Overview

Substrate Bio operates AI-native data-production infrastructure for biology, connecting computational models with real-world experimentation. The company runs a network of autonomous, robotics-powered wet labs, starting in London with a second planned for San Francisco, running standardized experiments with full provenance, metadata, and quality control. Researchers access the labs via API, submitting experiment parameters and receiving structured data and metadata, while foundation models help design assay selections, cell systems, and gene panels. What sets Substrate Bio apart is its closed feedback loop, where better data improves its models and better models design better experiments. The goal is to make biological experimentation as programmable and scalable as computation itself.