SpliSense, a biotechnology firm specialising in RNA-based therapies for pulmonary diseases, has secured up to $13 million in funding from the Cystic Fibrosis Foundation to advance Phase 2b clinical trials of its investigational drug SPL84 for cystic fibrosis treatment. The funding follows successful Phase 2a results showing a 10 percentage point improvement in lung function in nearly 70% of patients compared to placebo, marking the first clinical proof-of-concept for an inhaled antisense oligonucleotide therapy in a respiratory condition. The Phase 2b study will evaluate SPL84's safety and efficacy in approximately 40 patients with the 3849+10kb C→T mutation across sites in the United States, Europe and Israel, with topline results expected in the second half of 2025.

American Airlines leads fundraising at Celebrity Ski to support Cystic Fibrosis research. Table of Contents The Celebrity Ski weekend in Beaver Creek, Colorado, brought together airline staff, corporate partners and community supporters for a concentrated burst of fundraising and awareness. Over the course of the retreat-style event, participants helped raise more than $1.6 million to benefit the Cystic Fibrosis Foundation. Organizers emphasized both the social and scientific impact of the effort, noting that the proceeds will support ongoing clinical research and patient care initiatives focused on improving outcomes for people living with cystic fibrosis, a genetic disorder that primarily affects the lungs and digestive system. More than 425 attendees and volunteers joined the weekend of events, which featured familiar faces from sports and entertainment alongside airline employees. Notable participants included Carli Lloyd, Alexi Lalas and Mark Ingram, and a live performance curated by Warner Records spotlighted artist Michael Marcagi. In addition to on-slope activities and concerts, supporters contributed through silent auctions, sponsorship packages and mile-based donations, continuing traditions that have made the event a cornerstone of corporate philanthropy tied to the fight against CF. Pubblicità Event highlights and community impact. The weekend combined recreational programming with intentional fundraising, bringing attention to both the work of clinicians and the lived experience of people with CF. Attendees took part in a variety of activities meant to strengthen community ties and fundraise, while the event itself amplified the Foundation's research priorities. Organizers noted that the energy generated by volunteers and celebrity guests translated directly into financial support for trials, therapies and care centers. The tally of more than $1.6 million will be directed into the Foundation's research portfolio, bolstering efforts to develop new treatments and move closer to a cure. Notable participants and programming. High-profile guests helped elevate the weekend's visibility, attracting additional donors and media attention. The mix of professional athletes, entertainers and airline personnel created a broad base of engagement that extended beyond the slopes. Programming included participant-driven fundraisers, performances and networking sessions that highlighted how corporate resources can amplify nonprofit missions. The presence of celebrity backers served as a catalyst to drive both donations and public awareness for the Cystic Fibrosis Foundation. How donations were collected. Fundraising methods combined traditional giving with creative corporate mechanisms. In addition to auction and sponsorship revenue, American Airlines leveraged its loyalty ecosystem by contributing hundreds of millions of AAdvantage miles over time to support similar fundraising efforts nationwide. This event also used direct financial gifts and in-kind support to cover logistical costs, maximizing the amount available for research and patient care. Such blended approaches have helped sustain the Celebrity Ski event over four decades. Pubblicità Longstanding partnerships and leadership. American's involvement in the Celebrity Ski program is part of a much larger philanthropic relationship with the CF community. The airline has contributed to more than $50 million in support of the Foundation across multiple initiatives, underscoring a long-term commitment to advancing treatments and care. Company leaders described the weekend as an example of team members and partners working together to make a measurable difference outside of the day-to-day travel business. Foundation leadership characterized American as a vital, long-running corporate supporter whose backing has directly supported scientific breakthroughs. About the organizations. American Airlines operates a global network and is powered by a large workforce of aviation professionals who emphasize customer service and community engagement. The airline flies thousands of daily flights to hundreds of destinations worldwide and serves millions of customers annually. As a company, American highlights milestones in innovation and continues to invest in both customer experience and charitable activities; it also marks its centennial year in 2026. The airline is a founding member of the oneworld alliance, whose members serve more than 900 destinations around the globe. The Cystic Fibrosis Foundation leads global efforts to accelerate research into treatments and ultimately a cure. Based in Bethesda, Md., the Foundation funds more CF research than any other organization and supports a national network of accredited care centers recognized by the National Institutes of Health as a model for chronic disease care. Much of the progress in current CF therapies has been made possible because of Foundation-funded science. The organization operates as a donor-supported nonprofit; more information is available at cff.org.

American Airlines brings together celebrities and communities in Colorado to support Cystic Fibrosis research. (NEWS) FORT WORTH, TX, United States, 2026-Mar-24 - /Travel PR News/ - A long-running partnership between American Airlines and the Cystic Fibrosis Foundation took center stage once again in Colorado, as the airline and its partners gathered for the 41st Celebrity Ski event in Beaver Creek - a fundraising initiative that blends community engagement with efforts to advance medical research. The annual event brought together airline employees, industry partners and high-profile guests for a weekend of activities on the slopes, all aimed at supporting research into cystic fibrosis, a genetic condition that affects the lungs and other organs. According to details shared in official updates, the initiative is part of a broader commitment by American Airlines to support healthcare causes beyond its core travel operations. A decades-long fundraising effort Over the years, the airline has contributed more than $50 million toward cystic fibrosis research and care, making it one of the foundation's longest-standing corporate supporters. The Celebrity Ski event has become a cornerstone of that relationship, serving as both a fundraising platform and a way to raise awareness about the disease. This year's gathering welcomed more than 400 participants and volunteers, alongside a number of sports and entertainment figures, including Carli Lloyd, Alexi Lalas, and Mark Ingram. Attendees also took part in live entertainment events, adding a social and cultural dimension to the weekend. Supporting research and patient care The Cystic Fibrosis Foundation remains a leading force in funding research into treatments and potential cures, with many existing therapies linked to its support. According to the organisation, advances in treatment have helped improve life expectancy for people living with the condition, reflecting decades of sustained investment in research and care. American Airlines' involvement extends beyond the ski event itself. The airline has also supported fundraising initiatives through the donation of AAdvantage loyalty miles and broader corporate contributions, helping to expand the reach of the foundation's work. Travel industry engagement beyond transportation The continued partnership highlights a wider trend in the aviation sector, where airlines are increasingly aligning with social and healthcare initiatives as part of their broader corporate responsibility strategies. By leveraging their networks, customer base and brand visibility, carriers are playing a role in supporting causes that extend beyond travel. As the airline approaches its centennial year in 2026, initiatives such as the Celebrity Ski event illustrate how long-term partnerships can contribute to both community engagement and global health efforts - demonstrating the evolving role of airlines in supporting causes that resonate with their passengers and employees alike.