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Janux Therapeutics develops cancer immunotherapies that activate the immune system inside tumors to attack cancer while sparing healthy tissue. Its products are tumor-activated and use a proprietary platform masking technology to reduce toxic side effects and improve efficacy compared with traditional T cell engagers. The company advances drug candidates through clinical trials, aiming for regulatory approval and eventual commercialization, with revenue expected from partnerships, licensing, and the sale of approved therapies. Its lead program JANX007 is being evaluated in a Phase 1 trial (ENGAGER PSMA 01) for metastatic prostate cancer to assess safety and preliminary effectiveness.
Industries
Biotechnology
Healthcare
Company Size
51-200
Company Stage
IPO
Headquarters
San Diego, California
Founded
2017
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$950.3M
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Janux Therapeutics reported a narrower second-quarter 2026 net loss of $21.97 million, or $0.35 per share, compared with a loss of $33.86 million, or $0.55 per share, a year earlier. The shares rose 7.1% following the announcement. For the first half of 2026, the company reduced its net loss to $46.33 million, or $0.74 per share, signalling improved cost control and operating efficiency. The biotech firm's investment case centres on its TRACTr platform and oncology pipeline, particularly clinical readouts for JANX007 and progress on JANX014. Key near-term factors include execution of its Bristol Myers Squibb collaboration. Despite the improved results, funding needs and dilution risk remain significant concerns for investors, alongside high valuation multiples and ongoing unprofitability.
Janux Therapeutics (NASDAQ:JANX) announces earnings results. August 8, 2026 Key points. * Janux Therapeutics missed quarterly expectations: The clinical-stage biotech reported a loss of $0.35 per share versus the consensus loss estimate of $0.25, while revenue of $10.27 million fell short of $19.07 million expected. * Shares remained volatile but above recent averages: JANX traded at $15.85, with a market capitalization of about $966.5 million and a 52-week range of $12.12 to $35.34. * Analyst sentiment is still cautiously positive: The stock carries a "Moderate Buy" consensus rating and an average price target of $37.58, despite UBS downgrading it to Neutral and several firms lowering their targets. * Five stocks to consider instead of Janux Therapeutics. Janux Therapeutics (NASDAQ:JANX - Get Free Report) posted its earnings results on Thursday. The company reported ($0.35) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.25) by ($0.10), FiscalAI reports. The business had revenue of $10.27 million during the quarter, compared to analysts' expectations of $19.07 million. Janux Therapeutics stock performance. Janux Therapeutics stock traded down $0.25 during midday trading on Friday, hitting $15.85. 689,025 shares of the company's stock were exchanged, compared to its average volume of 744,057. The company has a market cap of $966.53 million, a P/E ratio of -9.66 and a beta of 2.50. The stock has a 50-day moving average price of $15.04 and a two-hundred day moving average price of $14.44. Janux Therapeutics has a 52-week low of $12.12 and a 52-week high of $35.34. Insider transactions at Janux Therapeutics. In other Janux Therapeutics news, insider Janeen Noel Doyle sold 4,059 shares of Janux Therapeutics stock in a transaction that occurred on Tuesday, June 2nd. The shares were sold at an average price of $14.03, for a total transaction of $56,947.77. Following the completion of the sale, the insider directly owned 75,941 shares in the company, valued at $1,065,452.23. The trade was a 5.07% decrease in their ownership of the stock. The sale was disclosed in a document filed with the SEC, which is available through this hyperlink. The sale was made to cover tax withholding obligations related to the vesting of equity awards. Also, VP Maria Dobek sold 2,038 shares of the business's stock in a transaction that occurred on Monday, May 11th. The stock was sold at an average price of $14.17, for a total transaction of $28,878.46. Following the completion of the transaction, the vice president directly owned 32,270 shares of the company's stock, valued at approximately $457,265.90. This represents a 5.94% decrease in their position. Additional details regarding this sale are available in the official SEC disclosure. Company insiders own 7.90% of the company's stock. Institutional inflows and outflows. Institutional investors have recently added to or reduced their stakes in the company. State Street Corp raised its stake in shares of Janux Therapeutics by 103.8% during the fourth quarter. State Street Corp now owns 3,853,951 shares of the company's stock worth $53,185,000 after acquiring an additional 1,962,486 shares in the last quarter. Prosight Management LP boosted its stake in shares of Janux Therapeutics by 176.5% in the 4th quarter. Prosight Management LP now owns 2,392,523 shares of the company's stock valued at $33,017,000 after purchasing an additional 1,527,173 shares in the last quarter. Wellington Management Group LLP grew its holdings in shares of Janux Therapeutics by 129.5% during the 4th quarter. Wellington Management Group LLP now owns 1,610,186 shares of the company's stock valued at $22,221,000 after purchasing an additional 908,582 shares during the last quarter. Balyasny Asset Management L.P. bought a new position in shares of Janux Therapeutics during the 4th quarter valued at $12,221,000. Finally, Alyeska Investment Group L.P. raised its position in Janux Therapeutics by 206.3% in the 4th quarter. Alyeska Investment Group L.P. now owns 1,301,089 shares of the company's stock worth $17,955,000 after purchasing an additional 876,244 shares during the period. Institutional investors own 75.39% of the company's stock. Analyst ratings changes. JANX has been the subject of several recent research reports. UBS Group cut Janux Therapeutics from a "buy" rating to a "neutral" rating and reduced their price target for the company from $57.00 to $15.00 in a research report on Wednesday, April 15th. Guggenheim cut their target price on Janux Therapeutics from $58.00 to $55.00 and set a "buy" rating for the company in a research note on Friday. Stifel Nicolaus set a $35.00 target price on Janux Therapeutics in a report on Friday. JonesTrading decreased their price target on Janux Therapeutics from $50.00 to $28.00 and set a "buy" rating on the stock in a research report on Tuesday, April 28th. Finally, Wedbush cut their price objective on shares of Janux Therapeutics from $45.00 to $36.00 and set an "outperform" rating for the company in a research report on Friday, May 8th. Nine investment analysts have rated the stock with a Buy rating, three have given a Hold rating and two have issued a Sell rating to the company's stock. According to MarketBeat, Janux Therapeutics presently has a consensus rating of "Moderate Buy" and an average target price of $37.58. Discover more Company Earnings Stock Average Calculator Financial News Subscription About Janux Therapeutics. Janux Therapeutics is a clinical-stage biotechnology company focused on developing next-generation intratumoral immuno-oncology therapies that harness the body's innate and adaptive immune systems. The company designs and synthesizes proprietary Toll-like receptor (TLR) agonists to reprogram the tumor microenvironment. Janux is publicly traded on the Nasdaq under the symbol JANX. Its lead programs include JTX-8064, a fully synthetic TLR4 agonist engineered for optimal stability and potency, and JTX-4014, a TLR1/2 agonist formulated for direct intratumoral administration. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Janux Therapeutics, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Janux Therapeutics wasn't on the list. While Janux Therapeutics currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys. The AI boom is creating opportunities across semiconductors, cloud computing, enterprise software, infrastructure, cybersecurity, and automation. Inside this report, you'll find 10 companies positioned to benefit as artificial intelligence moves from hype to real-world deployment and becomes a core growth driver for corporate America.
Janux Therapeutics, Inc. (NASDAQ:JANX), a clinical-stage biopharmaceutical company developing tumour-activated immunotherapies, received a Buy rating from Truist Securities on 25 June with a $26 price target. The firm highlighted JANX007's need for improved tolerability whilst noting the programme validates Janux's TRACTr platform. Truist identified growth potential from pipeline candidates including JANX014, JANX013 and JANX011 across oncology and autoimmune conditions. On 23 June, the company disclosed that Chief Medical Officer William Go had departed, classified as termination without cause. Janux stated current clinical leadership would assume his responsibilities temporarily, emphasising the transition would not impact development strategy, regulatory objectives or clinical timelines. The company is searching for a replacement.
Janux Therapeutics reported first quarter 2026 financial results, with cash and cash equivalents and short-term investments totalling $956.4 million as of 31 March 2026. The clinical-stage biopharmaceutical company posted a net loss of $24.4 million for the quarter. The company is advancing its prostate cancer franchise with JANX007 enrolling in Phase 1b trials and JANX014 initiating clinical evaluation. Janux has discontinued development of JANX008 following Phase 1a completion to prioritise other pipeline opportunities. The company plans to initiate clinical development of JANX013 in the second half of 2026. Janux received a $35 million milestone payment from Bristol Myers Squibb following development candidate nomination under their collaboration agreement. The company appointed William Go as Chief Medical Officer to support clinical advancement.
Janux Therapeutics, a clinical-stage biopharmaceutical company, has appointed William Go as Chief Medical Officer, effective 26 January 2026. Dr Go succeeds Zachariah McIver, who is leaving to pursue other opportunities. Dr Go brings over 20 years of haematology and oncology experience, having led programmes from early development through regulatory approvals and launches. Most recently, he served as Chief Medical Officer at A2 Biotherapeutics, where he initiated three Phase 1 clinical trials. Previously at Kite Pharma, he led the pivotal ZUMA-1 trial supporting FDA and EMA approvals of YESCARTA, the first CAR T-cell therapy approved for large B-cell lymphoma. Janux is advancing a pipeline of immunotherapies including two clinical-stage candidates targeting PSMA and EGFR for various cancers.
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Industries
Biotechnology
Healthcare
Company Size
51-200
Company Stage
IPO
Headquarters
San Diego, California
Founded
2017
Find jobs on Simplify and start your career today