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Entrada Therapeutics

Develops intracellular therapeutics using endosomal escape

Overview

Entrada Therapeutics focuses on developing a new class of medicines to treat devastating diseases by delivering therapies inside cells. Its core technology, the Endosomal Escape Vehicle (EEV) platform, helps drugs escape from endosomes—cellular compartments that often trap or degrade treatments—so they can reach intracellular targets. The product pipeline centers on EEV-therapeutics, including candidates for Duchenne muscular dystrophy and other neuromuscular diseases, with ENTR-601-45 currently cleared by UK and EU regulators to begin clinical trials. What sets Entrada apart is its explicit emphasis on enabling intracellular delivery to access targets that were previously hard to treat, using a platform-agnostic delivery approach that can work with a range of therapeutics such as oligonucleotides. The company’s goal is to advance multiple EEV-therapeutics through clinical development to address rare and other hard-to-treat diseases and reach patients who need new treatment options.

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About Entrada Therapeutics

Simplify's Rating
Why Entrada Therapeutics is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

201-500

Company Stage

IPO

Headquarters

Boston, MA

Founded

2016

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What believers are saying

  • November 5, 2026 cash of $193 million funds operations into Q4 2027.
  • October 2026 ELEVATE-45-201 met safety goals, and FDA granted orphan designation.
  • Cohort 3 at 18 mg/kg started after DMC review, creating a near-term catalyst.

What critics are saying

  • May 2026 ENTR-601-44 dystrophin rose only 2.36%, undermining platform credibility.
  • Revenue stayed $0.9 million in Q3 2026, leaving total dependence on capital markets.
  • If ELEVATE-44-201 Cohort 2 disappoints in Q1 2027, TRDA loses lead-program conviction.

What makes Entrada Therapeutics unique

  • Entrada’s EEV platform targets intracellular delivery, differentiating it from standard exon-skipping rivals.
  • October 2026 ENTR-601-45 data validated platform repeatability across exon 44 and 45 programs.
  • Vertex partnership on VX-670 extends Entrada beyond its own Duchenne pipeline.

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Funding

Total Funding

$483.1M

Above

Industry Average

Funded Over

6 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison Coming Soon

Benefits

  • 401(k) Company Match
  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Life Insurance
  • Disability Insurance
  • Health Savings Account/Flexible Spending Account
  • Unlimited Paid Time Off
  • Flexible Work Hours
  • Remote Work Options
  • Paid Vacation
  • Paid Sick Leave

Stock Price

Growth & Insights and Company News

6 month growth

1%

1 year growth

0%

2 year growth

1%
Associated Press
Nov 5th, 2026
Entrada's Q3 net loss narrows to $39.7M; $193M cash funds operations into Q4 2027

Entrada Therapeutics reported a third-quarter 2026 net loss of $39.7 million, down from $44.1 million a year earlier. Cash, cash equivalents and marketable securities stood at $193.0 million on September 30, 2026, which the company expects will fund operations into the fourth quarter of 2027. Collaboration revenue fell to $0.9 million from $1.6 million. Research and development expenses dropped to $32.4 million from $38.4 million. In October, the Boston-based company said Cohort 1 of its ELEVATE-45-201 Duchenne muscular dystrophy study met its primary safety and tolerability goals at 5 mg/kg. Data from ELEVATE-44-201 Cohort 1 is due by year-end 2026, and Cohort 2 data is expected in the first quarter of 2027.

Associated Press
Oct 21st, 2026
Entrada Therapeutics appoints KalVista veteran Linea Aspesi as chief people officer

Entrada Therapeutics (Nasdaq: TRDA) has appointed Linea Aspesi as chief people officer. The Boston-based biopharmaceutical company announced the move on October 21, 2026. Aspesi has more than 20 years of experience in culture transformation at biopharmaceutical and technology companies. She was previously chief people officer at KalVista Pharmaceuticals and held senior human resources roles at Editas Medicine, Forma Therapeutics, Saniona, Sobi, and Genzyme Biologics Manufacturing. Chief executive officer Dipal Doshi said the company is in a "catalyst-rich period" with its neuromuscular programmes. He said Aspesi's experience will help build a culture that lets staff deliver on the pipeline's potential.

GlobeNewswire
Oct 21st, 2026
Entrada Therapeutics appoints Linea Aspesi as Chief People Officer.

Entrada Therapeutics appoints Linea Aspesi as Chief People Officer. A seasoned global people leader and organizational strategist, Ms. Aspesi will help scale Entrada's people and organization for its next phase of growth. BOSTON, Oct. 21, 2026 (GLOBE NEWSWIRE) - Entrada Therapeutics, Inc. (Nasdaq: TRDA) today announced the appointment of Linea Aspesi as Chief People Officer. "Linea has a proven track record of scaling organizations and developing high-performing teams from discovery through commercial stages," said Dipal Doshi, Chief Executive Officer at Entrada Therapeutics. "We are in a catalyst-rich period with our neuromuscular programs, and Linea brings deep experience that will be invaluable as we continue to build an industry-leading culture that enables Entradans to do their best work and deliver on the potential of our pipeline. People are the foundation of any organization, and at Entrada, we know that a strong and engaged team is critical to our ability to develop a new class of genetic medicines and ultimately bring them to the patients who need them most." "Entrada is a company with a clear and steady commitment to patients and to one another," said Ms. Aspesi. "I'm thrilled to join the team at such an important time in Entrada's growth and look forward to building on its strong, mission-driven culture and fostering an environment where our colleagues can continue to do their best work as we grow and advance our pipeline for patients." Ms. Aspesi is an organizational leader with more than twenty years of experience driving culture transformation at biopharmaceutical and technology companies ranging from small-cap to Fortune 500. With a focus on scaling organizations from discovery through commercial stages, she has led companies through critical inflection points while executing culture strategies that put people first and drive employee engagement and retention. Prior to Entrada, Ms. Aspesi served as Chief People Officer at KalVista Pharmaceuticals (acquired by Chiesi Group) and held multiple executive-level human resources leadership roles at life science companies including Editas Medicine, Forma Therapeutics, Inc. (acquired by Novo Nordisk), Saniona, Inc., Sobi, Inc., and Genzyme Biologics Manufacturing (acquired by Sanofi). Ms. Aspesi holds a BA in Education from the University of Massachusetts, Amherst. About Entrada Therapeutics Entrada Therapeutics is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of genetic medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary, versatile and modular approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. The Company's lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1. Forward-Looking Statements This press release contains express and implied forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release, including statements regarding Entrada's strategy, future operations, prospects and plans, objectives of management, the validation and differentiation of Entrada's approach and EEV platform and its ability to advance its programs and provide a potential treatment for patients, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "might," "objective," "ongoing," "plan," "predict," "project," "potential," "should," or "would," or the negative of these terms, or other comparable terminology are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Entrada may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including the risks and uncertainties identified in Entrada's filings with the Securities and Exchange Commission (SEC), including the Company's most recent Form 10-K and in subsequent filings Entrada may make with the SEC. In addition, the forward-looking statements included in this press release represent Entrada's views as of the date of this press release. Entrada anticipates that subsequent events and developments will cause its views to change. However, while Entrada may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Entrada's views as of any date subsequent to the date of this press release. Media Contact Megan Prock McGrath CTD Comms, LLC [email protected] Investor Contact Doug Snow Head of Investor Relations [email protected]

MarketBeat
Sep 3rd, 2026
Entrada Therapeutics (NASDAQ:TRDA) major shareholder sells $180,691.89 in stock.

Entrada Therapeutics (NASDAQ:TRDA) major shareholder sells $180,691.89 in stock. September 3, 2026 Key points. * Major shareholder Bioventures 2018 L.P. Mpm sold 25,131 Entrada Therapeutics shares at an average $7.19, generating $180,691.89. The sale reduced its ownership by 0.60%, leaving it with 4.18 million shares worth approximately $30.0 million. * The shareholder has also sold additional shares in a series of recent transactions, totaling more than 173,000 shares from August 27 through September 3. * Entrada shares fell 1.8% to $7.17, while the company recently reported a quarterly loss of $1.01 per share and revenue of $0.90 million, both weaker than analyst expectations. Analysts nevertheless maintain a "Moderate Buy" consensus with a $17.75 price target. * Five stocks we like better than Entrada Therapeutics. Entrada Therapeutics, Inc. (NASDAQ:TRDA - Get Free Report) major shareholder Bioventures 2018 L.P. Mpm sold 25,131 shares of the stock in a transaction on Wednesday, September 2nd. The shares were sold at an average price of $7.19, for a total value of $180,691.89. Following the completion of the sale, the insider owned 4,177,215 shares in the company, valued at approximately $30,034,175.85. The trade was a 0.60% decrease in their ownership of the stock. The sale was disclosed in a filing with the SEC, which is available at the SEC website. Large shareholders that own 10% or more of a company's shares are required to disclose their transactions with the SEC. Bioventures 2018 L.P. Mpm also recently made the following trade(s): * On Thursday, September 3rd, Bioventures 2018 L.P. Mpm sold 32,263 shares of Entrada Therapeutics stock. The stock was sold at an average price of $7.17, for a total value of $231,325.71. * On Tuesday, September 1st, Bioventures 2018 L.P. Mpm sold 29,088 shares of Entrada Therapeutics stock. The stock was sold at an average price of $7.06, for a total value of $205,361.28. * On Monday, August 31st, Bioventures 2018 L.P. Mpm sold 44,259 shares of Entrada Therapeutics stock. The shares were sold at an average price of $6.99, for a total value of $309,370.41. * On Friday, August 28th, Bioventures 2018 L.P. Mpm sold 3,733 shares of Entrada Therapeutics stock. The stock was sold at an average price of $7.01, for a total value of $26,168.33. * On Thursday, August 27th, Bioventures 2018 L.P. Mpm sold 38,922 shares of Entrada Therapeutics stock. The shares were sold at an average price of $7.20, for a total transaction of $280,238.40. Entrada Therapeutics stock down 1.8%. Entrada Therapeutics stock traded down $0.13 during trading on Thursday, reaching $7.17. The stock had a trading volume of 395,559 shares, compared to its average volume of 255,201. Entrada Therapeutics, Inc. has a 52-week low of $5.02 and a 52-week high of $16.45. The stock has a market cap of $279.20 million, a PE ratio of -1.81 and a beta of -0.25. The business has a 50 day moving average price of $7.08 and a 200 day moving average price of $9.20. Discover more Cryptocurrency News Compare Investment Apps Entrada Therapeutics (NASDAQ:TRDA - Get Free Report) last announced its quarterly earnings data on Wednesday, August 5th. The company reported ($1.01) earnings per share for the quarter, missing analysts' consensus estimates of ($0.97) by ($0.04). The firm had revenue of $0.90 million during the quarter, compared to analyst estimates of $2.32 million. Entrada Therapeutics had a negative net margin of 3,537.73% and a negative return on equity of 57.61%. On average, equities analysts predict that Entrada Therapeutics, Inc. will post -4.03 EPS for the current fiscal year. Wall Street analysts forecast growth. Several analysts have recently weighed in on TRDA shares. Roth Capital reissued a "buy" rating and issued a $11.00 target price on shares of Entrada Therapeutics in a report on Wednesday, August 12th. Weiss Ratings raised shares of Entrada Therapeutics from a "sell (e+)" rating to a "sell (d-)" rating in a report on Monday. Guggenheim lowered their price target on Entrada Therapeutics from $20.00 to $17.00 and set a "buy" rating on the stock in a report on Monday, June 8th. Finally, HC Wainwright downgraded Entrada Therapeutics from a "buy" rating to a "neutral" rating in a research note on Friday, May 8th. Four analysts have rated the stock with a Buy rating, one has issued a Hold rating and one has issued a Sell rating to the company's stock. Based on data from MarketBeat, the company currently has a consensus rating of "Moderate Buy" and a consensus price target of $17.75. Hedge funds weigh in on Entrada Therapeutics. Large investors have recently made changes to their positions in the stock. State of Wyoming purchased a new position in Entrada Therapeutics in the second quarter valued at about $37,000. Russell Investments Group Ltd. raised its holdings in Entrada Therapeutics by 72.7% during the third quarter. Russell Investments Group Ltd. now owns 8,808 shares of the company's stock worth $51,000 after purchasing an additional 3,707 shares during the last quarter. Occudo Quantitative Strategies LP acquired a new stake in Entrada Therapeutics in the second quarter valued at $68,000. Jain Global LLC purchased a new position in shares of Entrada Therapeutics in the third quarter valued at $69,000. Finally, IHT Wealth Management LLC acquired a new stake in Entrada Therapeutics in the 2nd quarter valued at about $72,000. Hedge funds and other institutional investors own 86.39% of the company's stock. About Entrada Therapeutics. Entrada Therapeutics NASDAQ: TRDA is a clinical-stage biotechnology company focused on enabling the development of protein-based therapeutics that can cross cell membranes and engage intracellular targets. Using its proprietary cell-penetrating miniature protein (CPMP) platform and intracellular targeting of proteins (iTOP) delivery technology, Entrada aims to expand the range of diseases addressable by large-molecule drugs. The company's pipeline includes programs in rare and serious diseases where conventional biologics have limited intracellular activity. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Entrada Therapeutics, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Entrada Therapeutics wasn't on the list. While Entrada Therapeutics currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys. The AI boom is creating opportunities across semiconductors, cloud computing, enterprise software, infrastructure, cybersecurity, and automation. Inside this report, you'll find 10 companies positioned to benefit as artificial intelligence moves from hype to real-world deployment and becomes a core growth driver for corporate America.

Associated Press
Aug 5th, 2026
Entrada Therapeutics reports Q2 2026 results with multiple DMD data readouts ahead

Entrada Therapeutics reported second quarter 2026 financial results, highlighting multiple upcoming clinical data readouts for its Duchenne muscular dystrophy programmes. The company expects to report ELEVATE-44-201 Cohort 1 open-label data by year-end 2026 and Cohort 2 data in Q1 2027. ELEVATE-45-201 Cohort 1 results are anticipated in October 2026. Cash, cash equivalents and marketable securities totalled $223.0 million as of 30 June 2026, down from $295.7 million at year-end 2025. The company expects these funds to support operations into Q3 2027. Net loss was $42.8 million for the quarter, compared to $43.1 million in the same period last year. Research and development expenses decreased to $35.4 million from $37.9 million year-on-year. The company also received UK regulatory authorisation to initiate a Phase 1/2 study of ENTR-601-50 in DMD patients amenable to exon 50 skipping.

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