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Guardant Health develops blood-based cancer diagnostics and sells tests to healthcare providers and research institutions. Its flagship product, Guardant360, uses a liquid biopsy to analyze tumor DNA circulating in a patient’s blood to detect mutations and guide treatment decisions for advanced cancer. The company is expanding into early detection and recurrence monitoring, with tests designed to be non-invasive and data-rich for cancer management. Compared with competitors, Guardant Health emphasizes a widely adopted, FDA-approved liquid biopsy platform with broad cancer-type coverage and a focus on providing actionable genomic insights to clinicians. Its goal is to improve cancer outcomes by enabling non-invasive, data-driven decision making across stages of disease and over time.
Industries
Data & Analytics
Biotechnology
Healthcare
Company Size
1,001-5,000
Company Stage
IPO
Headquarters
Palo Alto, California
Founded
2012
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Total Funding
$2.1B
Above
Industry Average
Funded Over
9 Rounds
Professional Development Budget
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A US court has ordered Guardant Health to pay $245.2m to TwinStrand Biosciences and the University of Washington for infringing patented DNA sequencing technologies. The ruling upholds a November 2023 jury verdict finding Guardant liable for using Duplex Sequencing technology without authorisation. The infringement spans 11 Guardant products, including its Guardant360 CDx cancer detection assay. Of the total penalty, $119.4m represents royalties for sales between February 2024 and May 2026. Guardant must also pay ongoing 6% royalties on covered products through March 2033 when the patents expire. TwinStrand spun out from the University of Washington in 2015. Duplex Sequencing achieves 10,000-fold greater accuracy than conventional methods, according to the company. Guardant rejected the decision and plans to appeal. "We strongly disagree with this decision and will promptly be appealing for its overturn," said chief legal officer John Saia.
Final judgement favours TwinStrand in Guardant patent case. TwinStrand Biosciences, a pioneer in Duplex Sequencing technology, has announced that the US District Court for the District of Delaware entered final judgement on 21st August, in favour of TwinStrand and the University of Washington in their patent infringement suit against Guardant Health, Inc. Seattle-based TwinStrand is a precision genomics company advancing highly accurate DNA sequencing through its patented TwinStrand Duplex Sequencing technology, originally developed at the University of Washington. Duplex Sequencing achieves more than 10,000-fold greater accuracy than conventional next-generation sequencing by independently sequencing and comparing both complementary strands of each DNA molecule. The final judgement preserves a November 2023 jury verdict finding that Guardant Health willfully infringed two core patents underlying TwinStrand's Duplex Sequencing technology across 11 royalty-bearing products and services, and awards TwinStrand and the University of Washington more than $245.2 million in damages, accrued royalties, and interest for infringement that occurred through 31st May 2026. The judgement upholds the jury's $83.4 million damages award for infringement through 30th June 2023, and follows the court's 16th June 2026 ruling resolving the parties' post-trial motions. The court awarded an additional $19.5 million in supplemental damages for sales between 1st July 2023 and 5th February 2024, and $119.4 million in accrued royalties at a rate of 6% for sales between 5th February 2024 and 31st May 2026. The court also awarded $22.9 million in pre-judgement and post-judgement interest. In determining past damages, the jury applied a 6% royalty to revenue attributed to the covered products and services, which represented approximately 90% of Guardant Health's total revenue during the relevant infringement period. Going forward, the court has ordered Guardant Health to pay this 6% royalty on sales of the covered products and services adjudicated at trial from 1st June 2026 through expiration of the patents on 15th March 2033, payable quarterly. Interest also continues to accrue on the unpaid judgement. "Duplex Sequencing solved an accuracy problem the sequencing field had worked on for years, and this judgement affirms the jury's finding that Guardant Health built products on that invention without a license," said Chad Waite, Chair of TwinStrand's Board of Directors. "We remained steadfast in our conviction that the facts would prevail, and they have. We intend to see this through and stand firmly behind the intellectual property at the core of our technology." The court previously denied Guardant Health's post-trial efforts to overturn the verdict or obtain a new trial. All of Guardant Health's counterclaims against TwinStrand were either dismissed by the court or withdrawn by Guardant Health before trial. The final judgement also upholds the validity of the asserted claims of both TwinStrand patents at issue in the case, US Patent Nos. 10,287,631 and 10,760,127. In doing so, the court adopted TwinStrand's proposed language on validity over Guardant Health's proposal that no judgement on validity be entered. Patent-related proceedings regarding the patents remain ongoing before the US Patent and Trademark Office and the Patent Trial and Appeal Board, respectively, and neither patent has been invalidated. "We have been confident in these patents since the day they issued," Waite added. "The court's decision to enter judgement in our favour on validity is particularly meaningful and reinforces the strength of our intellectual property at the core of Duplex Sequencing. We will continue to defend these patents and the innovation they protect for the researchers and clinicians worldwide who rely on the accuracy our technology makes possible." 25 August, 2026
TwinStrand Biosciences announces final judgment in patent infringement suit against Guardant Health, awarding TwinStrand and the University of Washington more than $245.2 million in damages, accrued royalties and interest. August 24, 2026 WOBN news, syndication comments off on TwinStrand Biosciences announces final judgment in patent infringement suit against Guardant Health, awarding TwinStrand and the University of Washington more than $245.2 million in damages, accrued royalties and interest. SEATTLE-(BUSINESS WIRE)-TwinStrand Biosciences (TwinStrand), the pioneer in Duplex Sequencing(R) technology, today announced that the U.S. District Court for the District of Delaware entered final judgment on Aug. 21, 2026, in favor of TwinStrand and the University of Washington (UW) in their patent infringement suit against Guardant Health, Inc. (Nasdaq: GH). The final judgment preserves a November 2023 jury verdict finding that Guardant Health willfully infringed two core patents underlying T Click here to view original post
U.S. court orders Guardant to pay $245 million in DNA sequencing patent dispute. By Thomson Reuters Aug 24, 2026 | 7:25 AM Aug 24 (Reuters) - A U.S. court has ordered Guardant Health to pay more than $245.2 million to TwinStrand Biosciences and the University of Washington after finding that the company infringed patents covering DNA sequencing technology, TwinStrand said on Monday. Here are the details: - The U.S. District Court for the District of Delaware entered final judgment on August 21, upholding a 2023 jury verdict that found Guardant had willfully infringed two patents related to TwinStrand's DNA sequencing technology. - The court ordered Guardant to pay a 6% royalty on U.S. sales of 11 products and services found to infringe the patents until they expire in March 2033. - The judgment includes $83.4 million in original damages, $19.5 million in supplemental damages, $119.4 million in accrued royalties, and $22.9 million in pre- and post-judgment interest. - TwinStrand said the products and services covered by the ruling accounted for about 90% of Guardant's revenue during the infringement period. - The products covered by the ruling include Guardant360 CDx, Guardant Reveal, the Shield cancer test and several other cancer testing and genomics services sold by Guardant. - Guardant had sought to overturn the verdict or obtain a new trial, but the court rejected those efforts, TwinStrand said. - The judgment also upheld the validity of the patent claims at issue, TwinStrand said. - TwinStrand's Duplex Sequencing technology is designed to detect rare genetic mutations with greater accuracy than conventional DNA sequencing methods. - TwinStrand said its technology, developed at the University of Washington, is used in cancer research, diagnostics and drug development. (Reporting by Kamal Choudhury in Bengaluru; Editing by Tasim Zahid)
Guardant Health to appeal federal District Court judgment. August 24, 2026 * Current Guardant Reveal, Shield products excluded from final District Court order * Company has validated Guardant360 design improvements to exclude impact of potential royalties PALO ALTO, Calif.-(BUSINESS WIRE)- Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced it will appeal the final judgment from the U.S. District Court for the District of Delaware related to intellectual property claims brought against Guardant by TwinStrand Biosciences, Inc. and University of Washington, with execution of the final judgment and collection of potential royalties stayed pending appeal. "We strongly disagree with this decision and will promptly be appealing for its overturn," said John Saia, Guardant Health Chief Legal Officer. "We have full faith in the strengths and merits of Guardant's intellectual property and R&D and are confident we will ultimately prevail on appeal." Importantly, the order published on Friday regarding the scope of royalties expressly defined the products included as those that existed at the time of the trial in 2023, many of which have been discontinued or significantly upgraded. Based on Guardant's updated technology the current versions of Guardant Reveal and Shield are excluded from the order and potential royalties. In addition, the company has validated design improvements to Guardant360 and related services that would exclude impact of the potential ongoing royalties in the decision. Guardant remains confident that it did not infringe the asserted patents. Both TwinStrand patents have been preliminarily invalidated in the company's ongoing challenges before the U.S. Patent and Trademark Office. Separately, Guardant is pursuing appeals before the U.S. Court of Appeals for the Federal Circuit. About Guardant Health Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook. Guardant Health Forward-Looking Statements This press release contains forward-looking statements within the meaning of federal securities laws, including statements regarding the potential utilities, values, benefits and advantages of Guardant Health's liquid biopsy tests or assays, which involve risks and uncertainties that could cause the actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health's financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operation" and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2025 and in its other reports filed with or furnished to the Securities and Exchange Commission. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health's views as of any date subsequent to the date of this press release.
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Industries
Data & Analytics
Biotechnology
Healthcare
Company Size
1,001-5,000
Company Stage
IPO
Headquarters
Palo Alto, California
Founded
2012
Find jobs on Simplify and start your career today