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Pacira BioSciences

Non-opioid pain management pharmaceuticals and devices

Overview

Pacira BioSciences focuses on non-opioid pain management and regenerative health. Its products include EXPAREL, a local analgesic that is a bupivacaine liposome injectable suspension given at surgery to provide extended pain relief at the surgical site, and iovera, a handheld device that uses cryoanalgesia to temporarily block pain signals from peripheral nerves. The company generates revenue by selling these products to hospitals, ambulatory surgery centers, and physicians in the United States. Unlike many pain-management players that rely on opioids or single offerings, Pacira combines a pharmaceutical product (EXPAREL) with a medical device (iovera) to address postsurgical pain and is expanding into new indications and geographic markets while developing additional pain-management and regenerative health solutions. Its goal is to broaden use of its current therapies and create new products to meet unmet needs in pain management and regenerative health.

Significant Headcount GrowthFunded Recently

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About Pacira BioSciences

Simplify's Rating
Why Pacira BioSciences is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

501-1,000

Company Stage

IPO

Headquarters

Brisbane, California

Founded

1989

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Simplify's Take

What believers are saying

  • UnitedHealthcare expanded separate EXPAREL reimbursement in 2026, covering over 150 million lives.
  • PCRX-201 showed two-year durability in 2026 Phase 1 data, supporting a 2027 pipeline readout.
  • LG Chem filed for EXPAREL in South Korea in 2026, creating 2027 international revenue potential.

What critics are saying

  • Fresenius gains volume-limited generic EXPAREL entry in early 2030, then unlimited entry in 2039.
  • Pacira sold iovera° to Zimmer Biomet in 2026, shrinking recurring revenue and headcount.
  • EXPAREL remains concentrated in one product, so a reimbursement or patent setback hits valuation fast.

What makes Pacira BioSciences unique

  • EXPAREL still anchors Pacira's non-opioid franchise, with 2026 sales of $600-$620 million guided.
  • Pacira's 21 Orange Book patents and reissued '495 patent extend EXPAREL protection into 2044.
  • J&J MedTech co-promotes ZILRETTA, expanding Pacira's physician reach beyond orthopedics since July 2025.

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Funding

Total Funding

$662.5M

Above

Industry Average

Funded Over

5 Rounds

Acquisition funding comparison data is currently unavailable. We're working to provide this information soon!
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Stock Price

Growth & Insights and Company News

Headcount

6 month growth

5%

1 year growth

5%

2 year growth

3%
South Jordan Journal
Oct 8th, 2026
Viatris Agrees to Acquire Pacira BioSciences, Advancing Its Innovative Medicines Strategy and Becoming a Leader in Non-Opioid Pain Therapies

The South Jordan Journal is the local newspaper covering news and events in the City of South Jordan, Utah. The South Jordan Journal provides one of the best advertising channels to the residents of the City of South Jordan.

Pharmaceutical Technology
Oct 6th, 2026
Pacira partners with Molteni for Exparel commercialisation.

Pacira partners with Molteni for Exparel commercialisation. The companies expect the first commercial sale under the partnership to occur in 2027. Pacira BioSciences has entered into an exclusive agreement with Italian pharmaceutical company Molteni Farmaceutici to distribute and commercialise Exparel across the EU and the UK. Exparel (bupivacaine liposome injectable suspension), is a long-acting local analgesic used for postsurgical pain management. Under the agreement, Pacira will obtain an undisclosed upfront payment, alongside a supply price and royalties generated from future commercial sales across the licensed territories. Pacira will be responsible for manufacturing the therapy. Molteni Farmaceutici will manage regulatory procedures, market access, and commercialisation efforts in the designated markets. Molteni Farmaceutici plans a phased commercial rollout of the analgesic, starting in Austria, Germany, Italy, and Poland, while also seeking regulatory approval in Switzerland. The companies expect the first commercial sale under the partnership to occur in 2027. Locust Walk served as the exclusive financial advisor to Pacira for the transaction. Pacira BioSciences CEO Frank Lee said: "Pharmaceutical Technology is excited to announce another strategic partnership that advances its 5x30 growth strategy and reinforces its commitment to expanding patient access to best-practice opioid-sparing postsurgical pain management. "With Molteni Farmaceutici's longstanding leadership in pain management and extensive distribution network across Europe, they are ideally positioned to unlock EXPAREL's full potential in key European markets." Molteni Farmaceutici focuses on specialty healthcare, operating in the fields of hospital-based treatments, oncology supportive care, and pain management. Alongside Exparel, Pacira's commercial portfolio includes Zilretta (triamcinolone acetonide extended-release injectable suspension), an intra-articular extended-release injection indicated for managing osteoarthritis knee pain. The company is also developing a pipeline of clinical-stage candidates for musculoskeletal pain and related conditions. Its investigational product, PCRX-201 (enekinragene inzadenovec), is a locally administered gene therapy currently undergoing Phase II clinical development for knee osteoarthritis. In November 2025, AmacaThera entered into an exclusive worldwide licensing agreement with Pacira BioSciences for up to $230m for AMT-143, an investigational long-acting non-opioid anaesthetic. Give your business an edge with its leading industry insights.

Newswise
Sep 14th, 2026
ASA and Pacira BioSciences strengthen strategic collaboration focused on education, quality improvement and patient outcomes.

ASA and Pacira BioSciences strengthen strategic collaboration focused on education, quality improvement and patient outcomes. Newswise - CHICAGO - The American Society of Anesthesiologists (ASA) today announced the continued expansion of its collaboration with Pacira BioSciences, Inc. through ASA's Corporate Supporter Program. Building on three years of engagement, ASA and Pacira are working to advance shared priorities in physician education, advocacy, quality improvement and evidence-based non-opioid approaches to pain management that support improved patient outcomes. "Our collaboration with Pacira has grown into a shared effort to improve accelerating patient care," said ASA President Patrick Giam, M.D., FASA. "Through ongoing dialogue and shared initiatives, we are advancing education for anesthesiologists, strengthening advocacy efforts and supporting quality improvement across the specialty. Together, we are working to ensure anesthesiologists have the knowledge and resources to deliver the highest-quality care for patients." Earlier this spring, ASA and Pacira leadership met to discuss shared priorities and identify opportunities for collaboration. Those discussions led to the formation of joint workstreams focused on supporting the NOPAIN for Veterans Act and the reauthorization of the NOPAIN Act, both of which aim to ensure increased patient and provider access to qualifying non-opioid pain management options. Discussions also focused on opportunities to leverage quality improvement initiatives and data registries to enhance patient outcomes. Through the Corporate Supporter Program, ASA and Pacira have established a strategic relationship focused on advancing the specialty of anesthesiology and improving patient care. Pacira is on ASA's Center for Perioperative Medicine Corporate Advisory Council, a forum for dialogue among industry and physician leaders focused on advancing perioperative care, patient safety, quality improvement, and innovation. Pacira will also host an interactive Satellite Symposium at ANESTHESIOLOGY(R) 2026 on the TEAM model, with related content planned for future webinars and microlearning videos. "Pacira is proud to continue our collaboration with ASA to advance education, advocacy and quality improvement initiatives that help anesthesiologists deliver evidence-based, patient-centered care," said Frank D. Lee, chief executive officer of Pacira BioSciences. "Together, we are focused on expanding awareness of non-opioid options for pain management and supporting approaches that can improve patient outcomes throughout the post-surgical recovery journey." Established in 2010, ASA's Corporate Supporter Program is limited to 10 organizations. The program recognizes leading companies that demonstrate a sustained commitment to advancing the specialty of anesthesiology through support of education, innovation, and initiatives that benefit anesthesiologists and the Anesthesia Care Team. About Pacira BioSciences Pacira BioSciences, Inc. is a biotechnology company focused on advancing non-opioid approaches to pain management. The company works with clinicians and health care organizations to support education and evidence-based approaches that help improve patient care. For more information, visit pacira.com. About the American Society of Anesthesiologists Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 60,000 members organized to advance the medical practice of anesthesiology and secure its future. ASA is committed to ensuring anesthesiologists evaluate and supervise the medical care of all patients before, during and after surgery. ASA members also lead the care of critically ill patients in intensive care units, as well as treat pain in both acute and chronic settings.

Yahoo Finance
Aug 10th, 2026
Pacira's PCRX-201 gene therapy shows two-year durability in knee osteoarthritis Phase 1 trial

Pacira BioSciences reported positive two-year Phase 1 data for PCRX-201, its investigational gene therapy for moderate-to-severe knee osteoarthritis. The treatment was well tolerated and showed exploratory improvements in pain, stiffness, and function. The company has advanced Phase 2 enrollment and confirmed successful scale-up to a commercial-ready manufacturing process. PCRX-201 is the first gene therapy for knee osteoarthritis to combine sustained clinical results with RMAT and ATMP regulatory designations. Analysts project the company's revenue will reach $908.9 million by 2028, requiring 8.8% yearly growth. The most pessimistic forecasts estimate roughly $865 million revenue and $97 million earnings, with about 6% annual revenue growth. The core EXPAREL franchise currently drives most of Pacira's financial results.

WTOP
Aug 4th, 2026
Pacira: Q2 earnings snapshot.

Pacira: Q2 earnings snapshot. August 4, 2026, 4:39 PM BRISBANE, Calif. (AP) - BRISBANE, Calif. (AP) - Pacira Pharmaceuticals Inc. (PCRX) on Tuesday reported earnings of $4.7 million in its second quarter. On a per-share basis, the Brisbane, California-based company said it had profit of 12 cents. Earnings, adjusted for one-time gains and costs, came to 73 cents per share. The specialty drugmaker posted revenue of $192.4 million in the period. Pacira expects full-year revenue in the range of $735 million to $760 million. Keep Watching 1 dead, 7 injured after two-vehicle crash in Germantown This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on PCRX at https://www.zacks.com/ap/PCRX

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