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Cogent Biosciences

Develops small-molecule therapies for rare diseases

Overview

Cogent Biosciences develops small molecule therapies for rare, genetically driven diseases. Its work centers on discovering and advancing compounds that can address conditions with limited treatment options, using a research-driven approach to guide drug discovery and development through clinical trials. The lead candidate, CGT9486, is progressing in three clinical trials planned for this year, alongside ongoing work in collaboration with partners. The company differentiates itself through its focus on genetically defined diseases, its emphasis on targeted small molecules, and its strategy of advancing candidates via internal science and partnerships, supported by a strong financial position that includes a cash reserve of $242.2 million. Cogent’s goal is to bring effective therapies to patients with unmet needs by progressing its drug candidates toward potential commercialization and forming strategic collaborations to maximize development and access.

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About Cogent Biosciences

Simplify's Rating
Why Cogent Biosciences is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

201-500

Company Stage

IPO

Headquarters

Cambridge, MA

Founded

2014

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What believers are saying

  • FDA accepted GIST NDA with Priority Review on May 28, 2026.
  • AdvSM NDA accepted September 15, 2026, extending the launch runway into 2027.
  • Preclinical AACR 2026 data support CGT1263 and CGT4255 as next assets.

What critics are saying

  • GIST and NonAdvSM PDUFAs on November 30 and December 30, 2026.
  • Approval dependence on bezuclastinib makes Cogent existentially vulnerable to one FDA rejection.
  • Q2 2026 net loss hit $96.4 million, accelerating dilution or launch-execution pressure.

What makes Cogent Biosciences unique

  • Bezuclastinib produced 16.5-month median PFS in PEAK on May 30, 2026.
  • Cogent filed three bezuclastinib NDAs in 2026 for SM and GIST.
  • The pipeline spans KIT, KRAS, and ERBB2 with 800+ treated patients.

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Funding

Total Funding

$2.1B

Above

Industry Average

Funded Over

13 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison Coming Soon

Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Disability Insurance
  • 401(k) Company Match
  • Parental Leave
  • Family Planning Benefits
  • Fertility Treatment Support
  • Tuition Reimbursement
  • Wellness Program

Stock Price

Company News

Yahoo Finance
Nov 6th, 2026
Cogent Biosciences posts $111M quarterly loss as FDA decisions near, trading at 11x book

Cogent Biosciences reported a third-quarter net loss of $111.43 million as it nears several US Food and Drug Administration (FDA) decisions on its drug bezuclastinib. The stock has fallen about 30% over 90 days, though it is up roughly 100% over one year. It last closed at $29.58. The company trades at 11 times book value, against 1.7 times for US biotech peers. It is unprofitable and earns less than $1 million in revenue. A discounted cash flow model puts fair value at $268.29 per share. Analysts' target price is more than 20% above the last trade. Risks include its Phase 3 and early stage programmes, and an adverse FDA ruling could hit the valuation.

Daily Political
Nov 2nd, 2026
Cogent Biosciences, Inc. (COGT) - what are analysts thinking about this stock?

Cogent Biosciences, Inc. (COGT) - what are analysts thinking about this stock? Shares of Cogent Biosciences, Inc. (NASDAQ:COGT - Get Free Report) have been assigned a consensus recommendation of "Moderate Buy" from the twelve analysts that are presently covering the stock, MarketBeat reports. One investment analyst has rated the stock with a sell rating, two have issued a hold rating, eight have assigned a buy rating and one has assigned a strong buy rating to the company. The average 12-month price objective among analysts that have issued ratings on the stock in the last year is $51.56. A number of research firms have commented on COGT. Wall Street Zen lowered shares of Cogent Biosciences from a "hold" rating to a "sell" rating in a research report on Saturday, September 5th. Weiss Ratings reaffirmed a "sell (d-)" rating on shares of Cogent Biosciences in a research note on Friday, October 2nd. Piper Sandler raised their price objective on shares of Cogent Biosciences from $52.00 to $55.00 and gave the stock an "overweight" rating in a report on Monday, August 17th. Wedbush reiterated an "outperform" rating and issued a $55.00 target price on shares of Cogent Biosciences in a research note on Wednesday, September 16th. Finally, HC Wainwright reissued a "buy" rating and issued a $55.00 target price on shares of Cogent Biosciences in a report on Tuesday, September 15th. Cogent Biosciences price performance. Shares of NASDAQ COGT opened at $31.02 on Monday. Cogent Biosciences has a 52-week low of $13.78 and a 52-week high of $43.73. The company has a debt-to-equity ratio of 0.48, a quick ratio of 13.57 and a current ratio of 13.57. The business has a fifty day moving average of $32.43 and a two-hundred day moving average of $35.70. The stock has a market cap of $5.38 billion, a PE ratio of -14.36 and a beta of 0.31. Cogent Biosciences (NASDAQ:COGT - Get Free Report) last posted its earnings results on Monday, August 10th. The technology company reported ($0.52) earnings per share for the quarter, topping the consensus estimate of ($0.55) by $0.03. As a group, equities research analysts expect that Cogent Biosciences will post -2.23 earnings per share for the current fiscal year. Hedge funds weigh in on Cogent Biosciences. Institutional investors have recently bought and sold shares of the business. J.Safra Asset Management Corp acquired a new position in Cogent Biosciences in the second quarter worth $27,000. Integrated Wealth Concepts LLC acquired a new stake in shares of Cogent Biosciences in the second quarter valued at $29,000. Parallel Advisors LLC acquired a new stake in shares of Cogent Biosciences in the first quarter valued at $39,000. Summit Securities Group LLC acquired a new stake in shares of Cogent Biosciences in the first quarter valued at $46,000. Finally, Quantbot Technologies LP bought a new position in shares of Cogent Biosciences in the second quarter valued at about $53,000. About Cogent Biosciences. Cogent Biosciences, Inc is a clinical-stage biotechnology company focused on developing precision medicines for genetically defined diseases. The company uses molecular biology and drug-discovery technologies to design therapies intended to target disease-driving mutations while limiting activity in healthy tissues. Cogent's lead product candidate is bezuclastinib, also known as CGT9486, an investigational, highly selective inhibitor of the KIT D816V mutation. The company is developing bezuclastinib for systemic mastocytosis, a rare disorder involving the abnormal accumulation of mast cells, including both indolent and advanced forms of the disease. Cogent conducts its research and clinical-development activities primarily in the United States and works with clinical centers and research partners in support of its development programs. Receive News & Ratings for Cogent Biosciences Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Cogent Biosciences and related companies with MarketBeat.com's FREE daily email newsletter.

MarketBeat
Aug 14th, 2026
Bank of America Corp DE has $40.18 million stock Holdings in Cogent Biosciences, Inc. $COGT.

Bank of America Corp DE has $40.18 million stock Holdings in Cogent Biosciences, Inc. $COGT. August 14, 2026 Key points. * Bank of America reduced its Cogent Biosciences stake by 12.6% in the first quarter, selling 150,125 shares and retaining 1,043,805 shares valued at approximately $40.18 million, or 0.61% of the company. * Cogent shares opened at $37.31, down 4.3%, with a market capitalization of $6.47 billion. The company reported a quarterly loss of $0.52 per share, beating analyst expectations of a $0.55 loss. * Analyst sentiment remains generally positive: Cogent has a "Moderate Buy" consensus rating and an average price target of $49.10, despite ratings ranging from "Strong Buy" to "Sell." * MarketBeat previews top five stocks to own in September. Bank of America Corp DE reduced its stake in Cogent Biosciences, Inc. (NASDAQ:COGT - Free Report) by 12.6% in the 1st quarter, according to the company in its most recent disclosure with the Securities and Exchange Commission. The firm owned 1,043,805 shares of the technology company's stock after selling 150,125 shares during the period. Bank of America Corp DE owned approximately 0.61% of Cogent Biosciences worth $40,176,000 as of its most recent filing with the Securities and Exchange Commission. Several other hedge funds have also recently bought and sold shares of the company. EverSource Wealth Advisors LLC grew its position in Cogent Biosciences by 1,164.3% in the fourth quarter. EverSource Wealth Advisors LLC now owns 708 shares of the technology company's stock valued at $25,000 after acquiring an additional 652 shares during the last quarter. Osaic Holdings Inc. increased its position in shares of Cogent Biosciences by 41.4% during the second quarter. Osaic Holdings Inc. now owns 4,550 shares of the technology company's stock worth $33,000 after buying an additional 1,333 shares during the period. Strs Ohio acquired a new stake in Cogent Biosciences during the 1st quarter worth about $36,000. Global Retirement Partners LLC bought a new stake in Cogent Biosciences in the fourth quarter worth approximately $37,000. Finally, Parallel Advisors LLC acquired a new position in shares of Cogent Biosciences during the 1st quarter valued at $39,000. Cogent Biosciences stock down 4.3%. COGT stock opened at $37.31 on Friday. The company has a quick ratio of 15.14, a current ratio of 15.14 and a debt-to-equity ratio of 0.41. The firm has a market capitalization of $6.47 billion, a PE ratio of -17.27 and a beta of 0.38. Cogent Biosciences, Inc. has a twelve month low of $11.41 and a twelve month high of $43.73. The stock has a 50-day simple moving average of $37.87 and a two-hundred day simple moving average of $36.65. Cogent Biosciences (NASDAQ:COGT - Get Free Report) last announced its quarterly earnings results on Monday, August 10th. The technology company reported ($0.52) earnings per share (EPS) for the quarter, topping analysts' consensus estimates of ($0.55) by $0.03. On average, equities analysts predict that Cogent Biosciences, Inc. will post -2.2 EPS for the current fiscal year. Analyst ratings changes. A number of equities research analysts recently weighed in on the stock. Wedbush restated an "outperform" rating and issued a $55.00 target price on shares of Cogent Biosciences in a report on Friday, May 29th. Weiss Ratings reissued a "sell (d-)" rating on shares of Cogent Biosciences in a report on Wednesday, July 8th. HC Wainwright increased their price objective on Cogent Biosciences to $55.00 and gave the stock a "buy" rating in a research note on Wednesday, May 6th. Finally, Guggenheim raised their target price on Cogent Biosciences from $45.00 to $52.00 and gave the company a "buy" rating in a report on Wednesday. Two research analysts have rated the stock with a Strong Buy rating, eight have given a Buy rating, two have given a Hold rating and one has given a Sell rating to the stock. Based on data from MarketBeat.com, the company presently has an average rating of "Moderate Buy" and an average price target of $49.10. Discover more Stock ratings screener ETF screener access Cogent Biosciences company profile. Cogent Biosciences is a clinical-stage biopharmaceutical company focused on the discovery and development of small-molecule therapies that modulate the tumor microenvironment. The company's research centers on targeting colony-stimulating factor 1 receptor (CSF1R), a key regulator of tumor-associated macrophages that can promote tumor growth and immune evasion. By selectively inhibiting CSF1R, Cogent Biosciences aims to restore immune surveillance and enhance the efficacy of existing cancer treatments. The company's lead asset is an orally bioavailable CSF1R inhibitor that has advanced into early-stage clinical trials for various solid tumors. Want to see what other hedge funds are holding COGT? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Cogent Biosciences, Inc. (NASDAQ:COGT - Free Report). This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Cogent Biosciences, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Cogent Biosciences wasn't on the list. While Cogent Biosciences currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys. 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Yahoo Finance
May 30th, 2026
Cogent's bezuclastinib combination doubles median PFS to 16.5 months in GIST trial, FDA priority review granted

Cogent Biosciences presented detailed Phase 3 PEAK trial data at the 2026 ASCO annual meeting, showing bezuclastinib combined with sunitinib achieved median progression-free survival of 16.5 months versus 9.2 months for sunitinib alone in gastrointestinal stromal tumour patients (HR=0.50, p<0.0001). This marks the first treatment to demonstrate statistically significant advantage against an active comparator in GIST patients. The combination showed clear benefit across all mutational subgroups, with mean treatment duration of 21.4 months. The safety profile was consistent with sunitinib alone, with no unique risks observed. The FDA granted Priority Review for the bezuclastinib combination in GIST patients previously treated with imatinib, with a PDUFA date of 30 November 2026. Cogent has initiated a new trial in first-line GIST patients.

Yahoo Finance
May 7th, 2026
Cogent Biosciences Q1 loss widens to $97M as bezuclastinib regulatory push lifts P/B to 11.3x

Cogent Biosciences reported a wider Q1 2026 net loss of $97.35 million as the biotech company increased spending on regulatory and launch preparation for bezuclastinib. The loss follows a remarkable one-year shareholder return of approximately seven times, though year-to-date returns have moderated to 3.25%. The company trades at a price-to-book ratio of 11.3 times, substantially above the US biotechs industry average of 2.3 times, reflecting investor optimism about bezuclastinib's potential. However, Cogent remains pre-revenue with net losses of $354.3 million, making its valuation heavily dependent on analyst forecasts of rapid revenue growth and profitability within three years. Shares recently declined 3% to $35.87, suggesting investor caution around elevated spending against the backdrop of future execution risks.

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