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Phenome Health

Nonprofit research enabling early disease intervention

Overview

Phenome Health is a nonprofit research organization focused on extending the human healthspan, the years lived physically and cognitively well. It shifts healthcare from reacting to disease to predicting and preventing it by integrating multi-omic data, advanced analytics, and deep human phenotyping to find early signals of disease and enable earlier intervention. The organization combines genomics, proteomics, metabolomics, and other data with analytics to develop tools that support prevention and personalized care before symptoms appear. Its goal is to increase healthy years of life by making prevention and early, tailored intervention a practical part of healthcare.

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About Phenome Health

Simplify's Rating
Why Phenome Health is rated
C+
Rated B on Competitive Edge
Rated B on Growth Potential
Rated D+ on Differentiation

Industries

Data & AnalyticsHealthcare

Company Size

1-10

Company Stage

N/A

Total Funding

N/A

Headquarters

Washington

Founded

2021

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Simplify's Take

What believers are saying

  • Phenome Health says it won over $50 million in federal and state awards since 2024.
  • ARPA-H backed the Buck Institute partnership with up to $52 million.
  • BETA study enrollment with 4YouandMe began in 2026 for Type 2 diabetes.

What critics are saying

  • Phenome Health relies on grants; funding gaps hit operations when awards expire after 2026.
  • Lee Hood splits attention between Phenome Health and Buck Institute, weakening execution speed.
  • If ARPA-H support ends in 2027, Phenome Health's research engine collapses.

What makes Phenome Health unique

  • Leroy Hood founded Phenome Health in 2021, pairing systems biology with phenomics.
  • Buck Institute launched the Center for Human Healthspan with Phenome Health in 2025.
  • Phenome Health integrates genomic and phenomic data into a cloud infrastructure.

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Company News

GenomeWeb
Apr 25th, 2025
HudsonAlpha Launches Pilot Project to Study Genetics, Lifestyle of Alzheimer's Disease

NEW YORK - The HudsonAlpha Institute for Biotechnology said Friday that it is collaborating with Phenome Health and the Buck Institute for Research in Aging on a pilot study to examine how genetics and lifestyle influence a person's risk of developing Alzheimer's disease.

GeekWire
Sep 27th, 2023
Genomics Pioneer Lee Hood Joins Forces With The Buck Institute To Study Aging And Disease

Leroy Hood, CEO of Phenome Health and co-founder of the Institute for Systems Biology will co-lead a new center at the Buck Institute for Research on Aging. (Phenome Health Photo). Phenome Health, a Seattle research organization dedicated to what it calls a data-driven approach to human health and longevity, launched a partnership Wednesday with the Buck Institute for Research on Aging, based in Novato, Calif. The partnership establishes the Center for Phenomic Health at the Buck Institute, under the co-leadership of Buck CEO Eric Verdin and Seattle bioscience pioneer Leroy Hood. Hood founded Phenome Health in 2021 with the aim of understanding aging and detecting disease early by collecting multiple biological data points in individuals. That approach syncs up with the Buck Institute’s aim of extending human “healthspan,” the number of years of healthy aging, Hood told GeekWire

GeekWire
Apr 29th, 2023
Ai And The Future Of Human Health: Leroy Hood On The New Age Of ‘Scientific Wellness’

AI will help make it possible “to take each individual and map out exactly how they should optimize their health and keep track of it,” says Leroy Hood, a life sciences leader known for his past role in developing automated methods for sequencing DNA. (GeekWire File Photo / Dan DeLong)Biomedicine pioneer Leroy Hood says that artificial intelligence will play a key role in the future of healthcare by accelerating the progress of “scientific wellness,” an approach that he has championed for many years. Hood, co-founder of the Institute for Systems Biology, delves into this approach in his new book, “The Age of Scientific Wellness,” which he wrote with co-author Nathan Price, an ISB professor and chief scientific officer of Thorne HealthTech.On this week’s GeekWire Podcast, we talk with Hood about the book, how AI is key to the future of medicine, and what people can do now to live a healthy life. “AI will be the core foundation for the diagnosis and delivery of actionable possibilities for the information that comes from data-driven health in the future,” he said. “It will be able to take each individual and map out exactly how they should optimize their health and keep track of it.”The book explores the notion that, at some point during life, every person makes a transition from wellness to nascent disease. It might not be something we see, feel, or can sense

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