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GreenLight Biosciences

Develops RNA-based agricultural pest control

Overview

GreenLight Biosciences develops RNA-based solutions for agriculture and health, aiming to improve crop productivity and protect crops from pests while promoting environmental sustainability. Its products work by using RNA to silence or disrupt specific genes in pests or target organisms, delivered through formulations that can be sprayed or applied to fields, creating a targeted pest-management approach. The company differentiates itself by focusing on RNA technology as a platform to deliver precise, species-specific effects that reduce chemical inputs and support sustainable farming, unlike traditional chemical pesticides. Its goal is to advance RNA technologies to enable sustainable agriculture and healthier outcomes for both crops and people, positioning itself as a leader in bioscience focused on real-world agricultural impact.

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About GreenLight Biosciences

Simplify's Rating
Why GreenLight Biosciences is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Food & AgricultureBiotechnology

Company Size

51-200

Company Stage

IPO

Headquarters

Medford, MA

Founded

2008

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What believers are saying

  • Mexico authorized Oifirax on August 25, 2026, validating GreenLight’s regulatory path.
  • Brazil included Oifirax on its priority review list in June 2026, accelerating market entry.
  • Just Climate’s $25 million June 2026 financing funded Brazil expansion and a Mexico City plant.

What critics are saying

  • A July 24, 2023 merger lawsuit settled for $2 million, signaling governance baggage into 2026.
  • Oifirax still depends on regulatory execution and field efficacy; delays in Brazil or Europe stall revenue.
  • If products underperform at scale, GreenLight remains a platform story with no durable commercial moat.

What makes GreenLight Biosciences unique

  • GreenLight commercialized the first RNA-based fungicide, Oifirax, in Mexico on August 25, 2026.
  • Its Rochester facility claims 500 kilograms annual RNA capacity, scaling to 1,000 kilograms by 2026.
  • Cell-free dsRNA manufacturing gives GreenLight cheaper, faster sequence-specific crop protection than conventional chemistries.

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Funding

Total Funding

$584M

Above

Industry Average

Funded Over

12 Rounds

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Benefits

  • Paid Vacation

Growth & Insights and Company News

6 month growth

-3%

1 year growth

-9%

2 year growth

-9%
Ontario Pest Management Conference
Oct 13th, 2026
Speaker spotlight #3: A new kind of crop protection.

Speaker spotlight #3: A new kind of crop protection. What if the next generation of crop protection could be designed with precision at the molecular level? At the 2026 Ontario Pest Management Conference, Wayne Barton, Development & Tech Services Consultant with GreenLight Biosciences Inc., will explore one of the emerging technologies that could help shape the future of the IPM toolbox: RNA interference (RNAi). RNAi uses targeted delivery of double-stranded RNA (dsRNA) to interfere with specific biological processes in pests. Its highly targeted nature, short environmental half-life and potential for reduced effects on beneficial organisms and other non-targets make it a particularly interesting approach to crop protection. But promising technology doesn't automatically translate into reliable field performance. Wayne's presentation will look at where RNAi and dsRNA technologies are being used today - and what needs to happen for them to move beyond a small number of novel products toward a broader crop protection platform. That means tackling some very practical questions: How do Ontario Pest Management Conference select effective targets? How can dsRNA be produced economically? How do Ontario Pest Management Conference formulate and deliver it effectively? How do Ontario Pest Management Conference achieve sufficient uptake, persistence and consistency under real-world field conditions? And what will regulatory science need to consider as the technology develops? As growers face a shrinking selection of conventional active ingredients, technologies like RNAi offer a glimpse at what a very different kind of crop protection toolbox could look like. Meet Wayne Barton. Wayne Barton is a Development & Tech Services Consultant with GreenLight Biosciences Inc., where he is focused on the development of their dsRNA crop protection pipeline. A graduate of the University of Guelph with a BSc (Agr) and MSc in plant pathology, Wayne spent 26 years with BASF Canada in crop protection field research, marketing and R&D leadership, following earlier consulting work in crop residue, soil dissipation and efficacy. His career has spanned both the practical and technical sides of crop protection - and now, he is working at the forefront of an emerging technology with the potential to add an entirely new dimension to the IPM toolbox. From molecules to messages, the next generation of crop protection may work very differently. Join Wayne and its other plenary speakers at the 2026 Ontario Pest Management Conference on November 3 in Guelph ON as Ontario Pest Management Conference explore The Next IPM Toolbox: Finding Tomorrow's Solutions. 2026 Ontario Pest Management Conference From CA$40.00 November 3, 2026, 8:30 a.m.-4:30 p.m. Victoria Park East Golf Club

AgroPages.com
Aug 25th, 2026
Mexico authorizes GreenLight's RNA-based biofungicide OIFIRAX.

Mexico authorizes GreenLight's RNA-based biofungicide OIFIRAX. Aug. 25, 2026 Mexico has authorized what GreenLight Biosciences describes as the world's first commercially registered RNA-based biofungicide, marking a significant development in the use of RNA technology for the management of agricultural diseases. The product, OIFIRAX, was authorized by Mexico's Federal Commission for the Protection against Health Risks (COFEPRIS) for the control of grape powdery mildew, caused by Erysiphe necator. The disease, also known as powdery mildew, affects leaves, shoots and fruit and can reduce photosynthesis, the quality of grapes and vineyard yields when left unmanaged. The registration was evaluated jointly by COFEPRIS, Mexico's National Service for Agro-Alimentary Public Health, Safety and Quality (SENASICA), and the Secretariat of Environment and Natural Resources (SEMARNAT). According to information released during the authorization announcement, the complete regulatory dossier was approved in approximately nine months. GreenLight said the registration follows more than 10 years of research and testing conducted in Mexico and other countries. RNA technology targets fungal pathogen OIFIRAX is based upon double-stranded RNA (dsRNA) molecules designed to temporarily block an essential gene involved in the development of the target fungus. The technology is based upon a sequence-specific mechanism intended to interfere with the pathogen, while leaving the plant's normal biological processes unaffected. OIFIRAX does not modify the DNA of the crop and therefore does not make the plant a genetically modified organism. The selectivity of the approach is one of the technology's main potential advantages. By targeting a specific genetic sequence, RNA-based crop protection products can potentially reduce exposure to non-target organisms, including bees, butterflies and beneficial soil microorganisms. The RNA molecules also degrade naturally through enzymes, radiation and processes occurring in soil and water, potentially reducing the risk of environmental accumulation, compared with some conventional pesticides. However, the technology is expected to be used as part of an integrated disease-management program, rather than as a stand-alone solution. Growers will need to follow the authorized label, including application rates, intervals and registered crops. Resistance management remains important Despite the selectivity of the technology, RNA-based disease control will still require monitoring for the development of resistance. Repeated use of a product targeting the same essential gene could create selection pressure on fungal populations, potentially favoring individuals with genetic variations that reduce sensitivity to the treatment. Researchers will also need to continue evaluating the degree of genetic similarity between the targeted sequence and genes occurring in non-target organisms. The commercial deployment of OIFIRAX will therefore provide an important opportunity to generate additional field data on the agronomic and environmental performance of RNA-based fungicides at commercial scale. The registration should also be distinguished from the broader development of RNA-based pesticides. RNA technology had already reached the commercial pesticide market through insect-control products, including Calantha, registered in the United States against the Colorado potato beetle. OIFIRAX represents a different application, with an RNA-based product targeting a fungal pathogen. Investment opportunity in Mexico Beyond its regulatory significance, the authorization could create a new manufacturing and investment platform for RNA-based agricultural technologies in Mexico. GreenLight Biosciences plans to invest between US$50 million and US$100 million in a production facility in Mexico City. GreenLight expects the project to create more than 500 specialized jobs. Additionally, the investment could strengthen Mexico's position in the emerging RNA crop-protection sector while providing GreenLight with local production capacity for a technology that is moving from research and regulatory development toward commercial distribution. The authorization comes as agricultural input companies increasingly explore biological and precision-based alternatives to conventional crop protection. RNA-based products are attracting attention because their mechanism can be designed around specific genetic sequences, potentially enabling a level of target specificity that is difficult to achieve with broad-spectrum chemistries. For the agricultural industry, however, OIFIRAX remains an emerging technology. Its long-term performance, resistance profile and environmental behavior will need to be assessed as its commercial use expands. The Mexican registration nonetheless establishes an important regulatory precedent: for the first time, an RNA-based fungicide has moved beyond experimental development into commercial crop protection, opening a new chapter in the evolution of biological and precision agricultural technologies. (Editing by Leonardo Gottems, reporter for AgroPages)

AgroPages.com
Jun 22nd, 2026
GreenLight Biosciences registers Oifirax, the first RNA-based fungicide, in Brazil.

GreenLight Biosciences registers Oifirax, the first RNA-based fungicide, in Brazil. Jun. 22, 2026 GreenLight Biosciences is positioning Brazil as the strategic launchpad for Oifirax (ES-43), the world's first topical RNA-based fungicide. The move underscores a broader shift in the crop protection industry to focus on highly targeted, residue-free biological solutions capable of matching the efficacy of traditional chemistry. The regulatory pathway for Oifirax gained significant momentum following the publication of Act No. 62 by the Brazilian Ministry of Agriculture (MAPA), which officially included the RNAi bio-input on its priority review list. "This inclusion is a highly positive breakthrough," according to Juliana Di Risio Pelegrino, Regulatory Affairs Manager at GreenLight. "It demonstrates alignment with MAPA to bring cutting-edge innovation and sustainability to the field. We are in constant contact with authorities to ensure approval within the shortest possible timeframe." This regulatory push follows a recent $25 million financial injection from Just Climate, an investment firm linked to Generation Investment Management, founded by Al Gore (former US president). The capital is fueling GreenLight's expansion in Brazil, which will serve as the company's global operational hub for at least the next 40 months. Disrupting Viticulture GreenLight is initially targeting the viticulture sector, where powdery mildew - caused by the fungus Uncinula necator - remains a persistent threat throughout Brazil's 75,000 hectares of vineyards. The disease impacts everything from the table grape clusters of the São Francisco Valley to the wine-producing regions of Rio Grande do Sul. According to GreenLight CEO Matheus Zarur, the choice of grapes as the entry market is highly tactical. For table grapes undergo minimal processing, making stringent residue control paramount for exporters. Meanwhile, in industrial wine production, traditional chemical residues risk interfering with sensitive fermentation processes. Field trials conducted across diverse Brazilian microclimates, including the semi-arid São Francisco Valley, demonstrate that Oifirax delivers control levels equal or superior to conventional chemical fungicides, even at reduced dosages. Beyond grapes, GreenLight plans to expand the label to other high-value crops susceptible to the fungus, such as tomatoes, cucumbers, coffee, and cocoa. The RNAi Mechanism Oifirax utilizes RNA interference (RNAi) technology to silence specific, essential genes within the target fungal cells, halting reproduction. Despite its biotech origins, the product is not classified as a Genetically Modified Organism (GMO), as it does not alter the genetic code of the crop or surrounding organisms. | Feature | Oifirax (RNAi Technology) | Traditional Chemical Pesticides | | Mode of Action | Intracellular gene silencing | Broad-spectrum chemical toxicity | | Environmental Stability | Degrades completely within days | Potential for long-term soil/water persistence | | Non-Target Toxicity | Zero impact on pollinators (bees/ladybugs) | Variable risk to beneficial insects | | Residue Profile | Undetectable at harvest | Subject to strict Maximum Residue Limits (MRLs) | Production of the double-stranded RNA is driven by GreenLight's proprietary cell-free manufacturing platform. This commercial-scale process synthesizes RNA rapidly and cost-effectively, overcoming the historical cost barriers that previously restricted RNAi applications to human therapeutics. A Regional Export Hub While initial manufacturing of the technical active ingredient will occur in the United States, GreenLight intends to transfer production to Brazil in the future. The company's commercial footprint in the country is already anchored by Fortivance, an insecticide adjuvant currently applied across approximately 1 million hectares of Brazilian corn, soybeans, citrus, and cocoa. Brazil currently accounts for roughly 80% of Fortivance's global sales. Looking forward, GreenLight plans to transform its Brazilian structure into a regional export platform, leveraging its local technical and commercial teams to expand into neighboring Chile and Argentina. Regulatory submissions are also underway in the European Union, targeting premier wine-growing regions in Italy, Spain, and southern France. (Editing by Leonardo Gottems, reporter for AgroPages)

New Folden Elevator
Oct 16th, 2025
The Week in AgriFoodTech: Wild Bioscience raises $60m, Starship lands $50m, new EU agrifood grants

The week in agrifoodtech: wild Bioscience raises $60m, starship lands $50m, new EU agrifood grants. Plus: crop protection platform Ascribe Bioscience raises $12 million.

AgriBusiness Global
Sep 26th, 2025
GreenLight Biosciences Launches Norroa, the First RNA-Based Treatment for Varroa Mites

GreenLight Biosciences launches Norroa, the first rna-based treatment for varroa mites.

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