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BigHat Biosciences designs and develops antibody therapies by combining machine learning with synthetic biology. Its Milliner platform integrates a wet-lab workflow with AI to discover, engineer, and fully characterize hundreds of recombinant antibodies each week, enabling rapid development of safer and more effective treatments for hard-to-treat diseases such as certain infections and cancers. Unlike traditional antibody discovery, Milliner provides end-to-end screening, purification, and characterization in a high-throughput, weekly workflow, speeding up the path from concept to candidate. The company differentiates itself through its integrated platform that couples ML-driven design with synthetic biology experimentation, a focus on challenging diseases, and a culture that emphasizes work-life balance. Its goal is to deliver faster, safer antibody therapies to patients by expanding access to rapid discovery and engineering capabilities for healthcare providers and patients alike.
Industries
Data & Analytics
AI & Machine Learning
Biotechnology
Healthcare
Company Size
51-200
Company Stage
Series B
Total Funding
$99.3M
Headquarters
San Carlos, California
Founded
2019
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Total Funding
$99.3M
Above
Industry Average
Funded Over
3 Rounds
Industry standards
Professional Development Budget
BigHat Biosciences raised $124 million in Series B funding led by S32 on April 28, 2025, with a pre-money valuation of $180 million. Participants included Amgen, Bristol-Myers Squibb, Quadrille Capital, Gaingels, GRIDS Capital, Axial, Quain Investments, Andreessen Horowitz, 8VC, AME Cloud Ventures, and Kevin Moore.
Co-founder Mark DePristo has stepped down as CEO of Bighat Biosciences Inc. and is succeeded by fellow co-founder Peyton Greenside, who was president and CSO.
The Danish company Adcendo and Chinese company Multitude Therapeutics entered into a $1 billion deal to develop ADCs for the treatment of cancer; and in August, the FDA lifted a partial hold on a Phase 1 trial evaluating an ADC candidate developed by MediLink Therapeutics and BioNTech for the treatment of advanced or metastatic non-small cell lung cancer and breast cancer.
BigHat obtains access to Synaffix's site-specific ADC technology platform, and plans to combine Synaffix technology with its advanced ML antibody design platform to develop a new ADC pipeline
Similarly, AbbVie is collaborating with BigHat Biosciences to develop next-generation antibody therapeutics using the Milliner platform, focusing on oncology and neuroscience.
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Industries
Data & Analytics
AI & Machine Learning
Biotechnology
Healthcare
Company Size
51-200
Company Stage
Series B
Total Funding
$99.3M
Headquarters
San Carlos, California
Founded
2019
Find jobs on Simplify and start your career today