Big Picture Bio launches with £1.5 million to design cancer combination therapies. London-based Big Picture Bio Ltd has been founded to identify, design and optimise cancer combination therapies. It uses a generative world model of how tumours, immune cells and surrounding tissue interact across disease sites and patient subgroups. The company, which announced its launch on 17 September 2026, pairs AI-driven modelling with targeted wet lab validation. It aims to tackle one of the hardest problems in oncology drug discovery: finding combinations with a greater likelihood of working in patients. Funding to move from in silico design to the bench. Big Picture Bio has closed a £1.5 million pre-seed round, co-led by Kadmos Capital and Exceptional Ventures. Gloucester Ventures and angel investor John White also took part. The round sits alongside £700,000 of non-dilutive funding from Innovate UK through its Investor Partnerships Programme, giving a combined £2.2 million. The company will use the funds to take its first designed drug combinations from in silico design into wet lab validation. The initial focus is cancer and immune-mediated diseases. The platform seeks optimal combinations of drugs, and their sequencing, to minimise residual disease. Testing predictions against clinical outcomes. The company says its platform has been validated against real-world clinical outcomes presented at ASCO. It also reports that the platform correctly predicted the failure of Regeneron's recent fianlimab trial. Big Picture Bio does not position clinical prediction as its end product. It uses this validation to test whether its models are identifying combinations with potential for clinical impact. The model reasons from the ground up, so its predictions are fully explainable and can be traced back to the underlying biology. Dr Kerstin Papenfuss, chief executive officer and co-founder, noted that more than 900 billion combinations are possible, too many for any laboratory to test exhaustively. "Cancer is not one disease driven by one target, but we still develop drugs as if it were," she said. Her aim is to "model the disease as the dynamic system it actually is, then design against it". She added: "This funding takes our first designed combinations out of the model and into the lab." Founders and advisers. Papenfuss was previously Director of Pharma at Deep Science Ventures (DSV), where she founded 12 therapeutics and enabling-technology companies. Dr Mark Hammond, chief technology officer and co-founder, co-founded DSV and led its engineering work in agentic scientific discovery. The advisory team spans oncology, target validation, drug discovery, translational biology and commercial strategy. It includes Dr Laura Rosenberg, Director of Target Validation at AstraZeneca, and Dr Duncan Young, Head of Search & Evaluation, Oncology Business Development & Licensing at AstraZeneca. Dr Garry Pairaudeau, chief executive officer and co-founder of DaltonTx and former chief technology officer of Exscientia, and Dr Christian Dillon, chief scientific officer at PhoreMost, also advise the company. Dom Falcao, founder of Deep Science Ventures, commented that the founders had steered DSV through the creation of companies including Neobe, Cureage and Kindling, and that "almost every company they have built is on track to make it into the clinic". Remy Kesrouani, Managing Partner at Kadmos Capital, said the company was "applying a genuinely differentiated approach to AI to one of drug development's hardest problems". Paolo Pio, co-founder and General Partner at Exceptional Ventures, noted that the problem lies in "how to identify the right combination therapies faster and with greater confidence". Dom Falcao, Founder of Deep Science Ventures Paolo Pio, Co-founder and General Partner, Exceptional Ventures Remy Kesrouani, Managing Partner, Kadmos Capital Dr Kerstin Papenfuss, CEO and co-founder, Big Picture Bio

Big Picture Bio founded to identify, design and optimize promising cancer combination therapies. Big Picture Bio Ltd., has been founded to identify, design and optimize promising cancer combination therapies, using a generative world model to understand how tumors, immune cells and surrounding tissue interact across disease sites and patient subgroups. By combining AI-driven modelling with targeted wet lab validation, the Company aims to address one of oncology's most challenging drug discovery problems - identifying combinations with a greater likelihood of working in patients. The Company has closed a £1.5 million (~$2 million USD) pre-seed funding round, co-led by Kadmos Capital and Exceptional Ventures with participation from Gloucester Ventures and angel investor John White. The pre-seed funding is in addition to £700,000 (~$950,000 USD) in non-dilutive funding received from Innovate UK through its Investor Partnerships Programme. Together, the funding provides £2.2 million (~$3 million USD) to support Big Picture Bio as the Company takes its first designed drug combinations from in silico design into wet lab validation. A key test of Big Picture Bio's combination-design approach is whether it can predict how treatments will perform in patients. The Company's platform has been validated against real-world clinical outcomes presented at ASCO, as well as correctly predicting the failure of Regeneron\'s recent fianlimab trial. Rather than positioning clinical prediction as the end product, Big Picture Bio uses this validation to test whether its models are identifying combinations with potential for clinical impact. The model reasons from the ground up, so its predictions are fully explainable and can be traced back to the underlying biology. Big Picture Bio was founded by Dr Kerstin Papenfuss, CEO and co-founder, and Dr Mark Hammond, CTO and co-founder, bringing extensive experience across drug discovery, venture creation and AI-enabled scientific discovery. Kerstin previously served as Director of Pharma at Deep Science Ventures (DSV), where she founded 12 therapeutics and enabling-technology companies, while Mark co-founded DSV and led its engineering work in agentic scientific discovery. Together, they bring expertise spanning translational science, therapeutics and AI to Big Picture Bio's mission of designing cancer combination therapies. The Company is supported by an advisory team with expertise in oncology, target validation, drug discovery, translational biology and commercial strategy. This includes Dr Laura Rosenberg, Director of Target Validation at AstraZeneca; Dr Duncan Young, Head of Search & Evaluation, Oncology Business Development & Licensing at AstraZeneca; Dr Garry Pairaudeau, CEO and co-founder of DaltonTx and former CTO of Exscientia; and Dr Christian Dillon, Chief Scientific Officer at PhoreMost. Cancer is not one disease driven by one target, but News Medical still develop drugs as if it were. Combinations are how News Medical beat it - and with more than 900 billion of them possible, no lab on earth can test its way to the right ones. That is the problem News Medical built Big Picture Bio to solve: model the disease as the dynamic system it actually is, then design against it - combinations chosen because they are most likely to work in patients, not because they were the ones News Medical could get to. This funding takes its first designed combinations out of the model and into the lab." Dr. Kerstin Papenfuss, CEO and Co-Founder, Big Picture Bio Dom Falcao, Founder of Deep Science Ventures added: "For a decade, Mark and Kerstin have steered DSV through the creation of a slew of extremely exciting companies solving precisely these kinds of complex diseases, including Neobe, Cureage and Kindling, and almost every company they have built is on track to make it into the clinic. Instilling that experience and expertise into a model that moves beyond the bleeding edge in AI to solve complex diseases at scale is a natural evolution of the methodology for building advanced therapeutics companies at DSV. It\'s been the greatest privilege of my career to build DSV alongside Mark and Kerstin and I am so glad DSV can be a part of the next phase of their journey." Remy Kesrouani, Managing Partner, Kadmos Capital, said: "I had the privilege of working closely with Kerstin and Mark at the very beginning of Deep Science Ventures, and saw first-hand the determination, conviction and sheer resolve they bring to building ambitious, scalable businesses. Big Picture Bio is the culmination of that journey, applying a genuinely differentiated approach to AI to one of drug development's hardest problems: predicting how complex clinical trials will actually behave." Paolo Pio, Co-Founder and General Partner, Exceptional Ventures, commented: "Big Picture Bio is going after a problem at the heart of modern oncology - how to identify the right combination therapies faster and with greater confidence. We believe the team has the scientific depth, technical ambition and commercial focus to build something genuinely important - a platform that can deliver value to partners today while laying the foundation for the next generation of cancer therapies. We are proud to co-lead the round along with Kadmos and support the company's next stage of growth." Be the first to rate this article