Nuclera

Nuclera

On-demand gene-to-protein synthesis platform

Overview

Nuclera provides on-demand gene and protein synthesis for researchers in synthetic biology, enabling writing of genes and proteins directly in benchtop laboratories. Its platform translates genetic designs into physical DNA and expressed proteins quickly, often within a day, by selling a benchtop synthesis platform and related consumables to labs and institutions. The workflow lets users design sequences and order synthesis or run gene-to-protein construction with high speed, flexibility, and accuracy. Nuclera aims to democratize biology by making gene and protein writing accessible and customizable, so researchers can design, build, and engineer biology in their own labs.

About Nuclera

Simplify's Rating
Why Nuclera is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Industrial & Manufacturing

Biotechnology

Healthcare

Company Size

51-200

Company Stage

Series C

Total Funding

$224.9M

Headquarters

Cambridge, United Kingdom

Founded

2013

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Simplify's Take

What believers are saying

  • January 2026 Series C reached $87 million, extending runway for commercialization.
  • May 2026 antibody triage service targets AI-discovery bottlenecks with 96-plex screening.
  • September 2026 CEO Carl Raimond brings Thermo Fisher and Olink scaling experience.

What critics are saying

  • Thermo Fisher and Cytiva can outspend Nuclera across protein discovery workflows.
  • May 2026 antibody service and 2026 membrane launches still need repeatable customer adoption.
  • If consumables and services stall, Nuclera remains a capital-intensive hardware company.

What makes Nuclera unique

  • Nuclera's eProtein Discovery combines cell-free synthesis and digital microfluidics for benchtop workflows.
  • March 2026 GPCR nanodisc panel delivers active membrane proteins in 48 hours.
  • February 2026 leadXpro partnership links AI construct design with experimental screening.

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Funding

Total Funding

$224.9M

Above

Industry Average

Funded Over

10 Rounds

Series C funding is usually for startups that are doing well and are looking for more money to fuel major growth, such as acquiring other companies, expanding into global markets, or launching new product lines. Investors typically include larger venture capital firms and private equity.
Series C Funding Comparison
Below Average

Industry standards

$50M
$12M
Nuclera
$40M
Figma
$50M
Medium
$62M
SeatGeek
$100M
Oura

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

401(k) Retirement Plan

Paid Holidays

Professional Development Budget

Stock Options

Company Social Events

Growth & Insights and Company News

Headcount

6 month growth

↑ 0%

1 year growth

↑ 4%

2 year growth

↑ 2%
Zyme Communications
Sep 22nd, 2026
Nuclera appoints Carl Raimond as Chief Executive Officer.

Nuclera appoints Carl Raimond as Chief Executive Officer. * Former Olink Proteomics President brings extensive life-science tools leadership experience, having helped lead Olink through its $3.1 billion acquisition by Thermo Fisher Scientific * Co-founder and former CEO Dr Michael Chen transitions to Chief Scientific and Business Officer Cambridge, UK, and Boston, MA, USA, 22 September 2026: Nuclera, the biotechnology company enabling access to innovative protein technologies, today announced the appointment of Carl Raimond as Chief Executive Officer, effective immediately. Dr Michael Chen, Nuclera's co-founder and former CEO, transitions to the role of Chief Scientific and Business Officer, continuing to provide scientific leadership while supporting market development and strategic partnerships. The leadership transition marks the next phase in Nuclera's evolution as the Company builds on more than a decade of expertise in cell-free protein synthesis, digital microfluidics and protein production. The combination of Carl's experience scaling life-science businesses with Michael's scientific leadership and deep understanding of Nuclera's technology and markets will support the Company as it expands adoption of its platform across priority life-science workflows. Nuclera is applying its cell-free protein synthesis and digital microfluidics capabilities to accelerate the speed of protein science, with current focus areas including full-length IgG antibody screening, challenging membrane protein synthesis, and soluble protein expression. In May 2026, the Company launched antibody service capabilities to support early experimental triage for antibody discovery programs, complementing its eProtein Discovery(TM) system for in-house protein expression and screening. The Company is also extending its antibody strategy beyond centralized service delivery. Nuclera is advancing early partner work toward customer-site antibody screening workflows, designed to bring cell-free expression and binding triage closer to AI-enabled discovery teams and reduce the delay between computational design and experimental evidence. Carl joins Nuclera from Thermo Fisher Scientific, where he served as President of Proteomic Sciences following its acquisition of Olink Proteomics. He previously served as President of Olink Proteomics, helping lead the company through its $3.1 billion acquisition by Thermo Fisher Scientific in 2023. An experienced life-sciences executive, Carl has also held senior leadership roles at PerkinElmer, Agilent Technologies and Affymetrix. As Chief Scientific and Business Officer, Michael will focus on scientific strategy, market development and strategic partnerships, working closely with Carl as the Company enters its next phase of growth whilst maintaining continuity in Nuclera's scientific direction. Carl Raimond, CEO at Nuclera, said: "Nuclera has built a differentiated technology platform at the intersection of cell-free protein synthesis, digital microfluidics, and protein discovery. I'm excited to join the Company as we sharpen our focus on customer adoption, commercial execution, and expanding applications of our technology across life-science workflows. Michael's scientific leadership remains central to Nuclera's future, and I look forward to working with him and the team to translate this strong technology foundation into impactful solutions for our customers." Dr Michael Chen, co-founder and Chief Scientific and Business Officer at Nuclera, commented: "As a structural biologist, I know firsthand the time and frustration protein production can cost a development program. That frustration is part of why we started Nuclera. I'm incredibly proud of what the team has built and the difference our technology is already making for protein scientists. Now, we've reached an important point in the Company's evolution, and Carl is the right CEO to lead us forward. Carl's experience building and scaling life-science businesses, combined with his understanding of the opportunity ahead, will be a huge asset to Nuclera. I'm excited to work alongside him to bring that impact to every benchtop."

Bio-IT World
May 10th, 2026
Nuclera launches antibody triage service to advance AI-driven antibody discovery.

Nuclera launches antibody triage service to advance AI-driven antibody discovery. May 10, 2026 Rapid binder triage, of AI-driven candidate sets, enables early elimination of non-binders ahead of costly downstream workflows Powered by cell-free technology to convert AI-generated candidates into experimental binding data Cambridge, UK and Boston MA, USA 11 May 2026: Nuclera, the biotechnology company enabling rapid access to high-quality proteins, today announced the launch of its antibody screening service to streamline the transition from antibody hit generation to lead selection. The service will support researchers seeking to identify the most promising antibody candidates to progress to costly mammalian expression and functional testing, addressing a key bottleneck in AI-driven antibody discovery. The launch follows the Company's Series C extension[1], enabling the integration of antibody expression and binding validation to support antibody discovery workflows. Nuclera's antibody service delivers a rapid upstream triage workflow that identifies viable binders early on in the process between in silico hit generation and mammalian scale-up. By utilizing 96-plex binary cell-free expression and binding assays, the service screens full length antibody libraries in parallel, rapidly narrowing large candidate sets to a focused subset of confirmed binders. Surface Plasmon Resonance is then performed on prioritized hits for binding kinetics. Despite advances in bioinformatics and in silico antibody design, a major bottleneck remains in experimentally validating large numbers of candidates. Traditional antibody secondary screening methods are often slow and fragmented, which typically result in large amounts of resources being spent on non-binders through costly processes. As AI-driven approaches generate increasingly large antibody libraries, the need for rapid, cost-effective triage solutions has become more critical. Nuclera's antibody service addresses this gap by converting large AI-generated libraries into experimental binding data and enabling early elimination of non-binders, reserving expensive downstream biology for candidates proven to bind and accelerating progression to validated leads. Dr Michael Chen, CEO and co-founder, Nuclera, said: "Antibodies are one of the most important classes of therapeutic molecules, yet antibody discovery remains inefficient, with many initially promising candidates failing during downstream validation. A key bottleneck is the cost of recombinant antibody expression and binding validation, which limits the generation of high-quality data, and is holding back the full potential of AI/ML discovery. The launch of our antibody service addresses this challenge by enabling rapid triage of large candidate sets and delivering decision-grade binding data early in the discovery process at a competitive cost. By helping teams focus on the most promising candidates before scale-up, we are taking an important step toward enabling more effective use of AI in antibody discovery." Media contact: Dr Ben Rutter Zyme Communications Tel: +44(0)7920 770 935

Yahoo Finance
Mar 30th, 2026
Nuclera launches GPCR nanodisc panel producing active proteins in 48 hours

Nuclera has launched a nanodisc panel to accelerate G-Protein Coupled Receptor (GPCR) production, enabling expression of active GPCRs in 48 hours. The panel includes a GPCR screen kit and scale-up reagents featuring eight nanodisc combinations with two membrane scaffold proteins and four lipid compositions. The technology addresses a critical bottleneck in drug discovery, as obtaining purified, stable, functional GPCRs remains challenging despite one-third of FDA-approved drugs targeting these receptors. Traditional detergent-based methods often cause proteins to adopt non-native conformations, whilst Nuclera's nanodiscs provide a soluble membrane bilayer that better maintains structural integrity. The panel integrates with Nuclera's eProtein Discovery cell-free protein synthesis platform, enabling co-translational insertion for higher yields of soluble, active membrane protein. The company launched its membrane protein workflow in 2025.

Cambridge Network
Mar 30th, 2026
Nuclera launches gpcr-focused nanodisc panel to streamline membrane protein production.

Nuclera launches gpcr-focused nanodisc panel to streamline membrane protein production. * Enables expression of active GPCRs in 48 hours * Panel supports screening to scale-up on eProtein Discovery Cambridge, UK, and Boston MA, USA, 30 March 2026: Nuclera, the biotechnology company enabling rapid access to high-quality proteins, today announced the launch of its nanodisc panel to support screening and scale-up of G-Protein Coupled Receptors (GPCRs). Building on the eProtein Discovery(TM) membrane protein workflow capabilities[1], the nanodisc panel allows membrane protein scientists focusing on GPCR research to identify optimal membrane environments and increase production of challenging therapeutic targets, GPCRs, producing active proteins in 48 hours. Nuclera's nanodisc panel includes a GPCR screen kit and scale-up reagents, including 8 nanodisc combinations, comprised of 2 membrane scaffold proteins (MSPs), and 4 lipid compositions. Allowing researchers to rapidly and cost-effectively express active GPCRs, the nanodisc panel minimizes variability associated with traditional approaches to membrane protein production. The preassembled nanodiscs target the specific charge, fluidity and/or cholesterol requirements for GPCR activity and yield. Despite one third of FDA-approved drugs acting on GPCRs[2], obtaining purified, stable, functional GPCRs remains a critical bottleneck in pharmacology and drug discovery. Traditionally, cell-based detergent micelles are used to solubilize membrane proteins, but often lead to proteins adopting non-native conformations. Nanodiscs provide a soluble membrane bilayer allowing the study of membrane proteins and their interactions under native-like conditions better maintaining structural integrity and in vivo functionality compared to detergent-based approaches. Integrating Nuclera's pre-assembled nanodiscs directly into eProtein Discovery's cell-free protein synthesis (CFPS) approach enables co-translational insertion of the nascent protein. This delivers high yields of soluble, active membrane protein with improved stability for downstream applications and streamlines drug discovery workflows from screening to characterization. Dr Audrey Dubourg, Product Manager, Nuclera, said: "Since releasing our membrane protein workflow in 2025, we have identified a huge potential in the market to support GPCR protein scientists. Our eProtein Discovery(TM) nanodisc panel empowers researchers to explore physiologically relevant environments validated for solubility, insertion and stabilization of membrane proteins. Compared to traditional approaches, these are capable of increasing protein yield whilst maintaining functionality, creating a fast-track route to purified, active GPCRs." Dr Michael Chen, CEO and co-founder, Nuclera, commented: "The release of our GPCR nanodisc panel addresses the pressure scientists face to rapidly produce functional membrane proteins. Integrated with eProtein Discovery, this capability equips researchers with a powerful approach to increase success rates in expressing active GPCRs."

Cambridge Innovation Capital
Mar 29th, 2026
Nuclera and TRIMTECH Therapeutics success at the One Nucleus Awards 2026.

Nuclera and TRIMTECH Therapeutics success at the One Nucleus Awards 2026. 29 Mar 2026 Many congratulations to all of the winners and finalists, including portfolio compnaies Nuclera and TRIMTECH Therapeutics The winners of the One Nucleus Awards 2026 were announced at an awards ceremony in London on 29 March. The One Nucleus Award categories are structured to reflect that breadth of R&D, investment, service provision and enabling support across the stakeholders. Best Therapeutic R&D Programme of the Year | Winner: Resolution Therapeutics | Finalists: Serenatis Bio, TRIMTECH Therapeutics Best Use of Emerging Technology of the Year | Winner: Nuclera | Finalists: Ignota Labs, Constructive Bio

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