In December 2020, investors from Paypal Holdings Inc. invested US$ 35.4 Mn in US-based biotechnology company Peptilogics Inc.

“With PLG0206, Peptilogics is developing a potential curative therapeutic solution for PJI built on its broad spectrum and biofilm-disrupting, anti-microbial properties that lead it to rapidly kill all bacteria living in complex biofilms, including the persister cells that are responsible for resistance to standard antibiotic treatment.

Pipeline corner presentation of PLG0206 will be the first glimpse of safety and efficacy data from its ongoing Phase 1b trial in periprosthetic joint infections (PJI)PITTSBURGH--(BUSINESS WIRE)--Peptilogics, a clinical stage biotechnology company, has completed the enrollment of a Phase 1b trial for PLG0206 in patients undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for treatment of a Periprosthetic Joint Infection (PJI) occurring after Total Knee Arthroplasty (TKA). The trial is an open-label dose-escalating study with two dose cohorts of seven patients each compared to historical controls.Peptilogics will present the interim top-line data on PLG0206 from their ongoing Phase 1b trial at the 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). The presentation will cover clinical safety and tolerability data, alongside reinfection rates for the low dose (3 mg/mL) cohort at the 3-month follow-up highlighting the potent antimicrobial properties of Peptilogics’ engineered peptide PLG0206 for the treatment of periprosthetic joint infection (PJI), a life-threatening complication that patients may develop following joint replacement surgery. In-depth analysis from the low dose cohort along with the readout from the high-dose cohort will be presented at an upcoming conference.“PJI is the last remaining problem in what is otherwise becoming a standard surgery all over the world. More than seven million total joint replacements will be performed annually in the seven major markets by 2030, which will require over 300,000 surgeries per year to try and resolve the infections,” said Jonathan Steckbeck, Chief Executive Officer of Peptilogics. “PJI is an enormous clinical and economic burden on the healthcare system due to the poor outcomes associated with the current standard of care, which includes multiple major surgeries and hospitalizations followed by high doses of antibiotics