Alector

Alector

Biopharmaceutical R&D for neurodegenerative therapies

Overview

Alector is a biopharmaceutical company that develops therapies for neurodegenerative diseases such as Alzheimer's and Parkinson's. It uses insights from immunology, neurology, and human genetics to create medicines that help the body heal itself. The company focuses on researching and developing novel therapeutic candidates, mainly through early-stage clinical trials to quickly gather disease-specific data and improve the chances of success. Revenue and funding come from partnerships, grants, and eventual product commercialization. Alector aims to advance treatments for unmet medical needs in neurodegenerative diseases by pursuing a pipeline that combines scientific findings with strategic drug development.

About Alector

Simplify's Rating
Why Alector is rated
C
Rated B on Competitive Edge
Rated C on Growth Potential
Rated D+ on Differentiation

Industries

Biotechnology

Healthcare

Company Size

51-200

Company Stage

IPO

Headquarters

San Francisco, California

Founded

2013

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Simplify's Take

What believers are saying

  • Cash was $172.8 million on June 30, 2026, funding operations through 2027.
  • Workforce cuts in 2025 and 2026 lowered R&D and G&A expenses materially.
  • AL137’s IND filing is targeted for Q1 2027, providing a near-term catalyst.

What critics are saying

  • GSK ends its collaboration January 2, 2027, killing $1.5 billion milestones.
  • INFRONT-3 failed in October 2025 and PROGRESS-AD ended in April 2026.
  • AL137 is early-stage; if it fails, Alector becomes a cash-burning shell.

What makes Alector unique

  • Alector pairs human genetics with neuroimmunology to target disease biology, not symptoms.
  • Its ABC platform spans antibodies and siRNA for microglia-driven neurodegeneration.
  • Few peers combine deep progranulin biology, genetic validation, and neurological target discovery.

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Funding

Total Funding

$495.5M

Above

Industry Average

Funded Over

6 Rounds

Post IPO Debt funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Debt Funding Comparison
Coming Soon

Benefits

Flexible Work Hours

Hybrid Work Options

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

-3%

1 year growth

1%

2 year growth

4%
MarketBeat
Aug 6th, 2026
Alector (NASDAQ:ALEC) releases earnings results, beats expectations by $0.02 EPS.

Alector (NASDAQ:ALEC) releases earnings results, beats expectations by $0.02 EPS. August 6, 2026 Key points. * Alector beat quarterly expectations: The biotechnology company reported a loss of $0.21 per share, $0.02 better than analysts' forecast, while revenue of $3.32 million exceeded the $1.43 million consensus estimate. * Shares rose amid heavy trading: Alector stock gained $0.34 to $1.83, with trading volume far above average. Despite strong liquidity, the company remained deeply unprofitable, posting a negative net margin of 680.83%. * Analyst sentiment remains mixed: Alector has an average "Hold" rating and a $3.62 price target, while recent recommendations ranged from "Sell" and "Underweight" to "Overweight." Company insiders sold 115,760 shares over the past 90 days. * MarketBeat previews the top five stocks to own by September 1st. Alector (NASDAQ:ALEC - Get Free Report) announced its quarterly earnings results on Thursday. The company reported ($0.21) earnings per share for the quarter, beating analysts' consensus estimates of ($0.23) by $0.02, FiscalAI reports. The business had revenue of $3.32 million for the quarter, compared to the consensus estimate of $1.43 million. Alector had a negative net margin of 680.83% and a negative return on equity of 295.17%. Alector stock performance. Alector stock traded up $0.34 during midday trading on Thursday, reaching $1.83. 5,702,966 shares of the company's stock were exchanged, compared to its average volume of 484,769. The stock's 50-day simple moving average is $1.69 and its 200 day simple moving average is $2.01. The firm has a market cap of $203.18 million, a price-to-earnings ratio of -1.54 and a beta of 0.60. The company has a debt-to-equity ratio of 0.80, a quick ratio of 5.25 and a current ratio of 5.25. Alector has a 52 week low of $1.09 and a 52 week high of $3.40. Analyst Ratings changes. Several research firms have weighed in on ALEC. Morgan Stanley reiterated an "underweight" rating and set a $2.00 target price on shares of Alector in a report on Monday, May 4th. Wall Street Zen upgraded shares of Alector from a "sell" rating to a "hold" rating in a report on Saturday, May 9th. Weiss Ratings reiterated a "sell (e+)" rating on shares of Alector in a report on Friday, July 31st. Finally, Cantor Fitzgerald upgraded shares of Alector from a "neutral" rating to an "overweight" rating in a report on Wednesday, April 15th. Three investment analysts have rated the stock with a Buy rating, three have issued a Hold rating and two have assigned a Sell rating to the stock. According to MarketBeat, Alector currently has an average rating of "Hold" and an average price target of $3.62. Discover more Business News Stock Profit Calculator MarketBeat Research Tools Insider buying and selling. In other news, CEO Arnon Rosenthal sold 87,216 shares of the business's stock in a transaction that occurred on Tuesday, June 2nd. The stock was sold at an average price of $1.97, for a total transaction of $171,815.52. Following the completion of the sale, the chief executive officer owned 2,367,206 shares in the company, valued at $4,663,395.82. The trade was a 3.55% decrease in their ownership of the stock. The sale was disclosed in a legal filing with the SEC, which is available at this hyperlink. Also, CFO Neil Lindsay Berkley sold 19,360 shares of the company's stock in a transaction on Tuesday, June 2nd. The shares were sold at an average price of $1.97, for a total value of $38,139.20. Following the completion of the transaction, the chief financial officer directly owned 379,900 shares in the company, valued at approximately $748,403. This represents a 4.85% decrease in their ownership of the stock. Additional details regarding this sale are available in the official SEC disclosure. Over the last ninety days, insiders sold 115,760 shares of company stock valued at $227,734. Insiders own 8.30% of the company's stock. Institutional inflows and outflows. A number of institutional investors and hedge funds have recently made changes to their positions in the business. Jane Street Group LLC grew its position in Alector by 4.7% during the first quarter. Jane Street Group LLC now owns 256,551 shares of the company's stock worth $316,000 after buying an additional 11,618 shares in the last quarter. Strs Ohio bought a new stake in shares of Alector during the 1st quarter valued at approximately $126,000. Geode Capital Management LLC increased its holdings in shares of Alector by 1.0% during the second quarter. Geode Capital Management LLC now owns 1,982,068 shares of the company's stock worth $2,775,000 after buying an additional 19,970 shares in the last quarter. Prudential Financial Inc. acquired a new stake in shares of Alector during the second quarter valued at about $30,000. Finally, XTX Topco Ltd boosted its position in Alector by 125.2% during the 2nd quarter. XTX Topco Ltd now owns 73,338 shares of the company's stock worth $103,000 after buying an additional 40,767 shares during the period. Institutional investors and hedge funds own 85.83% of the company's stock. About Alector. Alector is a clinical-stage biotechnology company headquartered in South San Francisco, California. Founded in 2013, the company is focused on discovering and developing immuno-neurology therapies that target the innate immune system to treat a range of neurodegenerative disorders. Alector's approach aims to harness the body's natural defense mechanisms to clear pathological proteins and restore neuronal function in conditions such as Alzheimer's disease and frontotemporal dementia. The company's pipeline includes multiple product candidates in both preclinical and clinical stages, with lead programs AL001 and AL002 advancing in frontotemporal dementia and Alzheimer's disease studies. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Alector, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Alector wasn't on the list. While Alector currently has a Hold rating among analysts, top-rated analysts believe these five stocks are better buys. Discover the 10 Best High-Yield Dividend Stocks for 2026 and secure reliable income in uncertain markets. Download the report now to identify top dividend payers and avoid common yield traps.

Yahoo Finance
May 8th, 2026
Alector reports Q1 loss of $0.21 per share, misses revenue estimates by 65%

Alector reported a first-quarter loss of $0.21 per share, beating the consensus estimate of a $0.35 loss by 40%. This marks the fourth consecutive quarter the biotechnology company has surpassed earnings expectations. The result improved from a loss of $0.41 per share in the same period last year. However, the company missed revenue targets, posting $1.05 million against expectations of $3 million, a 65.13% shortfall. This compares to revenue of $3.67 million in the year-ago quarter. Alector shares have gained 64.7% year-to-date, outperforming the S&P 500's 7.6% gain. Despite the earnings beat, unfavourable estimate revisions have resulted in a Zacks Rank of four, suggesting potential near-term underperformance.

Yahoo Finance
Feb 25th, 2026
Alector beats Q4 expectations with $6.2M revenue, narrows loss to 34 cents per share

Alector, a South San Francisco-based biotechnology company, reported a fourth-quarter loss of $37.3 million, or 34 cents per share, beating analyst expectations of a 39-cent loss. The company posted revenue of $6.2 million, exceeding forecasts of $3.1 million from three analysts surveyed by Zacks Investment Research. For the full year, Alector's loss widened to $142.9 million, or $1.39 per share, with revenue of $21 million. The company's shares closed at $2.39 on Wednesday, up from $1.77 a year earlier.

GlobeNewswire
Jun 3rd, 2025
Alector To Participate In The Goldman Sachs 46Th Annual Global Healthcare Conference

SOUTH SAN FRANCISCO, Calif., June 03, 2025 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a late-stage clinical biotechnology company focused on developing therapies to counteract the devastating progression of neurodegeneration, today announced that management will participate in a fireside chat at the Goldman Sachs 46th Annual Global Healthcare Conference on Tuesday, June 10, 2024, at 8:40 am ET.A live webcast of the fireside chat will be available on the “Events & Presentations” page within the Investors section of the Alector website at http://investors.alector.com. A replay will be available on the Alector website for 90 days following the event.About AlectorAlector is a late-stage clinical biotechnology company focused on developing therapies to counteract the devastating progression of neurodegenerative diseases. Leveraging the principles of genetics, immunology, and neuroscience, the company is advancing a portfolio of genetically validated programs that aim to remove toxic proteins, replace deficient proteins, and restore immune and nerve cell function. Supported by biomarkers, Alector’s product candidates seek to treat a range of indications, such as frontotemporal dementia, Alzheimer’s disease, and Parkinson's disease. The company is also developing Alector Brain Carrier (ABC), a proprietary blood-brain barrier platform, which is being selectively applied to its next-generation product candidates and research pipeline

StockTitan
May 6th, 2025
Alector to Participate in Upcoming Healthcare Conferences

Additionally, Alector will participate in a fireside chat at the H.C. Wainwright 3rd Annual BioConnect Investor Conference in New York on May 20, 2025, at 12:00 p.m. ET.

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