Metagenomi

Metagenomi

Develops genome-editing tools for genetic therapies

Overview

Metagenomi develops genome editing tools and genetic medicines by tapping natural environmental genomes. It sources genetic material from diverse ecosystems (metagenomics), sequences it, and engineers promising proteins into genome editing tools. The tools are designed to be efficient, specific, and targetable, and are advanced using artificial intelligence and high-throughput screening to sift billions of proteins quickly. The main revenue pathway is likely the sale of approved genetic medicines to healthcare providers and patients. The key differentiator is leveraging naturally evolved proteins discovered from unexplored environments, combined with AI-assisted discovery and rapid screening to identify strong genome editors. The company’s goal is to create potentially curative therapeutics for a range of diseases through gene editing.

About Metagenomi

Simplify's Rating
Why Metagenomi is rated
C+
Rated B on Competitive Edge
Rated C on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

AI & Machine Learning

Biotechnology

Healthcare

Company Size

51-200

Company Stage

IPO

Headquarters

Emeryville, California

Founded

2016

Simplify Jobs

Simplify's Take

What believers are saying

  • MGX-001 sustains Factor VIII activity over 16 months in nonhuman primates.
  • $248.3 million cash runway funds operations through 2027.
  • Four Ionis targets reach lead optimization for 2025 development candidates.

What critics are saying

  • Class action lawsuits over Moderna collaboration termination drop stock from $15 to $6.17.
  • Prime Medicine's prime editing outpaces MG119-28 in precision for hemophilia.
  • Clinical delays in MGX-001 IND exhaust cash by 2027, forcing dilution.

What makes Metagenomi unique

  • Metagenomi sources novel editing systems via metagenomics from unexplored environments.
  • MG119-28 compact CRISPR nuclease achieves 64% Atxn2 knockdown in mice via AAV.
  • Largest wholly-owned toolbox of over 20,000 diverse gene editing systems.

Help us improve and share your feedback! Did you find this helpful?

Funding

Total Funding

$470.1M

Above

Industry Average

Funded Over

6 Rounds

IPO funding comparison data is currently unavailable. We're working to provide this information soon!
IPO Funding Comparison
Coming Soon

Benefits

Health Insurance

401(k) Retirement Plan

401(k) Company Match

Performance Bonus

Stock Options

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

3%

2 year growth

3%
GlobeNewswire
Feb 23rd, 2026
Metagenomi Therapeutics, Inc. to Present at the 46th Annual TD Cowen Healthcare Conference

Metagenomi Therapeutics, Inc. to present at the 46th Annual TD Cowen Healthcare Conference. EMERYVILLE, Calif., Feb. 23, 2026 (GLOBE NEWSWIRE) - Metagenomi Therapeutics, Inc. (Nasdaq: MGX) (the "Company"), an in vivo genome editing company capitalizing on its proprietary technologies to create curative genetic medicines for patients, today announced that Jian Irish, Ph.D., M.B.A., President and Chief Executive Officer of the Company, will participate in a fireside chat at the 46th Annual TD Cowen Healthcare Conference, being held in Boston, MA, on Monday, March 2, 2026 at 11:10 a.m. ET. The fireside chat presentation will be made available on the "News & Events" page in the Investors section of the Company's website at https://ir.metagenomi.co/news-events/events. About Metagenomi Therapeutics, Inc. Metagenomi Therapeutics, Inc. is an in vivo genome editing company capitalizing on its proprietary technologies to create curative genetic medicines for patients. The Company was founded on the science of metagenomics, the study of genetic materials recovered from the natural environment, to discover and develop a suite of novel editing tools potentially capable of correcting any type of genetic mutation found anywhere in the human genome. The Company focuses on high value programs in disease indications with well-understood biology and clearly defined clinical development and regulatory pathways. Going forward, the Company intends to continue to expand its pipeline by leveraging its proprietary genetic editing capabilities in site specific deletion, integration and correction. MGX-001, the Company's lead, wholly-owned development program in hemophilia A, has demonstrated a preclinical profile potentially competitive with best-in-class treatment options, including targeted genome editing and durable gene expression in a one-time treatment. MGX-001 is designed to provide curative, life-long protection from bleeding events and joint damage in adults and children with hemophilia A. The Company is also currently pursuing other secreted protein deficiencies leveraging the MGX-001 site-specific genome integration system and partnered assets targeting cardiometabolic diseases. For more information, please visit https://metagenomi.co. Cautionary Note Regarding Forward-Looking Statements This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements, which are often indicated by terms such as "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to," "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions include, but are not limited to, any statements relating to our product development programs, including the timing of and our ability to conduct IND-enabling studies and make regulatory filings such as INDs, expectations regarding MGX-001, including the preclinical profile being potentially competitive with best-in-class treatment options and timing to submit the IND/CTA package, statements regarding the Company's plans to prioritize its preclinical pipeline and potential for value creation and sustainable growth, statements regarding upcoming milestones including the nomination of development candidates, statements concerning the potential of therapies and product candidates, statements concerning the impact of the organizational restructuring, statements concerning our anticipated cash runway, and any other statements that are not historical facts. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of IND submissions and starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation and the current regulatory environment; patent and intellectual property matters; competition; the volatility of capital markets and other adverse macroeconomic factors; as well as other risks described in "Risk Factors," in our most recent Form 10-K and other risk factors set forth from time to time in our filings with the Securities and Exchange Commission made pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Investor Contacts:

Stockhouse
May 14th, 2025
Metagenomi Presents Data Highlighting Advancements in Next-Generation Genome Editing Technologies at ASGCT Annual Meeting 2025

EMERYVILLE, Calif., May 14, 2025 (GLOBE NEWSWIRE) - Metagenomi, Inc. (Nasdaq: MGX), a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today announced the presentation of three abstracts at the American Society of Gene & Cell Therapy (ASGCT) 28th Annual Meeting, taking place from May 13 - 17, 2025, in New Orleans, Louisiana.

BioSpace
Mar 18th, 2025
Metagenomi Reports Business Updates And Full Year 2024 Financial Results

Hemophilia A presentation at American Society of Hematology (ASH) 66th Annual Meeting demonstrated sustained Factor VIII (FVIII) activity in nonhuman primate (NHP) study for more than 16 months Leveraged hemophilia A albumin platform to achieve in vivo proof-of-concept in multiple secreted protein deficiencies to support wholly-owned follow-on program Progressed four Wave 1 Ionis targets to lead optimization with plans to declare one to two development candidates (DCs) in 2025 Well capitalized with $248.3 million in cash, cash equivalents and available-for-sale marketable securities at the end of Q4 2024; Cash runway anticipated to support operating plans into 2027 EMERYVILLE, Calif., March 17, 2025 (GLOBE NEWSWIRE) -- Metagenomi, Inc. (Nasdaq: MGX), a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today reported financial results for the full year ended December 31, 2024, and provided business updates. “Our diverse and modular AI-driven metagenomics platform is designed to precisely target any site in the human genome, yielding the potential to address the full spectrum of genetic diseases,” said Brian C. Thomas, PhD, CEO and founder of Metagenomi. “In 2024, we made significant progress toward our goal of developing curative genetic medicines for patients. We progressed MGX-001, our potentially transformative treatment for hemophilia A, and leveraged the MGX-001 platform to advance an additional wholly-owned program for an undisclosed secreted protein deficiency disorder

Stock Titan
Jan 8th, 2025
Metagenomi to Present at the 43rd Annual J.P. Morgan Healthcare Conference

Metagenomi (Nasdaq: MGX), a precision genetic medicines company, has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference.

GlobeNewswire
Nov 6th, 2024
METAGENOMI ALERT: Bragar Eagel & Squire, P.C. Reminds Investors that a Class Action Lawsuit Has Been Filed Against Metagenomi, Inc. and Encourages Investors to Contact the Firm

METAGENOMI ALERT: Bragar Eagel & Squire, P.C. Reminds investors that a class action lawsuit has been filed against Metagenomi, Inc. and encourages investors to contact the firm.

Recently Posted Jobs

Sign up to get curated job recommendations

There are no jobs for Metagenomi right now.

Find jobs on Simplify and start your career today

We update Metagenomi's jobs every few hours, so check again soon! Browse all jobs →