SHINE Technologies

SHINE Technologies

Fusion-based neutron production for isotopes

Overview

SHINE Technologies produces neutrons using fusion-based technology for practical applications in medicine, industry, and security. Its neutron source supports advanced industrial inspection and the production of medical isotopes used in diagnostic imaging and cancer treatment, as well as contraband detection. The neutron source operates through SHINE’s four-phase pathway to fusion energy production, enabling reliable, commercially viable neutron production rather than basic research. The company differentiates itself by focusing on immediate, real‑world deployments of fusion-based neutron production for diverse customers, guided by industry veterans on its board and a growth-oriented strategy to expand market applications. The goal is to commercialize fusion-powered neutron production to create safer, healthier, and cleaner outcomes while expanding its market reach in medical, industrial, and security sectors.

About SHINE Technologies

Simplify's Rating
Why SHINE Technologies is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Industrial & Manufacturing

Energy

Defense

Healthcare

Company Size

201-500

Company Stage

Late Stage VC

Total Funding

$1.2B

Headquarters

Janesville, Wisconsin

Founded

2010

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Simplify's Take

What believers are saying

  • DOE issued a $263 million conditional loan commitment on April 9, 2026.
  • SHINE closed a $240 million Series E in February 2026, led by NantWorks.
  • SHINE and Newcleo launched June 18, 2026 recycling collaboration for used fuel.

What critics are saying

  • Chrysalis remains 75% complete and slipped from 2022 to 2029.
  • DOE funding still depends on technical, legal, environmental, and financial conditions.
  • A failed Chrysalis launch strands SHINE's capital-heavy model before fusion power arrives.

What makes SHINE Technologies unique

  • SHINE commercialized fusion-derived neutrons before rivals, selling isotopes and testing services today.
  • Its Chrysalis plant targets first domestic commercial Mo-99 supply, backed by NRC licensing.
  • European Ilumira authorization on May 29, 2026 broadens SHINE's oncology platform.

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Funding

Total Funding

$1.2B

Above

Industry Average

Funded Over

18 Rounds

Late VC funding comparison data is currently unavailable. We're working to provide this information soon!
Late VC Funding Comparison
Coming Soon

Benefits

Flexible Work Hours

Growth & Insights and Company News

Headcount

6 month growth

3%

1 year growth

-1%

2 year growth

-2%
World Nuclear News
Jun 18th, 2026
Shine, Newcleo join up to close nuclear fuel cycle.

Shine, Newcleo join up to close nuclear fuel cycle. Thursday, 18 June 2026 US fusion energy company Shine has joined a consortium that is working to build US nuclear fuel recycling capability. It has also agreed to work with France-based company Newcleo to link Shine's recycling capabilities with Newcleo's reactors, which are designed to run on recycled fuel. The MARIE (for Model for the Assessment of Reprocessing and Recycle with Innovative Execution) consortium is led by the independent non-profit EPRI research organisation and funded under the US Department of Energy's Advanced Research Projects Agency-Energy's (ARPA-E) CURIE programme. It is working to build an optimisation tool the US nuclear industry could use to evaluate and underwrite the first commercial used fuel recycling facilities. Shine is targeting a pilot facility capable of processing 100 tonnes of used nuclear fuel per year in the early 2030s - the kind of facility MARIE is designed to help underwrite. "Roughly 90,000 metric tonnes of used nuclear fuel sit in US storage today, and Shine's strategy is to turn that inventory into a strategic energy asset," the company said. Shine's role covers the security, regulatory, and commercial questions facing a US nuclear recycling industry, drawing on its experience in licensing its Chrysalis medical isotope production facility as well as its experience as a commercial isotope producer to assess the markets for valuable isotopes recoverable from used fuel. "Recycling effectively makes nuclear fuel a renewable resource, reshaping the next era of clean energy. The companies that figure out how to licence and build the facilities will set the pace for US recycling, and that's the work we're doing in this consortium," the company's founder and CEO Greg Piefer said. Technical collaboration In a separate announcement, Shine and Newcleo said they have agreed to collaborate on advancing innovative technologies for the recycling of used nuclear fuel. They will assess how Shine could supply Newcleo with materials from the used nuclear fuel of traditional reactors to manufacture MOX fuel, and how Shine could recycle spent fuel from Newcleo's reactors. The companies also intend to jointly pursue US federal funding opportunities and explore additional opportunities for collaboration across both the US and European Union, where they say used fuel stockpiles represent a growing strategic priority. Newcleo is developing advanced modular reactors cooled by liquid lead, and the facilities to produce mixed-oxide - or MOX - fuel to power them. Shine is developing nuclear fuel reprocessing technologies aimed at enabling the efficient and proliferation-resistant extraction of uranium and plutonium from existing used nuclear fuel inventories. The MOX fuel manufacturing capabilities that Newcleo is advancing can convert those materials into new fuel suitable for use in advanced reactor systems, the companies said. "Closing the fuel cycle will require deep, industry-wide collaboration that brings together expertise from across the nuclear fuel supply chain. Today marks an important step in that direction, combining Shine's recycling capabilities with Newcleo's advanced fuel manufacturing and reactor technologies," Newcleo founder and CEO Stefano Buono said. "Recycling spent nuclear fuel solves two problems at once. It addresses decades of accumulated waste and removes the fuel supply constraint on expanding the reactor fleet. Working with Newcleo connects our capabilities directly to reactors designed to run on recycled fuel. That closed fuel cycle effectively makes nuclear energy renewable and fundamentally changes its economics," Piefer said. The companies plan to begin technical scoping this year, with joint federal funding proposals to follow. Last year, Newcleo signed an agreement with US-based sodium-cooled fast-reactor developer Oklo to develop advanced fuel fabrication and manufacturing infrastructure in the USA. It has begun pre-application engagement with the US Nuclear Regulatory Commission to support the future licensing of its first Lead-cooled Fast Reactor and an associated MOX fuel fabrication facility.

PR Newswire
May 29th, 2026
SHINE's Ilumira gains European approval, expands nuclear medicine platform with $269M funding

SHINE Technologies has secured European marketing authorisation for Ilumira, its non-carrier-added lutetium-177 (Lu-177), opening a major market for the radioisotope used in targeted cancer therapy. The approval allows SHINE to sell Lu-177 across the European Union. The Wisconsin-based company is building an integrated nuclear medicine platform spanning diagnostic and therapeutic radioisotopes. In January, SHINE acquired a US isotope manufacturing facility, adding diagnostic products including Tc-99m generators and cardiac imaging agents used in millions of procedures annually. Recent milestones include a $240 million Series E funding round led by Dr Patrick Soon-Shiong in February and a $263 million conditional loan commitment from the US Department of Energy in April to complete its Chrysalis facility, designed to become the world's largest medical isotope production site.

PR Newswire
May 12th, 2026
SHINE names new CFO, CLO, CSO and board director after $240M Series E and $263M DOE loan

SHINE Technologies has appointed three senior leaders and a board director following a $240 million Series E round led by Dr Patrick Soon-Shiong, the acquisition of Lantheus's isotope distribution business, and a $263 million conditional loan commitment from the US Department of Energy. Kyle Stacey joins as chief financial officer from Exact Sciences, where he spent 17 years helping build the company to a $23 billion acquisition. David Willbrand becomes chief legal officer, having previously served as founding CLO of Pacaso. Ralph Alexander, former president and CEO of Talen Energy, joins the board of directors. Chris Lee, SHINE's CFO since 2021, transitions to chief strategy officer. The Wisconsin-based company has commercialised fusion technology for medical isotope production and neutron testing markets.

Third News
Apr 9th, 2026
SHINE secures $263M US Department of Energy loan for world's largest medical isotope production facility

SHINE Technologies has received a conditional commitment for a $263 million loan from the US Department of Energy to complete Chrysalis, set to become the world's largest medical isotope production facility. The facility will produce molybdenum-99, used in over 40,000 daily medical procedures for diagnosing heart disease and cancer. Chrysalis will provide the first domestic commercial supply of Mo-99, reducing reliance on international imports from Europe, South Africa and Australia. The facility will use proprietary fusion technology combined with recycled liquid uranium targets to produce millions of doses annually. The project will create approximately 200 construction jobs and 150 permanent positions in Janesville. The initiative follows over 15 years of collaboration with US National Laboratories and support from the National Nuclear Security Administration.

Madison Startups
Mar 27th, 2026
SHINE, C-Ray Therapeutics partner.

SHINE, C-Ray Therapeutics partner. by Taylor Kennedy SHINE Technologies has entered a supply agreement with C-Ray Therapeutics, a global radiopharmaceutical CRDMO, the company announced recently. According to a release, C-Ray will supply SHINE's n.c.a. Lu-177 to Chinese radiopharmaceutical developers, biotechnology companies and healthcare institutions. "We are pleased to partner with C-Ray," SHINE Technologies Founder and CEO Greg Piefer said in a statement. "This collaboration reflects SHINE's ability to serve growing demand for n.c.a. Lu-177 in China while maintaining strong supply for customers in the U.S. and other global markets. By combining C-Ray's integrated development and manufacturing platform with our large-scale isotope production, we can help advance pipeline innovation and expand patient access to life-saving targeted radioligand therapies." Under the terms of the agreement, SHINE's Cassiopeia facility, one of North America's largest n.c.a. Lu-177 production sites, will supply C-Ray.

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