Apellis Pharmaceuticals

Apellis Pharmaceuticals

Develops complement inhibition therapies for diseases

Overview

Apellis Pharmaceuticals develops therapies that target the complement system, a part of the immune system involved in inflammation and disease. The company focuses on complement inhibition to treat rare and debilitating conditions with unmet medical needs. Its approach centers on therapies that precisely modulate the complement cascade to help patients. Apellis went public in 2017 to fund its research and development efforts, and in 2025 it formed a strategic partnership with Sobi to sell ex-US royalties on its drug Aspaveli for up to $300 million, providing capital and expanding global reach. Compared with competitors, Apellis pursues targeted complement modulation and leverages strategic partnerships and royalties to support its growth. The company's goal is to advance effective, targeted treatments that improve the lives of patients worldwide by addressing diseases driven by the complement system.

Significant Headcount Growth

About Apellis Pharmaceuticals

Simplify's Rating
Why Apellis Pharmaceuticals is rated
C+
Rated C on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

501-1,000

Company Stage

IPO

Headquarters

Waltham, Massachusetts

Founded

2008

People at Apellis Pharmaceuticals

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Simplify's Take

What believers are saying

  • Biogen acquisition adds $689M revenue portfolio and accelerates nephrology expansion.
  • Sobi royalty deal provided $275M upfront payment boosting 2025 net income.
  • Projected mid-to-high teens revenue growth through 2028 supports operational funding.

What critics are saying

  • Biogen $5.6B acquisition closing Q2 2026 eliminates strategic independence permanently.
  • CVR upside fails if Syfovre misses $1.5B sales threshold between 2027-2031.
  • Syfovre sales plateau risk from Novartis competitors and insurance limits below $1.5B.

What makes Apellis Pharmaceuticals unique

  • Targets the complement system with precise inhibition therapies for rare diseases.
  • Flagship drug Syfovre leads geographic atrophy treatment with $587M 2025 revenue.
  • Empaveli gained 5% kidney disease market share after July 2025 FDA approval.

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Funding

Total Funding

$7.3B

Above

Industry Average

Funded Over

13 Rounds

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Acquisition Funding Comparison
Coming Soon

Benefits

401(k) Retirement Plan

401(k) Company Match

Flexible Work Hours

Remote Work Options

Hybrid Work Options

Disability Insurance

Life Insurance

Family Planning Benefits

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

16%

1 year growth

17%

2 year growth

15%
Apellis Pharmaceuticals
Apr 1st, 2026
Apellis Pharmaceuticals Announces Closing of its Initial Public Offering | Apellis Pharmaceuticals, Inc.

CRESTWOOD, Ky., Nov. 13, 2017 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds to treat disease through the inhibition of the complement system, today announced the closing of its initial public offering of 10,714,000 shares of common stock at a public offering price of $14.00 per share. The total gross proceeds to Apellis were approximately $150.0 million, before deducting underwriting discounts and commissions and expenses payable by Apellis. All of the shares were sold by Apellis. In addition, Apellis granted the underwriters a 30-day option to purchase up to 1,607,100 additional shares of common stock at the public offering price, less underwriting discounts and commissions, to cover over-allotments, if any. The shares commenced trading on the NASDAQ Global Select Market under the ticker symbol “APLS” on Thursday, November 9, 2017.

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