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Rapport Therapeutics

Develops precision neuromedicines for brain disorders

Overview

Rapport Therapeutics develops precision neuromedicines for neurological disorders. The company focuses on discovering and developing drugs that act only in disease-relevant areas of the brain to reduce symptoms with fewer side effects. Their discovery platform uses region-specific RAPs (Receptor Associated Proteins) to guide drug targeting to specific brain cells or regions, aiming to improve patient benefit. Unlike many peers, Rapport emphasizes selective targeting through RAPs and relies on experienced leadership to drive science and partnerships, with revenue from developing and potentially running clinical trials and related services. The goal is to provide treatments for drug-resistant epilepsies and mood disorders by delivering therapies that are active only where needed in the brain, reducing unwanted effects and improving outcomes.

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About Rapport Therapeutics

Simplify's Rating
Why Rapport Therapeutics is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

51-200

Company Stage

IPO

Headquarters

Boston, MA

Founded

2022

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What believers are saying

  • October 20, 2026 Phase 2 bipolar mania met primary and secondary endpoints.
  • Q2 2026 Phase 3 focal onset seizure trials FOCUS 1 and FOCUS 2 are enrolling.
  • The October 2026 raise funds operations through 2029, reducing near-term financing pressure.

What critics are saying

  • October 27, 2026 financing diluted holders and signaled heavy cash burn.
  • RAP-219 is the entire story; Phase 3 failure would crush the company.
  • FDA meetings in Q1 2027 and H2 2027 Phase 3 timing create execution risk.

What makes Rapport Therapeutics unique

  • RAP-219 targets TARPγ8, restricting AMPA modulation to disease-relevant brain regions.
  • October 2026 bipolar data validates a second indication beyond focal epilepsy.
  • Tenacia’s China rights expand RAP-219 development without surrendering global control.

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Funding

Total Funding

$854M

Above

Industry Average

Funded Over

5 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison Coming Soon

Benefits

  • Unlimited Paid Time Off
  • Commuter Benefits
  • Hybrid Work Options

Stock Price

Growth & Insights and Company News

6 month growth

-1%

1 year growth

-3%

2 year growth

-2%
Lake Oconee Breeze
Oct 28th, 2026
Lake Oconee Breeze

BOSTON and SAN DIEGO, Oct. 27, 2026 (GLOBE NEWSWIRE) -- Rapport Therapeutics, Inc. (Nasdaq: RAPP) (“Rapport” or the “Company”), a clinical-stage biotechnology company dedicated to the discovery and development of small molecule precision medicines for patients with neurological or psychiatric disorders, today announced that it has commenced separate underwritten public offerings of $200.0 million of shares of its common stock (the “common stock offering”) and $150.0 million aggregate principal amount of convertible senior notes due 2032 (the “notes offering” and together with the common stock offering, the “underwritten offerings”). In addition, Rapport intends to grant the underwriters in the common stock offering a 30-day option to purchase up to an additional $30.0 million of shares of its common stock under the same terms and conditions and intends to grant the underwriters a 30-day option to purchase up to an additional $22.5 million aggregate principal amount of notes solely to cover over-allotments, if any. Concurrently with the underwritten offerings, Rapport intends to enter into a share purchase agreement with a certain investor named therein (the “Investor”), in a separately negotiated transaction (the “concurrent private placement” and together with the underwritten offerings, the “offerings”) pursuant to which Rapport intends to offer and sell, and the Investor intends to purchase shares of Rapport’s common stock at the price per share of common stock in the common stock offering. The sale of shares to the Investor in the proposed concurrent private placement will not be registered as part of the common stock offering. The proposed offerings are subject to market and other conditions, and there can be no assurance as to whether or when the offerings may be completed, or as to the actual size or terms of the offerings.

Yahoo Finance
Oct 28th, 2026
Rapport Therapeutics stock tumbles on $350M capital raise.

Rapport Therapeutics stock tumbles on $350M capital raise. Investing.com - Rapport Therapeutics Inc (NASDAQ:RAPP) shares fell 20% in premarket trading Wednesday following the pricing of $350 million in combined stock and convertible note offerings. The clinical-stage biotechnology company priced an underwritten public offering of approximately $175 million in common stock at $21.00 per share, along with up to $25 million in pre-funded warrants at $20.999 per warrant. Rapport also priced $150 million in 2.25% convertible senior notes due 2032. Additionally, the company entered into a concurrent private placement with an investor for approximately $30 million of common stock at the same offering price. The convertible notes will accrue interest at 2.25% annually, payable semi-annually, and mature on December 1, 2032. The initial conversion rate is set at 37.3483 shares per $1,000 principal amount, equivalent to a conversion price of approximately $26.78 per share, representing a 27.50% premium over the offering price. Rapport expects to receive net proceeds of approximately $187.5 million from the common stock offering, $28.2 million from the private placement, and $145 million from the notes offering, after deducting underwriting discounts and expenses. The offerings are expected to close on or about October 30, 2026. The company intends to use the proceeds primarily to fund ongoing and planned clinical trials for RAP-219, its lead investigational drug, as well as for research and development, working capital, and general corporate purposes. Rapport stated the proceeds, combined with existing cash and investments, will enable it to fund operations through the end of 2029. Morgan Stanley, Leerink Partners, and Evercore ISI are serving as joint book-running managers for the underwritten offerings and placement agents for the concurrent private placement. BTIG and Citizens Capital Markets are acting as joint book-running managers for the common stock offering. Original Article

Yahoo Finance
Oct 22nd, 2026
Rapport shares rise 5.8% as RAP-219 hits Phase 2 goals in bipolar mania

Rapport Therapeutics said its drug RAP-219 met its primary and secondary endpoints in a Phase 2 trial in adults with acute mania in bipolar I disorder. Patients showed a 3.1 point placebo-adjusted improvement on the Young Mania Rating Scale, and the safety profile was generally mild to moderate. The result gives clinical proof of concept for a TARPγ8 selective AMPA modulator in bipolar mania. It could widen the commercial case for RAP-219 beyond focal epilepsy, subject to later-stage studies and regulatory talks planned from 2027. Rapport reported $20.0 million in revenue and a net loss of $137.16 million. Its shares, up 5.8%, trade at $25.06 after a weak month and quarter.

Yahoo Finance
Jun 5th, 2026
BTIG raises Rapport Therapeutics price target to $65 on accelerated RAP-219 bipolar mania trial timeline

Rapport Therapeutics has received positive analyst coverage, with BTIG raising its price target to $65 from $53 whilst maintaining a Buy rating. The upgrade followed clinical progress on RAP-219 in bipolar mania, with Phase 2 results brought forward to Q4 from H1 2027 due to strong enrollment. Truist initiated coverage with a Buy rating and $56 price target, citing RAP-219's potential as a differentiated epilepsy treatment with best-in-category prospects for focal onset seizures. The clinical-stage biopharmaceutical company, which develops small-molecule medicines for central nervous system disorders, reported first-quarter EPS of $(0.42), beating the $(0.71) consensus estimate. CEO Abraham Ceesay highlighted strong momentum across the RAP-219 programme and upcoming milestones in epilepsy and bipolar mania trials.

Associated Press
May 7th, 2026
Rapport Therapeutics reports $476.8M cash, RAP-219 shows 90% seizure reduction in Phase 2a follow-up

Rapport Therapeutics reported first quarter 2026 financial results alongside clinical updates for its lead drug candidate RAP-219. The company posted a net loss of $19.9 million, down from $24.1 million in the prior year period, and ended the quarter with $476.8 million in cash, expected to fund operations into the second half of 2029. Follow-up data from RAP-219's Phase 2a trial in focal onset seizures showed a 90% median reduction in clinical seizures during weeks 9-12. The company's Phase 3 programme in focal onset seizures remains on track for second quarter 2026 initiation, whilst topline results from its Phase 2 bipolar mania trial are now expected in fourth quarter 2026, ahead of previous guidance. Rapport also entered a licensing agreement with Tenacia Biotechnology for RAP-219's development in Greater China.

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