Deep Genomics

Deep Genomics

AI-driven RNA-based drug discovery platform

Overview

Deep Genomics uses AI to speed up drug discovery by studying RNA biology and how genetic variants affect gene expression. Its main product, the AI Workbench, analyzes genomic data to identify novel drug targets and potential therapies for genetic diseases. It differentiates itself by focusing on RNA-level mechanisms and expanding its target discovery capabilities across versions. The goal is to provide a license-ready platform that yields actionable targets for collaboration or internal development, accelerating therapies for patients with genetic conditions.

About Deep Genomics

Simplify's Rating
Why Deep Genomics is rated
C+
Rated B on Competitive Edge
Rated C on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

AI & Machine Learning

Biotechnology

Healthcare

Company Size

51-200

Company Stage

Series C

Total Funding

$236.8M

Headquarters

Toronto, Canada

Founded

2014

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Simplify's Take

What believers are saying

  • Thong Q. Le became board chair on July 23, 2026, strengthening fundraising.
  • Deep Genomics posted active Cambridge hiring in May 2026, showing operating momentum.
  • BioMarin still validates Deep Genomics' partnering model across four rare-disease programs.

What critics are saying

  • Deep Genomics has not disclosed a new financing round since July 2021.
  • No public human efficacy data followed the 2023 clinic goal.
  • If first-in-human data miss by 2027, BigRNA becomes an expensive research demo.

What makes Deep Genomics unique

  • BigRNA uses 1.8 billion parameters trained on one trillion genomic signals.
  • DeepADAR and REPRESS extend the platform beyond splicing into RNA editing.
  • Toronto and Cambridge teams combine AI, genomics, and oligonucleotide biology.

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Funding

Total Funding

$236.8M

Above

Industry Average

Funded Over

4 Rounds

Notable Investors:
Series C funding is usually for startups that are doing well and are looking for more money to fuel major growth, such as acquiring other companies, expanding into global markets, or launching new product lines. Investors typically include larger venture capital firms and private equity.
Series C Funding Comparison
Above Average

Industry standards

$50M
$50M
Medium
$62M
SeatGeek
$100M
Oura
$180M
Deep Genomics

Benefits

Company Equity

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Professional Development Budget

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

1%

2 year growth

-2%
Deep Genomics
Aug 1st, 2026
Deep Genomics CEO Brian O'Callaghan honored as gold stevie(r) Award winner in 2025 Stevie Awards for Technology Excellence.

Deep Genomics CEO Brian O'Callaghan honored as gold stevie(r) Award winner in 2025 Stevie Awards for Technology Excellence. August 1, 2026 TORONTO, August 1, 2025 - Brian O'Callaghan, CEO of Deep Genomics, the AI-first TechBio organization pioneering a new path for genomic R&D, has been named Biotech Executive of the Year, winning gold in the second annual Stevie Awards for Technology Excellence. Since his appointment as CEO in September 2023, O'Callaghan has led Deep Genomics into a new era of innovation and growth, helping to transition the company from a single-model initiative to a fully integrated platform of AI foundation models for drug discovery. Deep Genomics has been a pioneer in the drug discovery space through its cohesive AI foundation model platform, which dramatically accelerates therapeutic discovery. The company's flagship AI foundation model, BigRNA, is reshaping the landscape of RNA research and development with 1.8 billion tunable parameters trained on over one trillion genomic signals. Under O'Callaghan's leadership, Deep Genomics launched additional proprietary AI foundation models that work alongside BigRNA, including DeepADAR for RNA editing and REPRESS, which accurately predicts microRNA (miRNA) binding and mRNA degradation directly from RNA sequences. O'Callaghan has also driven the strategic and structural expansion of Deep Genomics, opening a new lab and office in Cambridge, Massachusetts, expanding its Toronto headquarters, and appointing key leaders across science and business functions. "Winning a Stevie Award is a reflection of the extraordinary talent and mission-driven mindset at Deep Genomics," said O'Callaghan. "Our AI foundation model platform is unlocking AI-driven drug discovery in a way that was previously inconceivable, and I'm incredibly proud of our team for driving innovations that bring us closer to transforming care for patients." "We're proud to honor the 2025 Stevie Awards for Technology Excellence winners for their remarkable achievements," said Stevie Awards President Maggie Miller. "We look forward to celebrating their innovation and impact at the awards ceremony on September 16." The Stevie Awards for Technology Excellence recognize the remarkable achievements of individuals, teams, and organizations that are shaping the future of technology across all industry sectors. Winners of the awards, named the Stevies from the Greek word meaning "crowned," will be recognized during a gala awards event on Tuesday, September 16, at the Marriott Marquis Hotel in New York City. More than 160 professionals worldwide participated in the judging process to select this year's honorees. Details about the Stevie Awards for Technology Excellence and the list of 2025 Stevie winners are available at www.StevieAwards.com/Tech. About Deep Genomics Deep Genomics is an AI-first TechBio organization pioneering a new path for genomic R&D through its multidisciplinary team of AI and biology scientists and its Foundation Model Platform. Leveraging cutting-edge AI technologies and biological insights, Deep Genomics is at the forefront of revolutionizing drug discovery and development. Through its innovative approach and collaborative partnerships, Deep Genomics aims to accelerate the delivery of life-saving therapeutics to patients worldwide. Deep Genomics is located in Toronto, Ontario, and Cambridge, Massachusetts. For more information, visit www.deepgenomics.com and follow Deep Genomics on LinkedIn. About the Stevie Awards Stevie Awards are conferred in nine programs: the Asia-Pacific Stevie Awards, the German Stevie Awards, the Middle East & North Africa Stevie Awards, The American Business Awards(R), The International Business Awards(R), the Stevie Awards for Great Employers, the Stevie Awards for Women in Business, the Stevie Awards for Technology Excellence and the Stevie Awards for Sales & Customer Service. Stevie Awards competitions receive more than 12,000 entries each year from organizations in more than 70 nations and territories. Honoring organizations of all types and sizes and the people behind them, the Stevies recognize outstanding performance in the workplace worldwide. Learn more about the Stevie Awards at http://www.StevieAwards.com. Media Contact: [email protected]

Deep Genomics
Jul 23rd, 2026
Deep Genomics appoints Thong Q. Le as Chair of the Board of Directors.

Deep Genomics appoints Thong Q. Le as Chair of the Board of Directors. July 23, 2026 CAMBRIDGE, Mass. & TORONTO - Deep Genomics, the AI-first TechBio organization pioneering a new path for genomic medicines with its AI foundation model platform, today announced the appointment of Thong Q. Le as chair of its Board of Directors. "Since joining our Board in 2025, Thong has been a trusted advisor and a strong advocate for our vision," said Brendan Frey, Founder and Chief Innovation Officer of Deep Genomics. "He brings a fresh energy and deep experience supporting the life sciences industry to the role, making him exceptionally well positioned to lead our Board as Deep Genomics continues to advance AI-driven drug discovery." Mr. Le joined the Deep Genomics Board of Directors in 2025, bringing more than 20 years of experience investing in the life sciences sector. Throughout his career, he has guided high-impact investments and supported deal-making efforts that have driven meaningful health outcomes. He also serves as investment director and managing partner of the Strategic Investment Fund (SIF) for the Gates Foundation, and chairman of Accelerator Life Science Partners (ALSP), a venture capital firm dedicated to building next-generation life science companies. As Chair, Mr. Le will help guide Deep Genomics through its next phase of growth as the company advances its internal pipeline toward clinical development, expands strategic collaborations, and further establishes its leadership at the intersection of AI, genomics, and drug discovery. "I'm honored to take on the role of Chair of the Board of Directors at such an exciting time for Deep Genomics and the broader TechBio industry," said Le. "Deep Genomics has built a unique platform and world-class team leading at the intersection of AI and biology. I look forward to continuing my work alongside the company as it advances its mission to transform how medicines are discovered and developed." Mr. Le succeeds Chip Baird, who served as Chair of the Board for the past three years. Mr. Baird will continue to support Deep Genomics as a non-executive director and will serve as Chair of the Audit Committee. To learn more about Deep Genomics' work and its groundbreaking impact in the realm of genomic R&D, visit www.deepgenomics.com. For those interested in joining this team of TechBio innovators, visit https://www.deepgenomics.com/careers/. About Deep Genomics Deep Genomics is a fully integrated AI-first TechBio company pioneering a new approach to drug discovery with its Biological Foundation Model (BioFM) platform. At the intersection of genomics, drug development, and AI, Deep Genomics brings together a world-class team of scientists, engineers, and researchers to solve complex biological challenges at scale and accelerate the discovery and development of genetic medicines to improve patient outcomes. Deep Genomics is located in Toronto, Ontario, and Cambridge, Massachusetts. For more information, visit www.deepgenomics.com and follow Deep Genomics Inc. on LinkedIn and Twitter.

Deep Genomics
Oct 6th, 2025
Thong Q. Le and Paul Sekhri Join Board of Directors at Deep Genomics

Thong Q. Le and Paul Sekhri join Board of Directors at Deep Genomics. Pictured: Thong Q. Le (left) and Paul Sekhri (right), the newest members of the Board of Directors for Deep Genomics Cambridge, Mass. / Toronto, CA - October 6, 2025 - Deep Genomics, the AI-first TechBio organization pioneering a new path for genomic medicines with its AI foundation model platform, today announced the appointment of respected business leaders Thong Q. Le and Paul Sekhri to its Board of Directors. "We feel incredibly lucky to have the talents of Thong and Paul join our Board of Directors", said Brian O'Callaghan, Chief Executive Officer of Deep Genomics. "Their collective decades of experience shaping the life sciences and biotechnology industry will be invaluable as we continue towards our mission of delivering AI-powered genetic medicines to patients." Thong Q. Le brings more than two decades of investment experience in the life sciences industry, with a strong track record of making impactful investments that improve lives, shaping effective investment strategies and aiding deal-making processes. Mr. Le currently serves as investment director and managing partner of the Strategic Investment Fund (SIF) for the Gates Foundation. Mr. Le also serves as chairman of Accelerator Life Science Partners (ALSP), a venture capital firm focused on developing next-generation life science companies. He has served as a director, founding president and CEO of more than a dozen ALSP portfolio companies, including Petra Pharma, Rodeo Therapeutics and Lodo Therapeutics. Mr. Le currently serves on several private biotech and nonprofit organization boards. "In my time working with this industry, I've seen firsthand how the right combination of science, technology and leadership can transform what's possible in drug discovery," said Mr. Le. "Deep Genomics has all of those ingredients, and I'm thrilled to have this opportunity to help guide its continued growth." Paul Sekhri is the current Chair, President and CEO of vTv Therapeutics Inc., Chair of the Board of Resolution Therapeutics, and Executive Chair of Violet Therapeutics Inc., bringing more than 35 years of experience in business development and strategy across top life sciences, pharmaceutical and biotechnology companies. Most recently, he served as President and CEO of eGenesis Inc. and Lycera Corp. Previously, Mr. Sekhri held senior leadership positions at Sanofi, Teva Pharmaceuticals, TPG Biotech, Cerimon Pharmaceuticals Inc., Ariad Pharmaceuticals and Novartis. He currently serves on the Board of Veeva Systems, AdhereTech Inc., Kayothera; is Chair of Young Concert Artists (YCA), and sits on the Advisory Council of the New York Philharmonic. Mr. Sekhri commented, "I am excited to be joining the Deep Genomics Board at such a pivotal time in therapeutics, and I remain inspired by their ability to advance a new generation of medicines with the power of AI. I look forward to contributing to such important TechBio advancements alongside this talented team." To learn more about Deep Genomics' work and its groundbreaking impact in the realm of genomic R&D, visit www.deepgenomics.com. For those interested in joining this team of TechBio innovators, visit https://www.deepgenomics.com/careers/. About Deep Genomics Deep Genomics is a multidisciplinary team of AI and biology scientists dedicated to pioneering a new era of genomic research and development through its AI foundation models platform. Leveraging cutting-edge AI technologies and biological insights, Deep Genomics is revolutionizing drug discovery and development. Through its innovative approach and collaborative partnerships, Deep Genomics aims to accelerate the delivery of life-changing genetic medicines to patients worldwide. Deep Genomics is located in Toronto, Ontario, and Cambridge, Massachusetts. For more information, visit www.deepgenomics.com and follow Deep Genomics Inc. on LinkedIn and Twitter.

Deep Genomics
Aug 1st, 2025
Deep Genomics CEO Brian O'Callaghan honored as Gold Stevie(R) Award winner in 2025 Stevie Awards for Technology Excellence

Under O'Callaghan's leadership, Deep Genomics launched additional proprietary AI foundation models that work alongside BigRNA, including DeepADAR for RNA editing and REPRESS, which accurately predicts microRNA (miRNA) binding and mRNA degradation directly from RNA sequences.

Medium
Jun 10th, 2025
Deep Genomics secures $180M for AI drug discovery

Deep Genomics, a Canadian biotech company, closed a $180 million Series C funding round led by Softbank, with investments from CPPIB, Fidelity, and others. The company, supported by Amplitude Ventures, uses AI to revolutionize drug discovery, focusing on RNA therapeutics. The funding will expand their AI workbench and pipeline, aiming to advance four programs into the clinic by 2023.

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