Halozyme

Halozyme

Licenses ENHANZE enzyme for injectable delivery

Overview

Halozyme focuses on developing and commercializing ENHANZE, a recombinant hyaluronidase enzyme that temporarily breaks down hyaluronan in subcutaneous tissue to facilitate the delivery of injectable drugs. Through licensing its ENHANZE technology to large pharmaceutical companies, Halozyme enables partners to administer higher-volume or less painful subcutaneous injections. The company earns revenue from upfront licensing fees, milestone payments, and royalties on sales of drugs that use ENHANZE. What sets Halozyme apart is its B2B model centered on a proven collaboration strategy with major pharma players like Roche and Janssen, a track record of FDA-approved fixed-dose subcutaneous combinations, and a focused, royalty-based revenue stream tied to partner products. Halozyme’s goal is to expand access to subcutaneous drug delivery by partnering with more pharmaceutical companies and increasing the number of ENHANZE-enabled therapies registered and sold.

About Halozyme

Simplify's Rating
Why Halozyme is rated
C+
Rated B on Competitive Edge
Rated B on Growth Potential
Rated D+ on Differentiation

Industries

Biotechnology

Healthcare

Company Size

501-1,000

Company Stage

IPO

Headquarters

San Diego, California

Founded

1998

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Simplify's Take

What believers are saying

  • Q2 2026 revenue hit $481 million, up 48%, and management raised guidance.
  • Royalties rose 50% year over year as Opdivo SC, Ocrevus SC, Rybrevant SC scaled.
  • August 18, 2026 board pickup added manufacturing veteran Dannielle Appelhans.

What critics are saying

  • Merck invalidated Halozyme patent 11,952,600 on May 12, 2026, weakening Keytruda SC defenses.
  • More than fifteen Merck challenges and ongoing NJ litigation threaten royalty durability through 2027.
  • If ENHANZE rivals win similar fights, Halozyme platform leverage collapses.

What makes Halozyme unique

  • ENHANZE underpins ten commercial products across 100 markets, creating a rare royalty moat.
  • July 20, 2026 Incyte deal added another major pharma partner and optional targets.
  • Hypercon and Surf Bio extend Halozyme beyond ENHANZE into concentrated subcutaneous biologics.

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Funding

Total Funding

$3B

Above

Industry Average

Funded Over

12 Rounds

Post IPO Debt funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Debt Funding Comparison
Coming Soon

Benefits

Employee Stock Purchase Program

401(k) Company Match

Professional Development Budget

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

2%

1 year growth

0%

2 year growth

-1%
PR Newswire
Aug 18th, 2026
Halozyme appoints Dannielle Appelhans to its Board of Directors.

Halozyme appoints Dannielle Appelhans to its Board of Directors. Aug 18, 2026, 16:01 ET SAN DIEGO, Aug. 18, 2026 /PRNewswire/ - Halozyme Therapeutics, Inc. (Nasdaq: HALO) ("Halozyme") today announced the election of Dannielle Appelhans to its Board of Directors. Ms. Appelhans brings more than 20 years of executive leadership across the biotechnology and pharmaceutical industries, with deep expertise in operations, manufacturing, and supply chain management. "Dannielle brings a rare combination of operational excellence and manufacturing depth that aligns directly with our growth strategy, and we are delighted to welcome her to the Halozyme board," said Dr. Helen Torley, President and Chief Executive Officer. "As we continue to scale ENHANZE as a compounding platform engine and advance Hypercon and Surf Bio, her experience transforming global operations and executing major partnerships will be a tremendous asset as we deliver on our growth strategy and create meaningful new value for our partners, patients, and shareholders." Ms. Appelhans has served as President and Chief Executive Officer of COUR Pharmaceuticals, a private biotechnology company developing platform-based therapies for autoimmune diseases, since 2023. Under her leadership, the company negotiated and executed a strategic collaboration with Genentech with a potential value of up to $1 billion. Previously, she served as Chief Executive Officer of Rubius Therapeutics, Inc., a publicly traded, clinical-stage biopharmaceutical company. Earlier, she held roles of increasing responsibility at Novartis, culminating as Senior Vice President and Chief Technical Officer of Novartis Gene Therapies, where she led development, manufacturing, and supply chain for the gene therapy unit, including the approved therapy Zolgensma, and as Senior Vice President, Global Head of Supply Chain Management. She began her career at McKinsey & Company and Eli Lilly and Company, and previously served on the Board of Directors of Generation Bio Co. "I am honored to join Halozyme's Board of Directors," said Ms. Appelhans. "Halozyme has built a differentiated, royalty-driven business and a compelling strategy for durable growth through its multiple drug delivery technology platforms. I look forward to working with the board and leadership team to help deliver even greater value to patients and shareholders." Ms. Appelhans earned a Master of Science in mechanical engineering from Massachusetts Institute of Technology's School of Engineering, an MBA from Massachusetts Institute of Technology's Sloan School of Management, and a Bachelor of Science in mechanical engineering from the University of Michigan. About Halozyme Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE(R) drug delivery technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution facilitates the subcutaneous delivery of injected drugs and fluids, reducing treatment burden and improving convenience. ENHANZE(R) has touched more than one million patient lives through ten commercialized products across over 100 global markets and is licensed to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical, Acumen Pharmaceuticals, Merus N.V., Skye Bioscience, GSK and Incyte. Halozyme expanded its drug delivery technology portfolio to develop partner products using Hypercon(TM) and Surf Bio's hyperconcentration technology. Hypercon(TM) is an innovative microparticle technology expected to set a new standard in hyperconcentration of drugs and biologics by reducing injection volume for the same dosage and enabling administration in at-home and healthcare-provider settings. The addition of Surf Bio's polymer-based hyperconcentration technology further broadens the range of biologics that can be delivered subcutaneously, meaningfully expanding the scope of opportunities across therapeutic modalities. Together, Hypercon(TM) and Surf Bio's technology complement ENHANZE(R) by enabling creation and delivery of highly concentrated biologics. The Hypercon(TM) technology has been licensed to leading biopharmaceutical partners, including Janssen, Eli Lilly, argenx, Vertex Pharmaceuticals, and Oruka Therapeutics. Halozyme also develops, manufactures and commercializes drug-device combination products using advanced auto-injector technologies designed to improve convenience, reliability and tolerability, enhancing patient comfort and adherence. The Company has two proprietary commercial products, Hylenex(R) and XYOSTED(R), partnered commercial products and ongoing development programs with Teva Pharmaceuticals and McDermott Laboratories Limited, an affiliate of Viatris Inc. Halozyme is headquartered in San Diego, CA, with offices in Ewing, NJ; Minnetonka, MN; and Boston, MA. Minnetonka is also the site of its operations facility. Forward-Looking Statements This press release may include forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts and may include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential and statements regarding future performance and growth of Halozyme's business. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans", "will be" and similar expressions. Although Halozyme believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Halozyme, that could cause actual results and developments to differ materially from those expressed in the forward-looking information and statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors. These and other factors that may result in differences are discussed in greater detail in the Company's most recently filed Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Halozyme undertakes no obligation to update or revise any forward-looking statements or any other information contained herein. Tram Bui VP, Investor Relations and Corporate Communications 609-333-7668 [email protected] SOURCE Halozyme Therapeutics, Inc.

Yahoo Finance
Aug 15th, 2026
Halozyme beats Q2 estimates by 19%, raises full-year revenue guidance to $1.87B on surging royalties

Halozyme Therapeutics reported strong second-quarter results, beating analyst expectations across key metrics. Revenue reached $481 million, surpassing estimates of $404.3 million, driven by a 50% year-over-year increase in royalty revenue from its ENHANZE platform. The company raised its full-year revenue guidance to $1.87 billion at the midpoint, up from $1.76 billion. Adjusted earnings per share guidance also increased to $8.83 at the midpoint. CEO Helen Torley attributed the outperformance to new collaboration agreements and revenue from six different drugs using the ENHANZE platform. The quarter included significant milestone payments from newly signed licensing deals. Analysts questioned management about royalty revenue acceleration, patent exclusivity impacts, and pipeline launch timing. The company projects five to seven product launches by the mid-2030s, supporting a $1 billion royalty target.

Yahoo Finance
Aug 13th, 2026
Halozyme reports 80% Q2 royalty revenue growth driven by newer subcutaneous drug launches

Halozyme reported exceptionally strong second-quarter 2026 results, driven by ENHANZE royalty revenue growth and new partnership milestones. President and CEO Dr Helen Torley highlighted ENHANZE's performance as a compounding platform engine, demonstrating repeatability, scalability, and revenue durability. The company's newer launch products — Opdivo SC, Ocrevus SC, and Rybrevant SC — showed significant momentum with 80% quarter-on-quarter growth in royalty contributions. These join established products DARZALEX SC, VYVGART Hytrulo, and Phesgo in generating revenue. Halozyme is attracting new partners and additional products from existing collaborators at an accelerating pace. The company also noted that Hypercon, positioned as a second future compounding platform engine, is already showing similar characteristics to ENHANZE whilst applying learnings from the past decade.

Yahoo Finance
Aug 11th, 2026
Halozyme lifts guidance to $1.87B after Q2 revenue beats by 19% on royalty growth

Halozyme Therapeutics reported second-quarter revenue of $481 million, up 47.7% year on year and beating analyst estimates of $404.3 million. The biopharmaceutical drug delivery company raised its full-year revenue guidance to $1.87 billion at the midpoint, 5.9% above analysts' expectations. The company's ENHANZE platform now generates royalty revenue from six different drugs, driving 50% year-over-year royalty growth. CEO Helen Torley said the platform "is attracting new partners and additional products from our current partners at a cracking pace." Adjusted earnings per share of $2.28 beat estimates by 25.5%. The company also lifted full-year adjusted EPS guidance to $8.83 at the midpoint, a 10.3% increase from prior guidance.

Yahoo Finance
Aug 11th, 2026
Halozyme shares jump 20% on strong Q2 earnings, raises full-year guidance to $1.87B

Halozyme Therapeutics saw its shares jump 18.1% after reporting strong second-quarter earnings that beat analyst expectations. The biopharmaceutical company posted adjusted earnings of $2.28 per share on revenues of $481 million, surpassing consensus estimates of $1.82 per share and $404.3 million respectively. Revenue grew 47.7% year on year, driven by royalties and milestone payments from its ENHANZE drug delivery platform. Following the strong results, Halozyme raised its full-year revenue guidance to a midpoint of $1.87 billion and increased its adjusted earnings per share forecast to a midpoint of $8.83. The shares closed at $103.06, up 20.2% from the previous close.

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