Encoded Therapeutics develops precision gene therapies for pediatric central nervous system disorders, including Dravet syndrome. Its therapies use a unique targeting and regulation platform to deliver genetic payloads to specific brain cell types based on genetic profiles, increasing gene specificity, cell selectivity, and potency. The company aims to distinguish itself by focusing on cell-type–specific brain targeting and safety in pediatric patients to reduce off-target effects and toxicity compared with earlier gene therapies. Its goal is to bring clinically effective treatments to patients and work with healthcare providers to commercialize these therapies.
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Industries
Company Size
51-200
Company Stage
Series F
Total Funding
$514.1M
Headquarters
San Francisco, California
Founded
2014
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Total Funding
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Funding rounds for AI training, fintech AI, robotics services and biotech firms. Recent Series A and later-stage financings across AI, robotics and biotech illustrate capital allocation to specialised training environments, fintech decisioning, outcome-based automation and RNA-based therapeutics. Artificial intelligence. Synapse Analytics, an Abu Dhabi-based AI company that provides agentic decision-making infrastructure for regulated lenders, raised $13 million in a Series A led by Paris-based Partech, with participation from Cairo's Algebra Ventures and Silicon Badia. The funding lifts total capital to $17 million and will be used to enlarge the engineering team, accelerate product development for credit-risk decisioning, and expand the firm's presence across the Middle East, Africa and Latin America, where it reports a more than five-fold revenue increase since its 2025 relaunch. [6] Anew Labs, the AI-driven drug-discovery unit spun out of ByteDance, completed a Series A valued at $290 million according to Dealroom, with the round led by HSG, IDG Capital and Hillhouse Investment and co-lead by 5Y Capital, alongside participation from Gaorong Ventures, Primavera Venture Partners and several state-backed funds. The financing will support development of its structure-prediction and protein-design models, Protenix and PXDesign, and advance four drug candidates, while ByteDance retains a 56 percent stake. [5] Robotics. Extend Robotics, a UK-based embodied-AI firm that sells completed factory work rather than robots, closed a £2.6 million early-stage round led by Skyworks Venture Capital Fund, with participation from Neo Venture (Europe) and Zip Capital. The money will be used to scale its Result-as-a-Service offering across the UK and Europe, expand its remote-operator network and grow the AMAS platform that lets non-robotics specialists control robot arms or humanoids via an immersive 3D interface, with AI handling routine task portions. [1] Tangent Robotics, a New York spin-out of Columbia University's Robotic Manipulation and Mobility Lab, raised $4.5 million in pre-seed funding led by Fly Ventures and Toyota Ventures. The capital will support development of its fine-motor-skill layer that combines light-based touch sensors, human-motion-tracked robotic hands and machine-learning-driven motor learning, targeting high-precision assembly, threading and connector-mating tasks in manufacturing. Co-founders Pedro Piacenza and Matei Ciocarlie highlighted the aim to reduce robot skill acquisition time from days to hours. [2] RobotPlusPlus (ROBOT++) completed a Series C described as "hundreds of millions of RMB (tens of millions of USD)" led by Qianggang Capital Fund, with participation from GIG Capital Group, Sealand Innovation, Juntong Capital and an increased stake by Fosun RZ Capital. The round will fund global expansion of its special-purpose industrial robots, including hull-derusting fleets deployed in over 100 shipyards, and further embodied-AI development for hazardous tasks across shipyards, oil-and-gas sites, wind farms and building façades, leveraging its R&D-heavy model that has amassed over 2 million operating hours. [3] Genetic engineering. Innovate UK announced the Engineering Biology Investor Partnerships Round 1, offering up to £8 million in grant funding to UK-registered SMEs developing engineering-biology products and services, with the requirement that applicants secure aligned investment from a lead investor in the programme's pool. Grants range from £250 000 to £2 million for projects of 24-month duration, aiming to support late-stage experimental development and commercialisation of engineering-biology technologies, with additional commercial expertise provided by participating investors. [4] Encoded Therapeutics, a South San Francisco company that creates one-time precision genetic medicines for severe neurological disorders, raised $275 million in a Series F co-led by GV and a healthcare fund, with participation from ARCH Venture Partners, Braidwell, Farallon Capital Management, Illumina Ventures, Invus, Janus Henderson, Matrix Capital, Nolan Capital, RTW Investments, SoftBank Vision Fund 2 and Venrock. Proceeds will fund a pivotal study of ETX101 in infants and children with SCN1A-positive Dravet syndrome, an expansion study up to age 18, scale-up of GMP manufacturing and advancement of ETX301 toward a 2027 IND submission for post-amputation neuroma pain. [5]
Encoded raises $275m for Dravet therapy and other financings. Right after reporting encouraging data with its Dravet syndrome gene therapy, Encoded Therapeutics has raised an impressive $275 million to take the programme into a pivotal trial. At the European Epilepsy Congress (EEC) this week, Encoded showcased results of the phase 1/2 POLARIS trial of ETX101 in Dravet syndrome associated with mutations in the SCN1A gene, including a big reduction in seizure frequency - compared to historical controls - in the 12 months after the one-shot therapy. Dravet syndrome is a severe form of developmental and epileptic encephalopathy that begins in infancy and causes prolonged seizures that do not respond well to current anticonvulsant drugs, as well as behavioural and developmental delays. Treatment with ETX101 was also associated with "encouraging" developmental gains among subjects in POLARIS, according to the South San Francisco company. The new financing, co-led by GV and another unidentified healthcare fund, will also fund the scale-up of manufacturing for ETX101 for forthcoming trials, as well as development of a second drug candidate - codenamed ETX301 - that Encoded has in preclinical testing for post-amputation neuroma pain. The financing was also supported by ARCH Venture Partners, Braidwell LP, Farallon Capital Management, Illumina Ventures, Invus, Janus Henderson Investors, Matrix Capital Management, Nolan Capital, RTW Investments, SoftBank Vision Fund 2, and Venrock. Other recent financing rounds. Also this week, Seattle start-up Brainchild Bio closed a $116 million Series A round earmarked for clinical trials of its CAR-T therapies for central nervous system cancers, headed by BCB-276, a B7-H3-targeted therapy for rare and aggressive paediatric tumour diffuse intrinsic pontine glioma (DIPG). The therapy is currently in the phase 2 ILLUMINATE study, with results due in 2028. An undisclosed private family fund and foundation led the round, with participation from the company's seed investor, Seattle Children's Hospital, and new investor WRF Capital. Meanwhile, south San Francisco-based Moonwalk Biosciences, which specialises in RNA interference drugs for obesity and cardiometabolic diseases, added to its coffers with a $70 million second round co-led by Alpha Wave and YK Bioventures and backed by Eli Lilly, Gaorong Ventures, and existing investors ARCH Venture Partners, Khosla Ventures, and Future Ventures. Armed with the new cash, Moonwalk plans to take its lead drug, MW101 for obesity, into phase 1 testing before the end of next year. The drug, which uses adipose-selective delivery chemistry licensed from China's Suzhou Siran Biotechnology, acts via an undisclosed, non-incretin mechanism that could differentiate it from GLP-1 agonist therapies for weight loss. TwoStep Therapeutics raised $62.5 million in a Series A, providing the resources needed to take its lead peptide-drug conjugate programme, TS-104, into clinical testing for solid tumours. According to San Carlos, California-based TwoStep, TS-104 uses a polyspecific integrin-binding peptide (PIP) that binds to multiple integrins found on solid tumours, delivering a cell-killing MMAE payload. Insight Partners and Medical Excellence Capital acted as co-lead investors, with Merck KGaA's VC arm M Ventures and Pfizer Ventures also taking a prominent role, with existing backers NFX, 2048 Ventures, and Stanford University also participating. Kura Oncology has spun out a new biotech, Caspian Therapeutics, that will develop its menin inhibitor technology outside cancer with the help of $50 million in financing from BVF Partners, supported by Eli Lilly, the T1D Fund, Invus, Montanova Capital, and Kura - which is retaining a half-share in the start-up. Caspian's lead asset is KO-7246, a menin inhibitor currently in preclinical development that could have potential in type 1 and type 2 diabetes and other cardiometabolic disorders by encouraging the expansion of insulin-producing beta cells in the pancreas. The new San Diego biotech said it plans to file for approval to start human trials of KO-7246 "as soon as practicable." Finally this week, New Haven, Connecticut's Cloverleaf Bio has emerged with $33 million in seed financing and a mission to develop a novel class of engineered transfer RNA (tRNA) based payloads for cancer. Its lead programmes - both in preclinical development - are CLB-001, an inhibitory tRNA asset targeting hepatocellular carcinoma, and an antibody-tRNA conjugate (ATC) asset for colorectal cancer. The round was led by 4BIO Capital with backup from AbbVie Ventures, Eli Lilly, and Boehringer Ingelheim Venture Fund, alongside Draper Associates, Mission BioCapital, and American Cancer Society BrightEdge. 11 September, 2026
Encoded raises $275 million to push Dravet gene therapy into pivotal testing. 10 September 2026 US biotech company Encoded Therapeutics has closed a $275 million series F financing that will fund pivotal testing of ETX101, a gene therapy for Dravet syndrome, a severe form of childhood epilepsy. The privately held South San Francisco firm announced the round on Wednesday, days after presenting updated trial data at the European Epilepsy Congress. The financing was co-led by GV, the venture arm of Alphabet (Nasdaq: GOOGL), and a healthcare fund that was not named. Others taking part included ARCH Venture Partners, Braidwell, Farallon Capital Management, Illumina Ventures, Invus, Janus Henderson Investors (NYSE: JHG), Matrix Capital Management, Nolan Capital, RTW Investments, SoftBank Vision Fund 2 and Venrock. This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here. Try before you buy Free. 7 day trial access * All the news that moves the needle in pharma and biotech * Exclusive features, podcasts, interviews, data analyses and commentary from its global network of life sciences reporters. * Receive The Pharma Letter daily news bulletin, free forever. Become a subscriber £820. Or £77 per month * Unfettered access to industry-leading news, commentary and analysis in pharma and biotech. * Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results. * Daily roundup of key events in pharma and biotech. * Monthly in-depth briefings on Boardroom appointments and M&A news. * Choose from a cost-effective annual package or a flexible monthly subscription The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It's part of the key information for keeping me informed Chairman, Sanofi Aventis UK More on this story... 26 August 2026 7 September 2026 Companies featured in this story. Sign up to receive email updates Join industry leaders for a daily roundup of biotech & pharma news Today's issue. 10 September 2026 Company spotlight. A biotechnology company developing precision gene therapies for a broad range of severe genetic disorders. More features in biotechnology. 10 September 2026
Encoded Therapeutics has closed a $275 million Series F financing round co-led by GV and another healthcare fund. The clinical-stage biotechnology company develops precision genetic medicines for severe neurological disorders. The proceeds will fund a pivotal study of ETX101 in infants and young children with SCN1A+ Dravet syndrome, plus an expansion study for children and adolescents up to 18 years. The funding will also support commercial-scale GMP manufacturing and pipeline advancement, including ETX301 towards a 2027 Investigational New Drug submission for post-amputation neuroma pain. Participating investors include ARCH Venture Partners, Braidwell LP, Farallon Capital Management, Illumina Ventures, Invus, Janus Henderson Investors, Matrix Capital Management, Nolan Capital, RTW Investments, SoftBank Vision Fund 2, and Venrock.
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Encoded Therapeutics Inc., a biotechnology company developing genetic medicines for severe central nervous system (CNS) disorders, today highlights oral and poster presentations on the Company’s preclinical gene therapy programs and vector engineering platform at the 27th ASGCT Annual Meeting being held May 7 – 11, 2024 in Baltimore, MD.“ We are thrilled to share multiple advancements across our portfolio of precision genetic medicines, showcasing substantial progress across various fronts. These data underscore our platform’s potential to deliver precision therapies for a range of CNS diseases,” said Stephanie Tagliatela, Chief Scientific Officer at Encoded. “ Alongside clinical advancement of our lead program, ETX101 for SCN1A+ Dravet syndrome, we are poised to nominate multiple programs to development in 2025, marking yet another significant milestone.”Oral PresentationTitle: GABA Selective AAV-mediated Gene Therapy Provides Durable Seizure Protection in Multiple Refractory Epilepsy Models (Abstract #19)Session: AAV Vectors - Preclinical and Proof-of-Concept: Therapy FocusDate & Time: Tuesday, May 7, 1:45–2:00 p.m. ETLocation: Ballroom 2Epilepsy affects approximately 1% of the population, with nearly one third of cases failing to respond to first- and second-line treatments. Encoded’s vector engineering platform has enabled the development of GABA-selective AAV-mediated gene therapies designed to potentiate GABAergic neurotransmission and modulate the circuit dysfunction underlying refractory epilepsies. Our lead candidate reduced seizure incidence and severity in two biologically distinct seizure assays with no adverse impact on body weight, motor function or locomotion
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Industries
Company Size
51-200
Company Stage
Series F
Total Funding
$514.1M
Headquarters
San Francisco, California
Founded
2014
Find jobs on Simplify and start your career today