025, providing an in-depth analysis and advisory services for the evolving immuno-oncology landscape as the next wave of PD-1 biosimilars and subcutaneous (SC) formulations rapidly approach market entry. As leading PD-1 inhibitors, including Merck's Keytruda (pembrolizumab) and BMS' Opdivo (nivolumab), approach loss of exclusivity, Spherix's newest Market Dynamix(TM) study explores physician perceptions, anticipated prescribing shifts, and market readiness for both biosimilar and novel formulation competition within major tumor types, including non - small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), and other top solid tumor indications. The inaugural 2025 edition of Market Dynamix(TM): PD-1 Inhibition in Solid Tumors will integrate quantitative insights from 100 U.S.-based oncologists with Spherix's established market tracking and pipeline intelligence. The research will assess both current treatment algorithms and forward-looking expectations surrounding two critical developments reshaping the checkpoint inhibitor class: * Biosimilar PD-1 inhibitors (e.g., Amgen's ABP-206 nivolumab biosimilar): Evaluating oncologist familiarity, perceived clinical equivalence, adoption intent, and expected impact on practice economics and patient access. * Subcutaneous PD-1 formulations (e.g., Merck's Keytruda QLEX): Exploring attitudes toward convenience, patient and workflow advantages, and anticipated shifts in site-of-care dynamics. * PD-1 brand positioning and share forecasts over the next 12 months. * The evolving influence of biomarker testing requirements (PD-L1, MSI, TMB) on treatment selection. * Barriers and facilitators shaping uptake of new PD-1 entrants. * Future treatment preferences and unmet needs in immuno-oncology delivery. With PD-1 inhibitors continuing to dominate immuno-oncology care, the emergence of biosimilars and SC delivery formats represents a major inflection point for manufacturers, providers, and payers. Spherix's analysis delivers actionable intelligence and advisory services to inform commercial planning, lifecycle management, and competitive positioning across the solid tumor immunotherapy landscape. In 2026, this tracking will expand with RealTime Dynamix(TM): PD-1 Inhibition in Solid Tumors (US) - a quarterly series designed to keep stakeholders up to date on prescriber perceptions, competitive dynamics, and the rapidly evolving PD-1 inhibitor market. reporting cadence to keep you up to date on the evolving market. About Market Dynamix(TM) Market Dynamix(TM) is an independent, data-driven service focused on understanding the evolving dynamics of specialty markets poised for disruption. Leveraging quantitative and qualitative research, the service evaluates current treatment approaches, unmet needs, and likely impact of pipeline agents over a three-to-five-year horizon. RealTime Dynamix(TM) is an independent service providing strategic guidance through quarterly or semiannual reports, which include market trending and a fresh infusion of event-driven and variable content with each wave. The reports provide an unbiased view of the competitive landscape within rapidly evolving specialty markets, fueled by robust HCP primary research and our in-house team of experts. About Spherix Global Insights Spherix is a leading independent market intelligence and advisory firm that delivers commercial value to the global life sciences industry, across the brand lifecycle. The seasoned team of Spherix experts provides an unbiased and holistic view of the landscape within rapidly evolving specialty markets, including dermatology, gastroenterology, rheumatology, nephrology, neurology, ophthalmology, and hematology. Spherix clients stay ahead of the curve with the perspective of the extensive Spherix Physician Community. As a trusted advisor and industry thought leader, Spherix's unparalleled market insights and advisory services empower clients to make better decisions and unlock opportunities for growth. To learn more about Spherix Global Insights, visit spherixglobalinsights.com or connect through LinkedIn. For more details on Spherix's primary market research reports and interactive dashboard offerings, visit or register here: https://clientportal.spherixglobalinsights.com NOTICE: All company, brand or product names in this press release are trademarks of their respective holders. The findings and opinions expressed within are based on Spherix Global Insight's analysis and do not imply a relationship with or endorsement of the companies or brands mentioned in this press release.