Arvinas

Arvinas

Clinical-stage biopharma developing PROTAC degraders

Overview

Arvinas develops PROTAC-based protein degraders in clinical-stage biopharmaceutical programs aimed at diseases driven by harmful proteins, including cancer and neurodegenerative disorders. Its PROTAC platform works by linking a disease-causing protein to an E3 ligase, tagging the target for degradation by the cell’s proteasome rather than merely inhibiting it. Revenue comes from partnerships, collaborations, and licensing deals with other pharma companies, as well as the potential commercialization of its drug candidates. The company’s goal is to improve patient outcomes by delivering targeted, mechanism-based therapies and advancing its drug candidates through discovery, development, and potential commercialization.

About Arvinas

Simplify's Rating
Why Arvinas is rated
B
Rated A on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

201-500

Company Stage

IPO

Headquarters

New Haven, Connecticut

Founded

2013

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Simplify's Take

What believers are saying

  • Rigel closed VEPPANU licensing on June 16, 2026, paying Arvinas $35 million upfront.
  • Arvinas reported $249.7 million revenue and $567.9 million cash on August 4, 2026.
  • Management projects runway into second-half 2028 while advancing ARV-102, ARV-393, and ARV-027.

What critics are saying

  • ARV-102 stayed under clinical hold after October 1, 2026 biomarker presentations.
  • Arvinas cut 15% of staff in 2025 and completed restructuring by Q2 2026.
  • One failed readout can erase Arvinas's remaining standalone value.

What makes Arvinas unique

  • Arvinas secured the first FDA-approved PROTAC, VEPPANU, on May 1, 2026.
  • ARV-102 crosses the blood-brain barrier for Parkinson’s and PSP, broadening PROTAC biology.
  • ARV-393, ARV-027, and ARV-6723 span lymphoma, SBMA, and solid-tumor oncology.

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Funding

Total Funding

$589M

Above

Industry Average

Funded Over

5 Rounds

Private Placement VC funding comparison data is currently unavailable. We're working to provide this information soon!
Private Placement VC Funding Comparison
Coming Soon

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

↑ 1%

1 year growth

↑ 0%

2 year growth

↑ 1%
U.S. Securities and Exchange Commission
Oct 4th, 2026
arvn-10k_20181231.htm

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Arvinas
Oct 1st, 2026
Arvinas to present novel Biomarker Data from the Phase 1 clinical trial for ARV-102, a PROTAC LRRK2 Degrader, at the 2026 International Congress of Parkinson's Disease and Movement Disorders(R).

Arvinas to present novel Biomarker Data from the Phase 1 clinical trial for ARV-102, a PROTAC LRRK2 Degrader, at the 2026 International Congress of Parkinson's Disease and Movement Disorders(R). October 1, 2026 NEW HAVEN, Conn., Oct. 01, 2026 (GLOBE NEWSWIRE) - Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today announced that novel biomarker data from a Phase 1 clinical trial of ARV-102 in participants with Parkinson's disease will be presented as late-breaking oral and poster presentations at the 2026 International Congress of Parkinson's Disease and Movement Disorders(R)(MDS), taking place October 4-8, 2026, in Seoul, Korea. ARV-102 is Arvinas' investigational, orally bioavailable PROteolysis TArgeting Chimera (PROTAC) degrader designed to cross the blood-brain barrier and target leucine-rich repeat kinase 2 (LRRK2), a multifunctional protein that has been implicated in Parkinson's disease and progressive supranuclear palsy (PSP). The presentation details are as follows: Presentation Title: Phase 1 Study of ARV-102, a PROTAC LRRK2 Degrader, in Parkinson's Disease: Oculomotor and Biomarker Data Session Number: 12 Session Title: Late-Breaking Abstracts: Parkinson's Disease Session Type: Oral Session Location: Conference Room E3, 3rd Floor Presentation Number: LBA 15 Presentation Order: 3 Presentation Duration: 5 minutes Date: Wednesday, October 7 Session Time: 12:30 - 13:30 ET Presentation Title: Phase 1 Study of ARV-102, a PROTAC LRRK2 Degrader, in Parkinson's Disease: Oculomotor and Biomarker Data Session Type: E-Poster Session Location: E-Poster Hall, online Presentation Number: LBA 15 Additional information including abstracts can be found on the 2026 MDS Congress website. About ARV-102 ARV-102 is an investigational, orally bioavailable PROteolysis TArgeting Chimera (PROTAC) designed to cross the blood-brain barrier and specifically target and degrade leucine-rich repeat kinase (LRRK2), a large, multidomain scaffolding kinase with GTPase activity. Increased activity and over expression of LRRK2 have been implicated in the pathogenesis of neurological diseases, including LRRK2 genetic and idiopathic Parkinson's disease and progressive supranuclear palsy (PSP). ARV-102 has been evaluated in a Phase 1 clinical trial in healthy volunteers and in patients with Parkinson's disease. About Arvinas Arvinas (Nasdaq: ARVN) is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases. Through its PROteolysis TArgeting Chimera (PROTAC) protein degrader platform, Arvinas is pioneering the development of protein degradation therapies designed to harness the body's natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. Arvinas, with its partner Pfizer, developed the first U.S. Food and Drug Administration (FDA)-approved PROTAC, a type of heterobifunctional protein degrader, which has been outlicensed to Rigel Pharmaceuticals, Inc. for exclusive global development, manufacturing, and commercialization. Arvinas is currently progressing multiple investigational drugs through clinical development programs, including ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-102, targeting LRRK2 for neurodegenerative disorders; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle for spinal-bulbar muscular atrophy, also known as Kennedy's disease; and ARV-6723, targeting hematopoietic progenitor kinase 1 (HPK1) for advanced solid tumors. Arvinas has also advanced ARV-806, targeting Kirsten rat sarcoma (KRAS) G12D for solid tumors, in the clinic, and previously announced plans to seek an out-licensing agreement for any additional clinical trials of ARV-806, including dose expansion or combination clinical trials. Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www.arvinas.com and connect on LinkedIn and X. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties, including statements regarding: the potential of ARV-102, including its degradation of leucine-rich repeat kinase 2 ("LRRK2"), and its potential treatment of neurodegenerative diseases, including Parkinson's disease and progressive supranuclear palsy ("PSP"); and Arvinas' plans with respect to its clinical development programs. All statements, other than statements of historical fact, contained in this press release, including statements regarding Arvinas' strategy, development plans, future operations, prospects, plans, and objectives of management and the statements identified in the prior paragraph, are forward-looking statements. The words "ability," "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "potential," "target," "goal," "aim," "whether," "will," "would," "could," "reliance," "should," "look forward," "seek," "continue," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Arvinas may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on such forward-looking statements. Actual results or events could differ materially from the plans, intentions, and expectations disclosed in the forward-looking statements Arvinas makes as a result of various risks and uncertainties, including but not limited to: whether Arvinas will be able to successfully conduct and complete development for its product candidates, including ARV-102, on its current timelines or at all; risks related to clinical trial results and the interpretation thereof, including with respect to ARV-102; Arvinas' ability to protect its intellectual property portfolio; Arvinas' reliance on third parties; whether Arvinas will be able to raise capital when needed; whether Arvinas' cash and cash equivalents will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; and other important factors discussed in the "Risk Factors" section of Arvinas' Annual Report on Form 10-K for the year ended December 31, 2025 and subsequent other reports filed with the U.S. Securities and Exchange Commission. The forward-looking statements contained in this press release reflect Arvinas' current views with respect to future events, and Arvinas assumes no obligation to update any forward-looking statements, except as required by applicable law. These forward-looking statements should not be relied upon as representing Arvinas' views as of any date subsequent to the date of this release.

MarketBeat
Sep 16th, 2026
Arvinas, Inc. $ARVN shares purchased by Squarepoint Ops LLC.

Arvinas, Inc. $ARVN shares purchased by Squarepoint Ops LLC. September 16, 2026 Key points. * Squarepoint Ops LLC increased its Arvinas stake by 760.3% in the second quarter, reaching 201,822 shares valued at approximately $1.68 million. Institutional investors and hedge funds collectively own 95.19% of ARVN. * Arvinas reported strong quarterly results, with $249.7 million in revenue - up 1,014.7% year over year - and earnings of $2.58 per share, exceeding analyst expectations. * ARVN shares opened at $8.26, while analysts maintained a consensus "Hold" rating and an average price target of $14.17; the company's CFO separately sold shares under a pre-arranged plan to cover tax obligations. * Interested in Arvinas? Here are five stocks we like better. Squarepoint Ops LLC boosted its position in Arvinas, Inc. (NASDAQ:ARVN - Free Report) by 760.3% during the second quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The fund owned 201,822 shares of the company's stock after buying an additional 178,362 shares during the period. Squarepoint Ops LLC owned approximately 0.31% of Arvinas worth $1,677,000 as of its most recent filing with the Securities & Exchange Commission. Other institutional investors and hedge funds have also bought and sold shares of the company. BlackRock Inc. acquired a new stake in shares of Arvinas in the second quarter worth $63,232,000. Armistice Capital LLC grew its position in Arvinas by 50.0% during the 4th quarter. Armistice Capital LLC now owns 1,800,000 shares of the company's stock worth $21,348,000 after purchasing an additional 600,000 shares during the period. Nantahala Capital Management LLC acquired a new stake in Arvinas during the 2nd quarter worth about $2,493,000. Man Group plc purchased a new position in shares of Arvinas during the 2nd quarter valued at about $2,128,000. Finally, Bank of New York Mellon Corp purchased a new position in shares of Arvinas during the 2nd quarter valued at about $2,119,000. 95.19% of the stock is currently owned by institutional investors and hedge funds. Insider transactions at Arvinas. In other Arvinas news, CFO Andrew Saik sold 5,696 shares of the business's stock in a transaction that occurred on Wednesday, June 24th. The stock was sold at an average price of $8.16, for a total transaction of $46,479.36. Following the completion of the sale, the chief financial officer directly owned 187,432 shares in the company, valued at approximately $1,529,445.12. The trade was a 2.95% decrease in their position. The transaction was disclosed in a filing with the Securities & Exchange Commission, which is accessible through this hyperlink. The transaction was executed under a pre-arranged Rule 10b5-1 trading plan. The sale was made to cover tax withholding obligations related to the vesting of equity awards. 7.30% of the stock is currently owned by insiders. Arvinas trading down 1.7%. Shares of ARVN opened at $8.26 on Wednesday. Arvinas, Inc. has a 12 month low of $6.97 and a 12 month high of $14.51. The stock's 50 day moving average is $8.73 and its two-hundred day moving average is $9.53. The firm has a market cap of $532.94 million, a P/E ratio of 82.61 and a beta of 1.75. Discover more Market Cap Calculator Space Stocks Report Arvinas (NASDAQ:ARVN - Get Free Report) last announced its earnings results on Tuesday, August 4th. The company reported $2.58 earnings per share for the quarter, topping the consensus estimate of ($0.37) by $2.95. Arvinas had a return on equity of 1.91% and a net margin of 2.94%.The business had revenue of $249.70 million during the quarter, compared to the consensus estimate of $60.71 million. During the same period in the prior year, the company posted ($0.84) EPS. The business's quarterly revenue was up 1014.7% on a year-over-year basis. Equities research analysts forecast that Arvinas, Inc. will post 0.05 EPS for the current year. Wall Street analyst weigh in. ARVN has been the topic of a number of recent research reports. Zacks Research downgraded Arvinas from a "strong-buy" rating to a "hold" rating in a research note on Thursday, September 3rd. Evercore set a $14.00 price target on Arvinas in a research report on Monday, August 10th. Weiss Ratings raised Arvinas from a "sell (e+)" rating to a "sell (d)" rating in a report on Thursday, August 13th. BTIG Research restated a "buy" rating and issued a $18.00 price objective on shares of Arvinas in a research report on Tuesday, August 4th. Finally, Citigroup dropped their price objective on shares of Arvinas from $24.00 to $21.00 and set a "buy" rating on the stock in a research note on Monday, August 10th. Five equities research analysts have rated the stock with a Buy rating, four have assigned a Hold rating and two have assigned a Sell rating to the stock. Based on data from MarketBeat.com, the stock has a consensus rating of "Hold" and a consensus price target of $14.17. About Arvinas. Arvinas, Inc is a clinical-stage biopharmaceutical company focused on developing medicines that selectively remove disease-causing proteins from cells. The company's approach, known as targeted protein degradation, uses proprietary PROTAC technology to direct specific proteins to the cell's natural disposal machinery. Arvinas applies this platform primarily to cancer and other serious diseases in which abnormal or unwanted proteins contribute to disease progression. Arvinas' pipeline has included vepdegestrant, formerly known as ARV-471, an investigational oral estrogen receptor degrader being developed for patients with estrogen receptor-positive, HER2-negative breast cancer. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Before you consider Arvinas, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Arvinas wasn't on the list. While Arvinas currently has a Hold rating among analysts, top-rated analysts believe these five stocks are better buys. The AI boom is creating opportunities across semiconductors, cloud computing, enterprise software, infrastructure, cybersecurity, and automation. Inside this report, you'll find 10 companies positioned to benefit as artificial intelligence moves from hype to real-world deployment and becomes a core growth driver for corporate America. Continue following MarketBeat

GlobeNewswire
Sep 3rd, 2026
Arvinas to participate in upcoming investor conferences.

Arvinas to participate in upcoming investor conferences. September 03, 2026 16:01 ET | Source: Arvinas Inc. NEW HAVEN, Conn., Sept. 03, 2026 (GLOBE NEWSWIRE) - Arvinas, Inc. (Nasdaq: ARVN) ("Arvinas" or the "Company"), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today announced that that management will participate in fireside chats at the following upcoming investor conferences: * Wells Fargo Healthcare Conference on Tuesday, September 8, 2026, at 1:30 p.m. ET; webcast available here. * Cantor Global Healthcare Conference on Thursday, September 10, 2026, at 2:10 p.m. ET; webcast available here. * Morgan Stanley Annual Global Healthcare Conference on Wednesday, September 16, 2026, at 9:15 a.m. ET; webcast available here. All webcasts will also be available in the Events and Presentations section of the Company's website. About Arvinas Arvinas (Nasdaq: ARVN) is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases. Through its PROTAC (PROteolysis TArgeting Chimera) protein degrader platform, Arvinas is pioneering the development of protein degradation therapies designed to harness the body's natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. Arvinas, with its partner Pfizer, developed the first U.S. Food and Drug Administration (FDA)-approved PROTAC, a type of heterobifunctional protein degrader, which has been outlicensed to Rigel Pharmaceuticals, Inc. for exclusive global development, manufacturing, and commercialization. Arvinas is currently progressing multiple investigational drugs through or into clinical development programs, including ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-102, targeting LRRK2 for neurodegenerative disorders; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle for spinal-bulbar muscular atrophy, also known as Kennedy's disease; and ARV-6723, targeting HPK1 for advanced solid tumors. Arvinas has also advanced ARV-806, targeting KRAS G12D for solid tumors, in the clinic, and previously announced plans to seek an out-licensing agreement for any additional clinical trials of ARV-806, including dose expansion or combination clinical trials. Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www.arvinas.com and connect on LinkedIn and X.

Yahoo Finance
Aug 11th, 2026
Arvinas shifts focus to Phase I programmes after first PROTAC degrader approval

Arvinas reported progress on several strategic initiatives during its second quarter 2026 earnings call. The company achieved three key milestones this year: securing the first FDA approval for a PROTAC degrader, VEPPANU; completing an out-licensing deal for VEPPANU with Rigel Pharmaceuticals; and deciding to advance its KRAS G12D programme, ARV-806, only through a partnership. President and Chief Executive Officer Randy Teel said the company is focusing on advancing transformational improvements for patients through continued innovation and disciplined execution. The strategic decisions have positioned Arvinas to concentrate fully on its Phase I clinical programmes in oncology and neurology. The company determined that ARV-806 requires investment inconsistent with its current capital allocation strategy, though it believes the programme has potential as a meaningful treatment option.

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