Nurix Therapeutics

Nurix Therapeutics

Drug discovery targeting ubiquitin E3 ligases

Overview

Nurix Therapeutics develops drugs that use the body's own protein-degradation system to treat diseases. Its core approach is to control ubiquitin E3 ligases, enzymes that tag unwanted proteins for breakdown in cells. By modulating these ligases, Nurix aims to create therapeutics, especially small-molecule immuno-oncology agents, that can selectively remove disease-related proteins in cancer and other serious conditions. The company operates by discovering and developing drug candidates and earning revenue through partnerships, licensing, and potential future sales of its medicines. Unlike many biotech firms that target single proteins, Nurix focuses on the protein-degradation pathway to influence multiple disease processes through carefully designed molecules. The goal is to bring new cancer treatments and other therapies to patients by advancing its degrader-based drugs through research, collaboration, and development toward commercial use.

About Nurix Therapeutics

Simplify's Rating
Why Nurix Therapeutics is rated
B
Rated A on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

201-500

Company Stage

IPO

Headquarters

San Francisco, California

Founded

2012

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Simplify's Take

What believers are saying

  • Phase 3 trial for bexobrutideg in relapsed/refractory CLL planned for H1 2026 accelerates full approval and market entry.
  • Bexobrutideg's $2.3B total deal value with Roche provides substantial milestones if pivotal trials confirm efficacy and safety.
  • Expansion into immunology via new tablet formulation enables market entry in 2026, diversifying revenue beyond oncology.

What critics are saying

  • Phase 3 head-to-head trial against Pirtobrutinib could fail due to unexpected resistance, erasing $2.3B milestone value.
  • U.S. co-commercialization with Roche may cause operational conflicts, delaying rollout if Roche prioritizes its own BTK inhibitors.
  • NX-1607 Phase 1 failure due to poor T-cell activation or safety signals could invalidate immuno-oncology platform.

What makes Nurix Therapeutics unique

  • Nurix uniquely targets BTK via protein degradation, eliminating both kinase and scaffolding functions to overcome resistance.
  • Its brain-penetrant bexobrutideg enables treatment of CNS-involved B-cell malignancies and neurology indications like multiple sclerosis.
  • Unparalleled E3 ligase expertise and AI-integrated discovery engine allow rapid development of degraders across diverse protein classes.
  • Bexobrutideg demonstrated 83% ORR and 22.1-month PFS in heavily pretreated CLL patients with BTK resistance mutations.
  • The company secured a $700M upfront payment from Roche, reducing dilution risk and funding pipeline development significantly.

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Funding

Total Funding

$759.1M

Above

Industry Average

Funded Over

7 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison
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Benefits

Company Equity

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

0%

2 year growth

0%
Nurix Therapeutics
May 12th, 2026
Press releases.

Press releases. Nurix Therapeutics announces bexobrutideg oral presentation at the 2026 European Hematology Association Congress. May 12, 2026 BRISBANE, Calif., May 12, 2026 (GLOBE NEWSWIRE) - Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines, today announced that an abstract highlighting updated efficacy and safety data from the ongoing Phase 1a/b trial of BTK degrader bexobrutideg (NX-5948) in patients with chronic lymphocytic leukemia (CLL) across lines of therapy has been accepted for oral presentation at the 31st Congress of the European Hematology Association (EHA2026), taking place June 11-14, 2026, in Stockholm, Sweden. Oral Presentation Details: Title: Updated efficacy and safety data from an ongoing phase 1a/b trial of the BTK degrader bexobrutideg (NX-5948) in patients with CLL across lines of therapy Presenter: Tahla Munir, MBChB, Ph.D. Session title: s449 Novel therapies in relapsed/refractory CLL Session date and time: June 14, 2026, 11:00 - 12:15 CEST Session Room: A10-11 Hall Abstract ID: S150 About Bexobrutideg (NX-5948) Bexobrutideg is an investigational, orally bioavailable, brain penetrant, highly selective small molecule degrader of Bruton's tyrosine kinase (BTK) currently being evaluated in the DAYBreak CLL-201 clinical trial (NCT07221500), a pivotal single-arm Phase 2 study of bexobrutideg in patients with relapsed or refractory CLL. Nurix also continues enrollment in the NX-5948-301 Phase 1a/1b clinical trial (NCT05131022) of bexobrutideg in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trials can be accessed at clinicaltrials.gov. About Nurix Therapeutics, Inc. Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and autoimmune diseases. Nurix's wholly owned, clinical stage pipeline includes degraders of Bruton's tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), an E3 ligase that regulates activation of multiple immune cell types including T cells and NK cells. Nurix also is advancing multiple potentially first-in-class or best-in-class degraders and degrader antibody conjugates (DACs) in its preclinical pipeline. Nurix's partnered drug discovery pipeline consists of a preclinical stage degrader of STAT6, SAR448272/NX-3911, in collaboration with Sanofi, a clinical stage degrader of IRAK4, GS6791, in collaboration with Gilead, as well as multiple additional programs under collaboration agreements with Gilead Sciences, Inc., Sanofi S.A. and Pfizer Inc., within which Nurix retains certain options for co-development, co-commercialization and profit sharing in the United States for multiple drug candidates. Powered by an AI-integrated discovery engine capable of tackling virtually any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Nurix is headquartered in Brisbane, California. For additional information visit http://www.nurixtx.com.

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