Remix Therapeutics

Remix Therapeutics

Biotech firm developing mRNA-degrading therapies

Overview

Remix Therapeutics develops medicines for rare diseases with a focus on targeted mRNA degradation. Its lead product REM 422 is an oral small molecule that degrades messenger RNA to stop production of disease-causing proteins. REM 422 is in Phase 1 trials for Adenoid Cystic Carcinoma and Acute Myeloid Leukemia, with FDA Orphan Drug Designation to support development. Remix funds its R&D through grants and partnerships, aiming to bring safe, effective therapies to patients and expand its portfolio.

About Remix Therapeutics

Simplify's Rating
Why Remix Therapeutics is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

51-200

Company Stage

Growth Equity (Venture Capital)

Total Funding

$224.7M

Headquarters

Cambridge, Massachusetts

Founded

2018

People at Remix Therapeutics

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Simplify's Take

What believers are saying

  • $100M financing funds operations into 2028 and enables 2027 Phase 2 readouts for REM-422.
  • 43% response and 100% disease control in biomarker-positive ACC validates first-in-class potential.
  • Fast Track and Orphan Drug designations accelerate development and offer market exclusivity for ACC and AML.

What critics are saying

  • Phase 2 ACC data may fail to show tumor reduction due to MYB resistance by mid-2027.
  • FDA may reject REM-422 for AML if combination therapy lacks durable response within 18–30 months.
  • Hepatotoxicity in Phase 1 AML cohort could delay registrational trial by 18 months with high probability.

What makes Remix Therapeutics unique

  • Remix targets undruggable MYB oncogene via first-in-class selective oral mRNA degrader.
  • REMaster platform uses data science to identify RNA-modulating small molecules for gene control.
  • Combines Passage Bio infrastructure with REM-422's Phase 1/2 clinical data and Orphan Drug status.

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Funding

Total Funding

$224.7M

Above

Industry Average

Funded Over

5 Rounds

Growth Equity VC funding comparison data is currently unavailable. We're working to provide this information soon!
Growth Equity VC Funding Comparison
Coming Soon

Benefits

Wellness Program

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

-1%

2 year growth

1%
The Manila Times
Nov 3rd, 2025
Remix Therapeutics to Present at Guggenheim Second Annual Healthcare Innovation Conference

Remix Therapeutics to present at Guggenheim Second Annual Healthcare Innovation Conference. WATERTOWN, Mass., Nov. 03, 2025 (GLOBE NEWSWIRE) - Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address the underlying drivers of disease, today announced that Peter Smith, Ph.D., Co-Founder and Chief Executive Officer of Remix, will present a corporate overview at the Guggenheim Second Annual Healthcare Innovation Conference on November 10, 2025 at 2:15 PM ET The Remix management team will also be hosting one-on-one meetings with investors. For those investors interested in scheduling a meeting, please contact your Guggenheim representative. About Remix Therapeutics Remix Therapeutics is a clinical-stage biotechnology company developing novel small molecule therapies designed to reprogram RNA processing and address disease drivers at their origin. Remix's REMaster(TM) technology platform leverages cutting-edge data science, biomolecular sciences and chemistry approaches to identify orally administered compounds that modulate gene expression. Remix's innovative therapeutic approach led to the discovery of REM-422, a first-in-class RNA processing modulator in oncology, now being evaluated in Phase 1 clinical studies to treat acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (HR-MDS) and adenoid cystic carcinoma (ACC). For more information visit www.remixtx.com.

GlobeNewswire
Mar 31st, 2025
Remix Therapeutics To Present At Stifel 2025 Virtual Targeted Oncology Forum

WATERTOWN, Mass., March 31, 2025 (GLOBE NEWSWIRE) -- Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address the underlying drivers of disease, today announced that Peter Smith, Ph.D., Co-Founder and Chief Executive Officer of Remix, will present a corporate overview at the Stifel 2025 Virtual Targeted Oncology Forum on Tuesday, April 8, 2025, at 1:00 p.m. ET.For investors interested in scheduling a one-on-one meeting with the Remix management team, please contact your Stifel representative.About Remix TherapeuticsRemix Therapeutics is a clinical-stage biotechnology company developing novel small molecule therapies designed to reprogram RNA processing and treat disease. The REMaster™ technology platform facilitates RNA processing pattern identification, leveraging these learnings to modulate gene expression. Remix’s innovative therapeutic approach has the potential to alter the way genes are read from the genome, to correct, enhance, or eliminate the gene message, thereby addressing disease drivers at their origin. For more information visit www.remixtx.com.Contacts:Media Contact:Lisa BuffingtonBuffington [email protected] Contact:Will O'ConnorPrecision [email protected]

Marketing-Interactive
Mar 4th, 2025
REV Media Group and Remix reshape affiliate marketing in MY with new solution

REV Media Group has teamed up with Remix to launch REV Affiliate+, an end-to-end affiliate marketing solution designed to help brands increase customer reach and sales through affiliate marketing in Malaysia.

PYMNTS
Dec 3rd, 2024
ThredUp Sells European Business Remix to Focus on US

ThredUp acquired Remix in July 2021, a $28.5 million deal designed to give it a foothold in the then-emerging European resale market, while providing the Bulgaria-based Remix with the resources to scale faster than it would on its own.

PR Newswire
Nov 26th, 2024
Remix Therapeutics To Present At 7Th Annual Evercore Healthconx Conference

CAMBRIDGE, Mass., Nov. 26, 2024 /PRNewswire/ -- Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address the underlying drivers of disease, today announced that Peter Smith, Ph.D., Co-Founder and Chief Executive Officer of Remix, will present a corporate overview at the 7th Annual Evercore HealthCONx Conference in Miami on Tuesday, December 3, 2024, at 3:25 p.m. ET. For investors interested in scheduling a one-on-one meeting with the Remix management team, please contact your Evercore representative. About Remix TherapeuticsRemix Therapeutics is a clinical-stage biotechnology company developing novel small molecule therapies designed to reprogram RNA processing and treat disease. The REMaster™ technology platform facilitates RNA processing pattern identification, leveraging these learnings to modulate gene expression

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