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eGenesis

Genetically engineered porcine kidneys for humans

Overview

eGenesis develops genetically engineered porcine (pig) kidneys and other organs that are compatible with human bodies, aiming to address the organ shortage by enabling transplantations into humans. Its product is created by editing pig genes to reduce rejection and improve compatibility, producing HuCo™ (Human Compatible) organs and cells that can be transplanted by healthcare providers. Unlike many biotech firms that focus on synthetic tissues or other approaches, eGenesis concentrates on xenotransplantation—using animal organs engineered to be accepted by the human immune system—for use in patients awaiting transplants. The company’s goal is to save lives and improve quality of life by expanding the supply of transplantable organs and reducing wait times for patients in need.

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About eGenesis

Simplify's Rating
Why eGenesis is rated
B
Rated A on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

51-200

Company Stage

N/A

Total Funding

$472.7M

Headquarters

Cambridge, MA

Founded

2015

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What believers are saying

  • September 2026 data showed three patients kept kidney function more than eight months without dialysis.
  • FDA cleared RESTORE for 33 waitlisted patients, with first enrollment expected in first quarter 2027.
  • June and October 2026 hires added CFO, CCO, and manufacturing leadership for commercialization readiness.

What critics are saying

  • EGEN-2784 remains unapproved; a safety setback in the 2027 RESTORE trial could crater confidence.
  • eGenesis has no revenue and depends on financing, including Natco's $24.7 million note by October 2026.
  • Pig-organ manufacturing and supply scaling remains unproven; one contamination failure could halt the company.

What makes eGenesis unique

  • EGEN-2784 is the first FDA-cleared, Phase 1/2/3 porcine kidney transplant program.
  • eGenesis achieved five human kidney transplants by September 2026, including two bridge-to-human cases.
  • Its multiplex genome-editing platform tackles rejection and pathogen safety better than one-edit competitors.

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Funding

Total Funding

$472.7M

Above

Industry Average

Funded Over

6 Rounds

Convertible funding comparison data is currently unavailable. We're working to provide this information soon!
Convertible Funding Comparison Coming Soon

Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • 401(k) Retirement Plan
  • 401(k) Company Match
  • Paid Vacation
  • Paid Sick Leave
  • Paid Holidays
  • Conference Attendance Budget
  • Professional Development Budget

Growth & Insights and Company News

6 month growth

1%

1 year growth

0%

2 year growth

0%
Contract Pharma
Oct 22nd, 2026
eGenesis picks Daniel Leblanc as new Chief Manufacturing and Supply Officer.

eGenesis picks Daniel Leblanc as new Chief Manufacturing and Supply Officer. The company's lead product is a genetically engineered porcine kidney for human patients with kidney failure. October 22, 2026 Content Marketing Editor Why This Matters: See our coverage of other industry executive team appointments and promotions here. eGenesis, a biotechnology company developing human-compatible engineered organs, appointed Daniel Leblanc Chief Manufacturing and Supply Officer. What eGenesis does. The company, headquartered in Cambridge, Mass., aims to develop these organs to address what it calls a global organ shortage. Currently, eGenesis is advancing its lead product, EGEN-2784, a genetically engineered porcine kidney for patients with kidney failure. Leblanc preceded his eGenesis appointment by serving as Chief Technology Officer at Ensoma. He previously held senior leadership positions at Flexion Therapeutics. The most recent of these was Senior Vice President of Chemistry, Manufacturing, and Controls (CMC) Operations. Earlier in his career, Leblanc held CMC and manufacturing leadership positions at Merck Serono and Alkermes. Overall, he brings more than 25 years of global biopharmaceutical industry experience to his new position and company. Manufacturing and Supply expertise needed. "Dan brings extensive expertise in manufacturing and operational strategy for innovative therapies," eGenesis President and CEO Mike Curtis, PhD, said. "His leadership will be instrumental as we advance our clinical programs and prepare for future commercialization... We [will] continue to build the infrastructure necessary to bring genetically engineered organs to patients in need." "eGenesis is at the forefront of the treatment of organ failure," Leblanc said. "I am excited to join the company at such an important stage in its development. The progress eGenesis has made in advancing genetically engineered organs into the clinic underscores the tremendous potential of this technology. I look forward to working with the team to further strengthen manufacturing capabilities, establish scalable operations, and support [their] mission." To date, the United States FDA has cleared eGenesis to conduct clinical studies across its kidney and liver programs. Add us as a preferred source on Google. Get the latest Contract Pharma news, insights and analysis in your Google Search and AI experiences.

CNBC TV18
Sep 28th, 2026
Natco Pharma raises eGenesis investment to $16.7 million, backs gene-edited organ research.

Natco Pharma raises eGenesis investment to $16.7 million, backs gene-edited organ research. Natco Pharma has raised its investment in US biotech eGenesis to $16.7 million from $14 million, as it backs research aimed at using gene-edited pig organs for human transplants. By Megha Rani September 28, 2026, 4:33:27 PM IST (Updated) Natco Pharma has increased its proposed investment in US-based biotechnology company eGenesis Inc. to $16.7 million from the previously disclosed $14 million, the company said in an exchange filing on Monday, September 28. The investment will be made through Natco Pharma's wholly owned subsidiaries Natco Pharma (Canada) Inc. and Natco Pharma USA LLC through convertible promissory notes carrying an interest rate of 8% compounded annually. Natco Pharma (Canada) will invest $13.7 million, while Natco Pharma USA will invest another $3 million. The investment is expected to be completed by October 31, 2026. The latest investment is an update to Natco Pharma's disclosure on August 25. The company also said there has been a change in the subsidiaries participating in the investment. Following the proposed investment, Natco Pharma's total investment in eGenesis will rise to $24.7 million, including the $8 million it invested in the US biotech in 2024. What does eGenesis do? eGenesis is developing technology that could potentially help address the shortage of human organs available for transplantation. The company uses gene editing to modify pig organs so they can potentially be transplanted into humans while reducing the risk of rejection and viral transmission. eGenesis is currently developing programmes involving kidney transplantation, acute liver failure and heart transplantation. The company made headlines in March 2024 after conducting the world's first pig-kidney transplant in a living patient. The transplant was authorised by the US Food and Drug Administration under its Expanded Access pathway. Two additional patients subsequently received pig-kidney transplants, Natco Pharma said. eGenesis is currently a clinical-stage, pre-revenue company and is conducting clinical trials involving pig-kidney transplantation in humans and pig-liver perfusion. For Natco Pharma, the investment is aimed at backing new-age therapeutic programmes addressing critical unmet medical needs, according to the company's disclosure.

ScanX
Sep 28th, 2026
Natco Pharma raises investment in xenotransplant biotech eGenesis to $24.7M via convertible notes

Natco Pharma has increased its investment in US biotechnology company eGenesis to $24.70 million. The Indian pharmaceutical firm raised its latest commitment to $16.70 million from a previously disclosed $14 million, bringing its total stake to $24.70 million. The investment is structured through convertible promissory notes carrying an 8% annual interest rate. NATCO Pharma (Canada) Inc. will invest $13.70 million, whilst NATCO Pharma USA LLC will contribute $3 million. The acquisition is targeted for completion by 31 October 2026. eGenesis is a clinical-stage company developing transplantable organs through genome engineering to address the global shortage of human donors. In March 2024, the company achieved the world's first porcine kidney transplant in a living patient, authorised by the US FDA. Natco's relationship with eGenesis began in 2024 with an initial $8 million investment.

NPR
Sep 7th, 2026
Genetically modified pig kidneys bridge two patients to human transplants for first time

Genetically modified pig kidneys have kept two kidney failure patients alive long enough to receive human organ transplants for the first time, according to biotech company EGenesis. Tim Andrews, a 66-year-old from New Hampshire, received a modified pig kidney in January 2025. The organ functioned for about nine months before failing, but kept him stable enough to survive until a human kidney became available. Andrews, who had been told he would likely die before receiving a transplant, felt immediate improvement after the pig kidney procedure. He could walk around freely without dialysis and regained his energy. EGenesis says a second patient also received a pig kidney that served as a successful bridge to a human transplant. The company hopes to make the organs widely available within approximately four years, pending further testing.

15th Rock
Sep 4th, 2026
Hokkaido University and 15th Rock Launch the Hokkaido University Green Frontier Fund

Hokkaido University and 15th Rock Launch the Hokkaido University Green Frontier Fund 15th Rock has invested in eGenesis, Inc. and Metagen Therapeutics, Inc.

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