Halozyme

Halozyme

Licenses ENHANZE enzyme for injectable delivery

Overview

Halozyme focuses on developing and commercializing ENHANZE, a recombinant hyaluronidase enzyme that temporarily breaks down hyaluronan in subcutaneous tissue to facilitate the delivery of injectable drugs. Through licensing its ENHANZE technology to large pharmaceutical companies, Halozyme enables partners to administer higher-volume or less painful subcutaneous injections. The company earns revenue from upfront licensing fees, milestone payments, and royalties on sales of drugs that use ENHANZE. What sets Halozyme apart is its B2B model centered on a proven collaboration strategy with major pharma players like Roche and Janssen, a track record of FDA-approved fixed-dose subcutaneous combinations, and a focused, royalty-based revenue stream tied to partner products. Halozyme’s goal is to expand access to subcutaneous drug delivery by partnering with more pharmaceutical companies and increasing the number of ENHANZE-enabled therapies registered and sold.

Funded Recently

About Halozyme

Simplify's Rating
Why Halozyme is rated
B
Rated B on Competitive Edge
Rated A on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

501-1,000

Company Stage

IPO

Headquarters

San Diego, California

Founded

1998

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Simplify's Take

What believers are saying

  • Q2 2026 revenue hit $481 million, and Halozyme lifted full-year revenue guidance to $1.91 billion.
  • Halozyme signed five new ENHANZE and Hypercon deals in 2026, already beating its annual target.
  • Royalty revenue rose 50% year over year in Q2 2026, supporting a durable cash engine.

What critics are saying

  • Core ENHANZE patents expire in 2029, triggering royalty step-downs for DARZALEX SC and VYVGART Hytrulo.
  • Merck's MDASE litigation over subcutaneous Keytruda continues through 2026; adverse rulings weaken Halozyme's leverage.
  • The September 2026 $1.3 billion convertible refinancing increases leverage and future dilution pressure.

What makes Halozyme unique

  • ENHANZE has ten commercial products across 100+ markets, generating royalty infrastructure Halozyme can scale.
  • Halozyme won first-mover subcutaneous delivery partnerships with Roche, Janssen, Pfizer, and GSK by 2026.
  • Hypercon and Surf Bio extend Halozyme beyond ENHANZE into concentrated biologics and ADCs.

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Funding

Total Funding

$4.3B

Above

Industry Average

Funded Over

13 Rounds

Post IPO Convertible funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Convertible Funding Comparison
Coming Soon

Benefits

Employee Stock Purchase Program

401(k) Company Match

Professional Development Budget

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

2%

1 year growth

0%

2 year growth

-1%
Third News
Sep 18th, 2026
Halozyme Therapeutics prices upsized $1.3B convertible senior notes offering

Halozyme Therapeutics has priced an upsized private offering of $1.3 billion in convertible senior notes due 2026, up from the originally planned $1.05 billion. The San Diego-based biopharmaceutical company's notes will carry a conversion rate of 7.1509 shares per $1,000 principal. The company expects net proceeds of approximately $1.275 billion. It plans to allocate $162.5 million towards capped call transactions to reduce potential stock dilution. The remaining funds will be used to repurchase existing convertible senior notes maturing in 2027 and 2028. The offering is restricted to qualified institutional buyers under the Securities Act of 1933. Halozyme specialises in biopharmaceutical solutions, with its ENHANZE technology improving delivery of injected drugs through partnerships with companies including Roche and Pfizer.

Fierce Biotech
Sep 2nd, 2026
Novartis inks $3.2B subcutaneous drug delivery deal with Alteogen.

Novartis inks $3.2B subcutaneous drug delivery deal with Alteogen. Novartis has struck a deal worth up to $3.2 billion to work with Alteogen on subcutaneous drug delivery, joining Biogen and GSK on the list of drugmakers to pay to access the technology this year. Korea's Alteogen has emerged as a major player in the subcutaneous drug delivery space in recent years. Competing with Halozyme Therapeutics, Alteogen has landed deals with leading drugmakers based on its rival approach to facilitating subcutaneous delivery. Merck & Co. handed Alteogen a big win in 2020 by picking its ALT-B4 technology for the subcutaneous version of Keytruda. Since then, the Korean biopharma company has expanded its star-studded roster of clients. Novartis joined the list on Wednesday, entering into an option and license agreement for ALT-B4. The Swiss drugmaker has multiple options to obtain exclusive rights to develop drugs using the delivery technology. Novartis didn't respond immediately to Fierce Biotech's request for more information about the alliance. The value of the deal could swell to more than $3.2 billion if Novartis exercises all its options and hits all the milestones covered by the agreement. Alteogen's press release makes no mention of an upfront fee, which typically comprises a fraction of its total deal value. Biogen and GSK each paid $20 million upfront as part of deals worth up to $549 million and $265 million, respectively, in milestones. Alteogen disclosed its single-product deal with GSK's Tesaro in January and partnered with Biogen on up to two assets in March. The company unveiled another deal, worth up to $365 million, with an unnamed drugmaker last month. AstraZeneca partnered with Alteogen in 2025. Novartis' earlier explorations of subcutaneous delivery include a 2024 deal with Lindy Biosciences, which saw the Swiss drugmaker pay $20 million upfront to use a suspension technology in medicines against multiple biologic targets. Let Google know we are your trusted source. Add our editorial as a preferred source in your search results.

PR Newswire
Aug 18th, 2026
Halozyme appoints Dannielle Appelhans to its Board of Directors.

Halozyme appoints Dannielle Appelhans to its Board of Directors. Aug 18, 2026, 16:01 ET SAN DIEGO, Aug. 18, 2026 /PRNewswire/ - Halozyme Therapeutics, Inc. (Nasdaq: HALO) ("Halozyme") today announced the election of Dannielle Appelhans to its Board of Directors. Ms. Appelhans brings more than 20 years of executive leadership across the biotechnology and pharmaceutical industries, with deep expertise in operations, manufacturing, and supply chain management. "Dannielle brings a rare combination of operational excellence and manufacturing depth that aligns directly with our growth strategy, and we are delighted to welcome her to the Halozyme board," said Dr. Helen Torley, President and Chief Executive Officer. "As we continue to scale ENHANZE as a compounding platform engine and advance Hypercon and Surf Bio, her experience transforming global operations and executing major partnerships will be a tremendous asset as we deliver on our growth strategy and create meaningful new value for our partners, patients, and shareholders." Ms. Appelhans has served as President and Chief Executive Officer of COUR Pharmaceuticals, a private biotechnology company developing platform-based therapies for autoimmune diseases, since 2023. Under her leadership, the company negotiated and executed a strategic collaboration with Genentech with a potential value of up to $1 billion. Previously, she served as Chief Executive Officer of Rubius Therapeutics, Inc., a publicly traded, clinical-stage biopharmaceutical company. Earlier, she held roles of increasing responsibility at Novartis, culminating as Senior Vice President and Chief Technical Officer of Novartis Gene Therapies, where she led development, manufacturing, and supply chain for the gene therapy unit, including the approved therapy Zolgensma, and as Senior Vice President, Global Head of Supply Chain Management. She began her career at McKinsey & Company and Eli Lilly and Company, and previously served on the Board of Directors of Generation Bio Co. "I am honored to join Halozyme's Board of Directors," said Ms. Appelhans. "Halozyme has built a differentiated, royalty-driven business and a compelling strategy for durable growth through its multiple drug delivery technology platforms. I look forward to working with the board and leadership team to help deliver even greater value to patients and shareholders." Ms. Appelhans earned a Master of Science in mechanical engineering from Massachusetts Institute of Technology's School of Engineering, an MBA from Massachusetts Institute of Technology's Sloan School of Management, and a Bachelor of Science in mechanical engineering from the University of Michigan. About Halozyme Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE(R) drug delivery technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution facilitates the subcutaneous delivery of injected drugs and fluids, reducing treatment burden and improving convenience. ENHANZE(R) has touched more than one million patient lives through ten commercialized products across over 100 global markets and is licensed to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical, Acumen Pharmaceuticals, Merus N.V., Skye Bioscience, GSK and Incyte. Halozyme expanded its drug delivery technology portfolio to develop partner products using Hypercon(TM) and Surf Bio's hyperconcentration technology. Hypercon(TM) is an innovative microparticle technology expected to set a new standard in hyperconcentration of drugs and biologics by reducing injection volume for the same dosage and enabling administration in at-home and healthcare-provider settings. The addition of Surf Bio's polymer-based hyperconcentration technology further broadens the range of biologics that can be delivered subcutaneously, meaningfully expanding the scope of opportunities across therapeutic modalities. Together, Hypercon(TM) and Surf Bio's technology complement ENHANZE(R) by enabling creation and delivery of highly concentrated biologics. The Hypercon(TM) technology has been licensed to leading biopharmaceutical partners, including Janssen, Eli Lilly, argenx, Vertex Pharmaceuticals, and Oruka Therapeutics. Halozyme also develops, manufactures and commercializes drug-device combination products using advanced auto-injector technologies designed to improve convenience, reliability and tolerability, enhancing patient comfort and adherence. The Company has two proprietary commercial products, Hylenex(R) and XYOSTED(R), partnered commercial products and ongoing development programs with Teva Pharmaceuticals and McDermott Laboratories Limited, an affiliate of Viatris Inc. Halozyme is headquartered in San Diego, CA, with offices in Ewing, NJ; Minnetonka, MN; and Boston, MA. Minnetonka is also the site of its operations facility. Forward-Looking Statements This press release may include forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts and may include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential and statements regarding future performance and growth of Halozyme's business. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans", "will be" and similar expressions. Although Halozyme believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Halozyme, that could cause actual results and developments to differ materially from those expressed in the forward-looking information and statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors. These and other factors that may result in differences are discussed in greater detail in the Company's most recently filed Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Halozyme undertakes no obligation to update or revise any forward-looking statements or any other information contained herein. Tram Bui VP, Investor Relations and Corporate Communications 609-333-7668 [email protected] SOURCE Halozyme Therapeutics, Inc.

Yahoo Finance
Aug 15th, 2026
Halozyme beats Q2 estimates by 19%, raises full-year revenue guidance to $1.87B on surging royalties

Halozyme Therapeutics reported strong second-quarter results, beating analyst expectations across key metrics. Revenue reached $481 million, surpassing estimates of $404.3 million, driven by a 50% year-over-year increase in royalty revenue from its ENHANZE platform. The company raised its full-year revenue guidance to $1.87 billion at the midpoint, up from $1.76 billion. Adjusted earnings per share guidance also increased to $8.83 at the midpoint. CEO Helen Torley attributed the outperformance to new collaboration agreements and revenue from six different drugs using the ENHANZE platform. The quarter included significant milestone payments from newly signed licensing deals. Analysts questioned management about royalty revenue acceleration, patent exclusivity impacts, and pipeline launch timing. The company projects five to seven product launches by the mid-2030s, supporting a $1 billion royalty target.

Yahoo Finance
Aug 13th, 2026
Halozyme reports 80% Q2 royalty revenue growth driven by newer subcutaneous drug launches

Halozyme reported exceptionally strong second-quarter 2026 results, driven by ENHANZE royalty revenue growth and new partnership milestones. President and CEO Dr Helen Torley highlighted ENHANZE's performance as a compounding platform engine, demonstrating repeatability, scalability, and revenue durability. The company's newer launch products — Opdivo SC, Ocrevus SC, and Rybrevant SC — showed significant momentum with 80% quarter-on-quarter growth in royalty contributions. These join established products DARZALEX SC, VYVGART Hytrulo, and Phesgo in generating revenue. Halozyme is attracting new partners and additional products from existing collaborators at an accelerating pace. The company also noted that Hypercon, positioned as a second future compounding platform engine, is already showing similar characteristics to ENHANZE whilst applying learnings from the past decade.

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