Aether Biomachines

Aether Biomachines

Engineering enzymes for custom biocatalysis

Overview

Aether Biomachines engineers enzymes for clients to enable the production of complex and innovative products at lower costs. Its core product is a suite of engineered biocatalysts designed for a growing range of chemical processes, created by exploring search space of enzyme sequences with a proprietary, massively parallel hardware platform. This technology generates very large data sets and a searchable index of trillions of enzymes, allowing rapid design of enzymes for a client’s preferred timeline. The company differentiates itself by being able to search sequence space for novel biocatalysts and by running high-throughput experiments that produce data far larger than competitors, enabling high-value contracts and selective client engagement. Its goal is to drive a new industrial revolution by mapping enzymes like Google maps maps the internet—creating an expandable, searchable catalog of biocatalysts that unlock cheaper, more versatile manufacturing for multiple industries.

About Aether Biomachines

Simplify's Rating
Why Aether Biomachines is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

Biotechnology

Company Size

51-200

Company Stage

Grant

Total Funding

$64.1M

Headquarters

Menlo Park, California

Founded

2017

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Simplify's Take

What believers are saying

  • Seven protein classes address metal refining, PFAS breakdown, carbon capture, pharmaceutical manufacturing.
  • Henkel Corporation partnership signals industrial enzyme applications in adhesives and materials.
  • Defense and aerospace demand for RapidPrint filament supports high-value contract growth.

What critics are saying

  • Profluent Bio's ProGen generates proteins 100X more effectively, eroding Aether's AI advantage.
  • OpenAI's protein folding model commoditizes Aether's proprietary dataset and competitive moat.
  • RapidPrint filament fails FAA certification for aerospace, halting defense sector sales.

What makes Aether Biomachines unique

  • Proprietary high-throughput robotic lab generates datasets orders of magnitude larger than competitors.
  • Protein Function Model discovers novel proteins with searchable, predictable, scalable functions.
  • AI-designed materials print 10X faster, 2X stronger than industry benchmarks for aerospace.

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Funding

Total Funding

$64.1M

Above

Industry Average

Funded Over

4 Rounds

Grant funding comparison data is currently unavailable. We're working to provide this information soon!
Grant Funding Comparison
Coming Soon

Growth & Insights and Company News

Headcount

6 month growth

4%

1 year growth

-4%

2 year growth

-2%
The Associated Press
Feb 6th, 2026
Aethl Bio appoints neurosurgeon Dr Joseph Maroon to scientific advisory board

Aethl Bio, a Pittsburgh-based biotechnology company, has appointed Dr Joseph Maroon to its Scientific Advisory Board. Dr Maroon is a clinical professor of neurological surgery at UPMC, long-time neurosurgeon for the Pittsburgh Steelers, and co-developer of ImPACT, the widely used concussion assessment tool in sports medicine. The appointment strengthens Aethl Bio's scientific leadership as it develops oxygen-based solutions for chronic wound care and wellness applications. Dr Maroon brings expertise in brain injury recovery, oxygen-based therapies including hyperbaric oxygen therapy, and metabolic health. CEO Carmelo Montalvo described the appointment as validation of the company's platform and mission. Aethl Bio is currently advancing pre-clinical validation, regulatory strategy and clinical partnerships for its technology designed to deliver biologically relevant oxygen to support tissue repair.

Business Wire
Dec 4th, 2025
Aether Biomachines Raises $15M to Reindustrialize America with AI-Designed Proteins

Aether Biomachines, the company reindustrializing America by turning AI-designed proteins into real-world solutions, today announced an additional $15 millio...

FinSMEs
Dec 3rd, 2025
Aether Biomachines Raises $15M in Funding

Aether Biomachines raises $15M in funding. Aether Biomachines, a San Francisco, CA-based company turning AI-designed proteins into real-world solutions, raised $15M in funding. The round was led by Tribe Capital, with participation from new and existing investors including Natural Capital, Henkel Corporation, Resilience Reserve, Shrug Capital, 4DX Ventures, Unless Partners, and Radicle Impact. The company intends to use the funds to expand its Protein Function Model to rapidly design and optimize proteins for industrial and environmental applications, scale its first commercial materials products, and accelerate partnerships with companies looking to apply its AI-powered proteins across manufacturing, sustainability, and national security. Led by CEO and Founder Pavle Jeremić, Aether Biomachines is an American artificial intelligence company that discovers proteins with high-impact, real-world applications. At the core of its work is a Protein Function Model that can generate new proteins for novel functions. Aether's AI is being built on an entirely proprietary dataset developed in-house through advanced high-throughput screening and innovative assay technology. The company says that it is already translating its AI innovations into practice, commercializing high-performance materials that can print faster than current industry benchmarks while offering better strength for the defense and aerospace industries.

FinancialContent
Dec 3rd, 2025
Aether Biomachines raises $15M to design AI proteins for industrial manufacturing

Aether Biomachines has raised $15 million in funding led by Tribe Capital, bringing its total funding to $64 million. The company uses AI and high-throughput robotics to design proteins that function as molecular assemblers for industrial applications. Aether's Protein Function Model creates proteins for manufacturing, sustainability and national security purposes. The company has developed seven protein classes with applications including metal refining, breaking down forever chemicals, pharmaceutical manufacturing, plastic recycling and carbon capture. Its AI-designed materials can print ten times faster than current industry standards whilst offering superior strength for defence and aerospace sectors. The funding will expand Aether's protein design capabilities, scale its first commercial materials products and accelerate partnerships across multiple industries. Founded by CEO Pavle Jeremić, the company aims to reduce reliance on global supply chains through domestically produced solutions.

TCT Magazine
Nov 19th, 2025
Aether launches RapidPrint 3D printing filament offering at Formnext

Aether launches RapidPrint 3D printing filament offering at Formnext. A new polymer filament 3D printing offering that promises to 'unlock dramatic acceleration' in the additive manufacturing of high-performance parts has been launched by Aether. Aether describes itself as an American artificial intelligence company that discovers proteins with high-impact, real-world applications. Its RapidPrint technology is said to enable fast print speeds and 'industry-leading mechanical properties', with the company targeting the aerospace, defence and industrial sectors. At Formnext, Aether is demonstrating the capabilities of the technology, as well as its forthcoming 'Ultra Series' of high-strength polymer filaments, on the AON3D Hylo printer. The RapidPrint PA6 CF10 ABX, a modified PA6 with 10% carbon fibre reinforcement, is set to be the first Aether formulation to be released. This material has been engineered for high flow, broad printer compatibility, and excellent surface finish, while 'printing effortlessly between 50-250 mm/s.' With defence and drone manufacturers increasingly relying on additive manufacturing for agile iteration, limited-run production, and field repair, Aether is working to provide material technology that supports high productivity, short development cycles and resilient supply chains. Aether is exhibiting at Formnext from Hall 11.1, Booth E68, with live demos being performed throughout the week.

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