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Terremoto Biosciences

Develops lysine-based covalent medicines

Overview

Terremoto Biosciences develops covalent medicines in the drug development space, focusing on creating strong chemical bonds between drug molecules and target proteins via lysine-based covalency. This expands the range of druggable targets beyond the traditional cysteine-focused approach, aiming to produce medicines with improved efficacy across a broader set of diseases. The company’s product strategy centers on researching, developing, and commercializing these novel covalent therapies for the healthcare sector, with revenue expected from the sale of approved drugs. Terremoto emphasizes an inclusive culture that brings together chemists, biologists, and drug developers to advance therapeutics. Overall goal: bring safe, effective, lysine-targeted covalent medicines to patients by progressing candidates through development to commercialization.

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About Terremoto Biosciences

Simplify's Rating
Why Terremoto Biosciences is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

11-50

Company Stage

Series C

Total Funding

$358M

Headquarters

San Francisco, CA

Founded

2021

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What believers are saying

  • June 2026 Series C raised $108 million from RA Capital, Novo Holdings, and OrbiMed.
  • FDA Fast Track for TER-2013 in May 2026 accelerates oncology development and partnering.
  • TER-4480 entered the clinic in Q3 2026, broadening the pipeline beyond cancer.

What critics are saying

  • TER-2013 remains early Phase 1; clinical failure would kill the platform thesis.
  • AKT1 selectivity may not translate into durable efficacy against AkT-pathway resistance mechanisms.
  • If TER-4480 misses IND or HHT data disappoints, investors lose confidence quickly.

What makes Terremoto Biosciences unique

  • Lysine-based covalent chemistry expands targets beyond cysteine, supporting broader druggable biology.
  • TER-2013 targets AKT1 selectively, aiming for cleaner PI3K/AKT inhibition than older drugs.
  • Christensen and Baum bring Mirati, Pfizer, and oncology-development credibility to execution.

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Funding

Total Funding

$358M

Above

Industry Average

Funded Over

3 Rounds

Series C funding is usually for startups that are doing well and are looking for more money to fuel major growth, such as acquiring other companies, expanding into global markets, or launching new product lines. Investors typically include larger venture capital firms and private equity.
Series C Funding Comparison
Above Average

Industry standards

$50M
$50M
$62M
$100M
$108M

Company News

BioCentury
Aug 7th, 2026
Mirati vet Christensen named CEO of well-funded start-up Terremoto.

Mirati vet Christensen named CEO of well-funded start-up Terremoto. Plus: Jennifer Taubert retiring after long career at J&J and more. By BioCentury Staff August 7, 2026 5:47 PM PDT Terremoto Biosciences Inc., a California start-up dedicated to AKT1 biology, has a new CEO in James Christensen, the Mirati Therapeutics Inc. and Pfizer Inc. (NYSE:PFE) alum who has been serving as head of R&D. The announcement comes a few months after the company raised $108 million in a series C round. Christensen, who is a venture partner at OrbiMed, succeeds Charles Baum, who becomes executive chairman. Peter Thompson, co-founder and the current chairman, will remain on the company's board. Christensen was CSO of Mirati and, before that, was head of oncology precision medicine in Pfizer's oncology research unit. He retains the title of president... Just want immediate access to this one article? Purchase it now.

MedWatch
Apr 16th, 2026
Novo Holdings invests in US biotech company.

Novo Holdings invests in US biotech company. The funding will help advance new drugs for cancer and a rare bleeding disorder through early clinical trials. 16 April 2026at 14:56 US-based Terremoto Biosciences has raised USD 108m in a Series C funding round, with participation from Novo Holdings. Try MedWatch for 14 days - and get access to all content. * Continues as a recurring subscription and is billed annually. Can be terminated after 5 months of subscription with 1 month's notice at the end of a month. Minimum price is up to €539.58 excl. VAT corresponding to 7 months of subscription. Right of withdrawal under the Consumer Contracts Act. Read more here. ** Continues as a recurring subscription for 3 months at a time. Minimum price €286.00 excl. VAT. Can be terminated with 1 month's notice at the end of a 3-month period. Right of withdrawal under the Consumer Contracts Act. Read more here.

Fierce Biotech
Apr 15th, 2026
Terremoto takes $108M series C to fuel clinical trials of AKT1 inhibitors

Terremoto Biosciences has spelt out how the California biotech will use a $108 million series C round to continue its efforts to broaden the covalent drug alphabet. | Terremoto Biosciences has spelt out how the California biotech will use a $108 million series C round to continue its efforts to broaden the covalent drug alphabet.

Resonate Group Incorporated
Apr 15th, 2026
Terremoto takes $108M series C to fuel clinical trials of AKT1 inhibitors.

Terremoto takes $108M series C to fuel clinical trials of AKT1 inhibitors. * April 15, 2026 Terremoto Biosciences has spelt out how the California biotech will use a $108 million series C round to continue its efforts to broaden the covalent drug alphabet. Fields (*) Mark are Required

BioSpace
Jan 10th, 2025
Terremoto Biosciences Appoints James Christensen, Ph.D., As President And Head Of Research & Development

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Terremoto Biosciences, a biotechnology company developing first- and best-in-class targeted therapeutics, today announced the appointment of James Christensen, Ph.D., as President and Head of Research & Development.“The most important predicter of successful drug development is a team of people who have successfully developed a therapy from discovery to regulatory approval,” said Charles Baum, M.D., Ph.D., Chief Executive Officer of Terremoto. “I am honored to once again be working alongside Jamie on compelling science and an innovative approach to developing groundbreaking medicines with the goal of changing the treatment paradigm for people with devastating diseases. His addition to the leadership team positions Terremoto to execute on our mission and deliver much needed treatments to patients.”Terremoto’s Board chairperson, Peter Thompson, M.D., added, “Jamie has provided exceptional guidance and expertise as one of our scientific advisors, and I am thrilled for him to join the leadership team at such a pivotal moment in the company’s growth. His extensive experience in precision oncology drug development and proven track record in advancing high-impact medicines from discovery through regulatory approval aligns perfectly with our goal to discover and develop novel therapies for patients in need.”Terremoto is harnessing the power of an exceptional chemistry team and expanded covalent alphabet to create highly targeted therapeutics for a variety of severe diseases. The company is applying its unique capabilities to develop differentiated best-in-class therapies against established drug targets and first-in-class medicines against high-value, previously undrugged targets in oncology and beyond.“The outstanding team at Terremoto has already built the foundation for innovative drug development and delivered on high-quality development candidates, providing an immense opportunity to be on the cutting edge of targeted oncology and addressing other unmet medical needs,” said Dr. Christensen

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