Helix

Helix

Genomics-enabled healthcare data solutions

Overview

Helix provides genomics-driven solutions for healthcare and life sciences, enabling personalized medicine at scale for health systems, public health entities, and biopharma partners. It operates a large clinical Next-Generation Sequencing lab to generate genetic data and deliver actionable insights for diagnosis, treatment, prevention, and outbreak monitoring. Its products work by sequencing DNA in its lab and translating results into integrated data and workflows that healthcare organizations can use in patient care and research. The goal is to make genomics a practical part of healthcare, helping customers lower costs, accelerate discovery, and improve patient outcomes.

About Helix

Simplify's Rating
Why Helix is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

501-1,000

Company Stage

Series C

Total Funding

$411M

Headquarters

San Mateo, California

Founded

2015

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Simplify's Take

What believers are saying

  • September 24, 2026 Databricks launch expands higher-margin data and compute revenue.
  • September 21, 2026 Precure partnership targets one million biospecimens at Mayo Clinic.
  • July 2026 AstraZeneca deal adds another top-tier pharma customer to GenoSphere.

What critics are saying

  • AstraZeneca, GSK, and Alnylam concentration exposes Helix to renewals and pricing pressure.
  • Precure's one-million-specimen program depends on Ultima hardware and flawless lab execution.
  • Health systems can internalize genomics, shrinking Helix's moat and commoditizing Exome+.

What makes Helix unique

  • Helix pairs CLIA/CAP sequencing with longitudinal EHRs across 550,000-plus GenoSphere records.
  • Databricks-powered Research Workspaces and Claude MCP shorten genomics research workflows.
  • Mayo Clinic Precure and AstraZeneca validate Helix as enterprise partner.

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Funding

Total Funding

$411M

Above

Industry Average

Funded Over

6 Rounds

Series C funding is usually for startups that are doing well and are looking for more money to fuel major growth, such as acquiring other companies, expanding into global markets, or launching new product lines. Investors typically include larger venture capital firms and private equity.
Series C Funding Comparison
Meet Average

Industry standards

$50M
$50M
Medium
$50M
Helix
$62M
SeatGeek
$100M
Oura

Benefits

Health Insurance

Parental Leave

401(k) Company Match

401(k) Retirement Plan

Unlimited Paid Time Off

Remote Work Options

Home Office Stipend

Growth & Insights and Company News

Headcount

6 month growth

↑ 0%

1 year growth

↑ 0%

2 year growth

↑ 0%
PR Newswire
Sep 24th, 2026
Helix partners with Databricks to launch research environment for 550,000 clinicogenomic records

Helix has partnered with Databricks to launch Helix Research Workspaces, a Trusted Research Environment for population-scale clinicogenomic research. The platform provides approved partners secure access to analysis tools and compute capabilities for more than 550,000 linked clinicogenomic records. Built on the Databricks Data + AI platform, Research Workspaces gives researchers access to GenoSphere clinicogenomic records, which combine genomic data with an average of over 13 years of electronic health records. The environment features population-scale genomic analysis tools, AI-assisted coding, collaborative workspaces, and integrated oversight capabilities. Helix found that researchers using Research Workspaces had lower compute costs compared to similar work on different platforms. The launch follows Helix's earlier release of Cohort Builder, which enables researchers to build targeted clinical and genomic cohorts.

Helix
Sep 24th, 2026
Your privacy is important to us.

Your privacy is important to Helix. New research environment gives approved partners secure, governed access to analysis tools and compute capabilities for more than 550,000 linked clinicogenomic records SAN MATEO, Calif., (September 24, 2026) - Helix, the leading enterprise genomics company, today announced a partnership with Databricks, the data and AI company, to launch Helix(R) Research Workspaces, a new Trusted Research Environment (TRE) for population-scale clinicogenomic research. Built natively on the Databricks Data + AI platform, the new Research Workspaces gives approved Helix research partners secure, governed access to compute, storage and analysis tools for more than 550,000 GenoSphere(TM) clinicogenomic records. GenoSphere combines Exome+(R) genomic data with an average of more than 13 years of electronic health records, enriched with medical and pharmacy claims. Population-scale genomic research often requires specialized technical expertise and substantial effort to assemble data and establish an analysis environment. These demands can limit both the pace of discovery and who can participate. The new Research Workspaces TRE brings data and analysis tools into an easy-to-use governed application so researchers can spend less time preparing infrastructure and more time testing hypotheses, interpreting results and building on existing findings. It's designed to support investigating potential targets, discovering biomarkers and characterizing patient populations using GenoSphere datasets. Key capabilities include: * Population-scale genomic analysis with a custom genomic analysis toolkit designed to support large-scale genomic research. * AI-assisted coding: A built-in coding assistant to help researchers develop and refine analysis code more efficiently. * Collaborative research workspaces: Project-based notebooks and workspaces that allow researchers to collaborate with data access controls and monitoring built in. * Integrated oversight: Real-time visibility into analysis progress and compute costs to help researchers to monitor projects within the environment. "What excites me most is the potential to bring data, compute and AI agents together to make science faster, less expensive and accessible to more people," said James Lu, M.D., Ph.D., CEO and co-founder of Helix. "With the Research Workspaces TRE, we want researchers who haven't had access to specialized bioinformatics support to ask new questions, test ideas and replicate findings. Expanding who can participate in discovery is just as important as accelerating the work itself." Helix found that researchers using Research Workspaces TRE had lower compute costs than when they performed similar work on a different platform. Furthermore, AI capabilities can cut down the total time to answer significantly, empowering teams to test additional hypotheses and examine the robustness of their research findings. "Helix is expanding access to population-scale clinicogenomic research to advance precision medicine," said Sarah Branfman, Global VP of ISV at Databricks. "With Databricks' ISV Built On program, Helix is bringing clinical and genomic data together in a governed and scalable environment, helping research partners accelerate insight, personalize care, and improve patient outcomes." The launch builds on Helix's broader investment in research and discovery with a new centralized platform with other built in applications including partner operations and more. Earlier this year, Helix launched Helix(R) Cohort Builder, which enables researchers to build targeted clinical and genomic cohorts through a graphical interface or AI-assisted natural language search. The new Trusted Research Environment builds on those capabilities for deeper population analysis. To learn more about the Helix(R) Research Workspaces, visit helix.com/company/explorer/research-workspaces About Helix: Helix is the leading enterprise genomics platform. The company transforms health systems and enables life science organizations to leverage the power of genomics across their enterprise, creating strategic value and fueling future growth. The Helix Research Network(R)- the largest precision health network in the world - accelerates genomic discoveries and translates them into real-world clinical impact. Learn more at www.helix.com. Helix Media Contact:

Genetic Engineering & Biotechnology News
Sep 21st, 2026
Precure selects Helix as multiomics lab and AI tools provider.

Precure selects Helix as multiomics lab and AI tools provider. September 21, 2026 Precure officials say they have selected Helix as its multiomic laboratory and AI tools provider supporting plans to generate molecular data from approximately one million biospecimens. The goal is to accelerate the integration of molecular insights into routine clinical care at the Mayo Clinic and across health systems more broadly. The Mayo Clinic last week launched Precure with founding partner Thermo Fisher Scientific to help transform how the life sciences community understands the biological changes that occur as disease develops before symptoms occur. Precure brings together clinical expertise, de-identified longitudinal health information, and population-scale molecular data to accelerate the development of new approaches with healthcare applications. Helix will provide both advanced AI tools for delivery of genomics into the clinic and biomarker driven research, and population scale multiomic capability that encompasses clinical whole genome sequencing (WGS) and research grade proteome sequencing. Linked with longitudinal clinical information and high performance compute infrastructure, the objective is to create new opportunities for prevention, diagnosis, and treatment, according to Aaron Mangold, MD, chief medical officer, Precure. "Our goal is to generate genomic information that can help inform patient care while creating a powerful resource for discovery," said Mangold. "We are working to make clinical whole genome sequencing and multiomics a foundation of care, helping us detect disease sooner and act earlier." Building on Mayo Clinic's Tapestry study, which utilized Helix's Exome+ sequencing technology and reached 100,000 participants, Precure is extending that collaboration by leveraging Helix's experience providing workflow orchestration, (CLIA/CAP) genomic sequencing, data infrastructure, and AI tools to its health system partners. Precure and Helix have selected Ultima Genomics' UG200(TM) Ultra Sequencing Platform as part of the program's large-scale multiomics initiative. Helix will use a fleet of Ultima's next-generation platforms to generate genomic data for WGS and read-out for proteomics at scale. "The genome is becoming an enduring patient resource, providing a precision baseline for a lifetime of care," noted James Lu, MD, PhD, CEO of Helix. "Helix brings together the laboratory and data capabilities to make this possible at scale." Helix joins Precure as a collaborator and minority owner. Mayo Clinic's involvement in Precure is intended to advance its nonprofit mission. Any financial returns to Mayo Clinic would be reinvested in its mission of patient care, research and education. Visit mayo.edu/research/precure for more information.

Newswise
Sep 21st, 2026
Precure, LLC selects Helix as multi-omics lab and AI tools provider.

Precure, LLC selects Helix as multi-omics lab and AI tools provider. Helix to generate clinical whole genome sequencing and multi-omics data from one million biospecimens, advancing precision medicine as the standard of care. Newswise - ROCHESTER, Minn. and SAN MATEO, Calif. - Precure, LLC today announced the selection of Helix as its multi-omic laboratory and AI tools provider supporting plans to generate comprehensive molecular data from approximately one million biospecimens and accelerate the integration of molecular insights into routine clinical care at Mayo Clinic and across health systems more broadly. Less than a week ago, Mayo Clinic announced the launch of Precure, LLC, with founding partner Thermo Fisher Scientific, to help transform how the life sciences community understands the biological changes that occur as disease develops before symptoms occur. Precure, LLC brings together clinical expertise, de-identified longitudinal health information and population-scale molecular data to accelerate the development of new approaches to care. Helix will provide both advanced AI tools for delivery of genomics into the clinic and biomarker driven research, and population scale multi-omic capability that encompasses clinical whole genome sequencing (WGS) and research grade proteome sequencing. Linked with longitudinal clinical information and high performance compute infrastructure, the objective is to create new opportunities for prevention, diagnosis and treatment. "Our goal is to generate genomic information that can help inform patient care while creating a powerful resource for discovery," said Aaron Mangold, M.D., chief medical officer, Precure, LLC. "We are working to make clinical whole genome sequencing and multi-omics a foundation of care, helping us detect disease sooner and act earlier." Building on prior work which utilized Helix's Exome+(R) sequencing technology, Precure, LLC extends that collaboration by leveraging Helix's experience providing workflow orchestration, (CLIA/CAP) genomic sequencing, data infrastructure, and AI tools to its health system partners. Precure, LLC and Helix have selected Ultima Genomics' UG200(TM) Ultra Sequencing Platform as part of the program's large-scale multi-omics initiative. Helix will use a fleet of Ultima's next-generation platforms to generate high-quality genomic data for WGS and read-out for proteomics at scale. "The genome is becoming an enduring patient resource, providing a precision baseline for a lifetime of care," said James Lu, M.D., Ph.D., CEO of Helix. "Helix brings together the laboratory and data capabilities to make this possible at scale." Mayo Clinic's involvement in Precure, LLC is intended to advance its nonprofit mission. Any financial returns to Mayo Clinic would be reinvested in its mission of patient care, research and education. Visit mayo.edu/research/precure for more information. About Precure, LLC Precure, LLC is a Mayo Clinic-controlled company established to generate and responsibly integrate population-scale molecular data with longitudinal clinical information. Precure, LLC creates the infrastructure and scale needed to enable external collaborations, disease-focused discovery and the development of new diagnostics, therapeutics and other healthcare solutions. It complements Mayo Clinic's investigator-led research and clinical translation activities. About Mayo Clinic Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news. About Helix Helix is an enterprise genomics company connecting clinical care and discovery. Its platform brings together clinical sequencing, integration of genomic information into healthcare, and research tools built on linked genomic and longitudinal clinical data. Through its health system partnerships, the Helix Research Network and GenoSphere, Helix helps healthcare and life sciences organizations apply genomics to patient care and the development of new diagnostics and treatments. Learn more at www.helix.com. Media contact. Type of article. Section.

San Francisco Biotechnology Network
Sep 10th, 2026
Helix launches whole exome+(r) sequencing for patients with rare and unexplained genetic conditions.

Helix launches whole exome+(r) sequencing for patients with rare and unexplained genetic conditions. For patients with unexplained developmental delay, neurological conditions, and rare genetic disease, WES+ brings exome, mitochondrial, and chromosomal analysis together in a single order SAN MATEO, Calif., Sept. 10, 2026 /PRNewswire/ - Helix, the leading enterprise genomics platform,...

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