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UCLA Health is a large, integrated healthcare system in Los Angeles that operates multiple hospitals and a wide network of primary- and specialty-care clinics. It provides medical services across many fields—from organ transplantation and cardiac surgery to neurosurgery and cancer treatment—and combines patient care with biomedical research. Its hospitals and physicians diagnose and treat complex illnesses and bring the latest medical discoveries into practice. UCLA Health stands out because it runs a comprehensive, highly ranked set of facilities (including Ronald Reagan UCLA Medical Center and UCLA Mattel Children’s Hospital) and emphasizes leading research, education, and specialized care across a broad regional network. The organization aims to deliver high-quality medical care while advancing medical knowledge and sharing new treatments with patients locally and globally.
Industries
Healthcare
Company Size
10,001+
Company Stage
Grant
Total Funding
$25.3M
Headquarters
Santa Monica, California
Founded
1955
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UCLA Health researchers awarded $1.75M grant to study liver toxicity from Duchenne muscular dystrophy treatment. September 24, 2026 UCLA Health researchers have been awarded a $1.75 million federal grant to investigate why some Duchenne muscular dystrophy patients develop liver toxicity after receiving a gene therapy treatment meant to prevent muscle deterioration. Funded by a U.S. Department of Defense grant through 2029, the research will investigate liver toxicity caused by treatment with Elvidys, a one-time gene therapy treatment to help Duchenne muscular dystrophy patients produce a functional version of a missing muscle-protecting protein called micro-dystrophin. One potential side effect of the treatment is liver injury and acute liver failure among some individuals. Duchenne muscular dystrophy is one of the most common genetic diseases of childhood for boys and causes rapid muscle deterioration. The disease causes loss of ambulatory function by age 12, loss of upper arm use in teen years and eventually heart and respiratory failure that leads to death in their 20s. There is no known cure. The new study will be led by UCLA neurologist Dr. Melissa Spencer in collaboration with neurologist Dr. Perry Shieh, Assistant Professor Tayo Ikotun of the Department of Molecular & Medical Pharmacology and Professor Alex Huk of the Department of Psychiatry and Biobehavioral Sciences. They will use biological samples collected from patients before and after treatment to investigate the immune, molecular and physiological responses associated with liver injury and identify factors that may place certain patients at great risk of liver toxicity. The long-term goal of the study is to develop ways to predict, prevent and effectively manage liver toxicity and thereby improve safety of the treatment and other similar gene therapies. Articles: Services: Team member. Melissa Spencer, PhD Media contact. Will Houston
UCLA scientists engineer ready-to-use cancer-fighting T cells for solid tumors. A new stem cell-based platform produces uniform T cells that attack solid tumors two ways while avoiding a dangerous side effect Engineered T cells, designed to recognize and attack tumor cells, illustrating a new approach to developing off-the-shelf cell therapies for solid tumors. Credit: Lili Yang Lab/UCLA September 8, 2026 By Linda Wang Key takeaways. * UCLA researchers have developed a way to mass-produce cancer-fighting T cells from blood stem cells found in cord blood, engineered to target a protein found in many solid tumors - creating uniform batches instead of custom treatments for each patient. * This way, scientists ensure that all the T cells they produce carry the same single tumor-targeting receptor, avoiding the random receptors that can attack healthy tissue and cause a dangerous condition called graft-versus-host disease. * In mouse models of ovarian cancer and melanoma, a single dose kept tumors in check and extended survival, outperforming conventional donor T cells, which caused toxic side effects in the same tests. T cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, but with one key difference: CAR T-cell therapy can only spot proteins that naturally appear outside of a cancer cell. TCR therapy, however, can also catch small protein fragments from inside the cell, which get carried to the surface and displayed like little name tags. This ability gives TCR therapy access to a much wider range of cancer targets - a big deal for solid tumors, since most of what makes those cells cancerous is hidden inside them, not on the surface. But there's a bottleneck: In currently available approaches, each dose has to be custom-made from a patient's own T cells, a process that can take weeks and cost well into the six figures. Researchers have also explored engineering donor-derived T cells instead, which could be manufactured in advance and used off-the-shelf for many patients, but this method is largely limited because it carries the risk of graft-versus-host disease, a dangerous condition in which transplanted immune cells attack healthy tissues. UCLA scientists have developed an approach that sidesteps both hurdles at once. In a study published in Cell Reports Medicine, the team describes a scalable method for producing uniform batches of cancer-fighting T cells from blood stem cells found in donated cord blood, engineered to recognize a protein found in many solid tumors. In mouse models of ovarian cancer and melanoma, a single dose of these engineered cells, called AlloESO-T cells, kept tumors in check and extended survival without triggering dangerous side effects. "This platform brings us closer to a future where the product is already made, frozen and ready to go as soon as the patient needs," said co-senior author Lili Yang, a professor of microbiology, immunology and molecular genetics and a member of the UCLA Broad Stem Cell Research Center and the UCLA Health Jonsson Comprehensive Cancer Center. Safe by design. Rather than starting with mature, donor-derived T cells, the researchers began a step earlier - with blood stem cells found in cord blood, which naturally give rise to every type of blood and immune cell. They then added a gene for a receptor that targets NY-ESO-1, a protein found in many solid tumors. Fragments of NY-ESO-1 get pushed to the outer surface and displayed there, name-tag style. The researchers then grew these engineered stem cells into T cells in the lab. Introducing that receptor this early keeps the stem cells from developing their own natural receptors as they mature. That matters because conventional donor-derived T-cell therapies start from T cells that already carry a random assortment of natural receptors, which must be silenced with extra gene editing, since any of them could attack the patient's healthy tissue. "Stem cells are undifferentiated - they're not yet mature T cells with a fixed receptor already in place," said co-first author Yichen (John) Zhu, a graduate student in the UCLA Broad Stem Cell Research Center Training Program. "When we differentiate our engineered stem cells into T cells, essentially all of the resulting cells carry the same receptor and go after the same tumor target." Closing the escape hatch on tumor cells. Solid tumors are notorious escape artists, often shedding or hiding the very markers a therapy is built to find. To guard against that, the AlloESO-T cells also carry natural killer cell receptors - a separate detection system - that detect stress signals many tumor cells display on their surface. That gives the therapy a second, backup way to recognize and destroy tumor cells, independent of whether the NY-ESO-1 name tag is present at all. "Solid tumors are very diverse," Zhu said. "Some tumor cells lose or hide the antigen a therapy is designed to find - what we call antigen escape. When that happens, a therapy built around a single target loses its grip. Our stem cell-derived cells still have a second mechanism to kill those tumor cells." In lab tests against human melanoma, ovarian and prostate cancer cells, that backup let the engineered cells destroy tumor cells the main NY-ESO-1 route couldn't catch on its own - closing an escape route that limits many single-target therapies. Controlling tumors, extending survival. In mouse models of ovarian cancer, a single dose led to durable tumor control and extended survival, while a comparison group treated with T cells engineered from mature donor T cells kept the tumors only partially in check and developed graft-versus-host disease. A melanoma model told the same story: The AlloESO-T cells slowed the cancer and delayed its return, while the comparison cells offered only fleeting control. The difference came down to where the cells went. After a single infusion, the AlloESO-T cells multiplied roughly 100-fold, traveled to the tumor, expanded where they were needed and stayed active for weeks - while largely leaving healthy organs alone. In contrast, the conventionally engineered cells spread through the liver and lungs and triggered the toxicity this new approach is designed to avoid. Cheaper to make at massive scale. Perhaps the platform's biggest promise is that it could put T-cell therapies within reach for many more patients. Because the therapy starts from stem cells rather than fully formed T cells collected one patient at a time, manufacturing can run at a scale that custom-made therapies can't match. "From a small number of cord blood stem cells, we can generate trillions of therapeutic cells - enough for thousands of doses - within about six weeks," said co-senior author Yanruide (Charlie) Li, a postdoctoral scholar in the Yang lab. "At an estimated $5,000 per dose, this approach would be far more accessible than today's therapies." One platform to target many solid cancers. Many solid tumors don't carry a good target that naturally appears on their surface for a therapy to grab onto, which leaves those patients with few options. But because this approach uses an engineered T-cell receptor - which recognizes targets that originate inside the tumor cell, displayed as fragments on its surface - it could reach cancers that have been hard to treat. "We're not just presenting one therapy for one target. We want to share the platform itself," Li said. "As long as a receptor for a given cancer antigen has been validated, we can build it into this system and generate T cells specific to that target." This AlloESO-T platform builds on manufacturing groundwork the Yang lab has already laid for its CAR-NKT platform - a related but distinct off-the-shelf immunotherapy approach. The team, which has already partnered with the UCLA Health Center for Advanced Biotherapies to produce clinical-grade cells for that program, expects to draw on that same manufacturing relationship to scale up AlloESO-T, which could help move it toward a clinical trial faster than starting from scratch. Additional authors include Jiaji Yu, Yu Jeong Kim, Yanxin Tian, Zhe Li, Yuning Chen, Zibai Lyu, Enbo Zhu, Annabel S. Zhao, Nathan Ma, Catherine Zhang, Adam Kramer, Matthew Wilson, Ryan Hon, Yu-Chen Wang, Siyu Lin, Xinyuan Shen, Zoe Hahn, Yuchong Zhang and Aijun Wang. The therapeutic cells described in this study have been used in preclinical tests only; it has not been tested in humans in clinical trials or approved by the FDA as safe and effective for use in humans. This research was supported by the California Institute for Regenerative Medicine, the UCLA Molecular Biology Institute, the UCLA Office of the Chancellor and the UCLA Goodman-Luskin Microbiome Center. Articles: Cancer Center member. Media contact. Ani Vahradyan 310-968-6144
Low-income patients at UCLA Health scramble to find new doctors as contract ends. Thousands of low-income patients are losing access to doctors at UCLA Health after a Medi-Cal contract expired June 30. (Los Angeles Times) Sept. 5, 2026 3 AM PT See more from the L.A. Times in Google Search. Set Prospering In America, Inc. as preferred Thousands of low-income patients, some seriously ill, are scrambling to find new doctors as they lose access to UCLA Health physicians after a longtime Medi-Cal contract was not renewed. Under the contract that expired June 30, UCLA had been providing specialty care to 9,000 medically frail patients from Health Care LA, an association of nonprofit clinics that serve patients covered by Medi-Cal, the state program for the poor. "Many of these patients have been waiting for months to be seen by UCLA specialty medicine providers and are now being told they cannot receive the care they desperately need," Health Care LA said in a Thursday news release. The patients had gone to UCLA for cancer and infectious-disease treatments, high-risk women's services, major organ transplants and other specialty medicine care, the association said. A Friday news conference that Health Care LA had scheduled to detail the problems patients faced in getting care was abruptly canceled when the two sides said they had reached a tentative agreement on how to transition the patients to other doctors over the next year. "To help ensure a smooth transition for patients, both organizations have agreed that established UCLA Health patients, individuals with existing appointments, and patients requiring other agreed-upon services will continue to be cared for at UCLA Health facilities," Phil Hampton, a university spokesman, said in a statement. Although some patients will continue to be seen by UCLA doctors, he said, "accepting an unlimited number of new referrals presents challenges given existing capacity constraints and the need to preserve timely access for existing patients." Sabra Matovsky, chief executive of Health Care LA, said in an interview on Thursday that UCLA had declined to renegotiate the contract. "They never even asked us for a raise," she said, "They just want us out." March 29, 2026 She said that university officials had pointed to "capacity issues" at Ronald Reagan UCLA Medical Center in Westwood, including in the emergency room and dozens of specialty clinics. "To solve this by pushing out Medi-Cal patients while you continue to expand and market and take on other patients is not a solution," Matovsky said. Hampton said UCLA had offered to extend the contract, but Health Care LA rejected the offer. The end of the Medi-Cal contract disappointed some UCLA medical professionals who have been urging the public university to provide care to more of L.A. County's low-income residents. "It feels like this is profits over patients," said Dr. Patrick Samones, a fellow at UCLA Health, who trained at the university in family medicine. "UCLA is one of L.A.'s most important healthcare institutions," said Samones, who represents members of the Committee of Interns and Residents, which is part of Service Employees International Union. "We feel it has a duty to serve all Californians." In recent years, UCLA Health has been expanding fast and now has almost 300 locations throughout Southern California, including in wealthier places such as Montecito, Malibu and Westlake Village. At the same time, it provides less care to Medi-Cal patients than its sister university health systems: UC Irvine, UC San Diego, UC San Francisco and UC Davis, according to university statistics. Last year, about 15% of UCLA Health's net patient service revenue came from Medi-Cal, according to the university health systems' annual report. The four other UC health systems each received about 22% of that revenue from Medi-Cal. About 40% of L.A. County residents are insured by Medi-Cal, according to a recent report by the California Health Care Foundation. July 20, 2026 Hampton said the net patient service revenue data from the annual report doesn't capture UCLA's "extensive contributions to caring for Medi-Cal patients" and isn't "a fair basis for comparing academic health systems." He added that with the university's expansion of clinics, "we are providing substantial specialty care to Medi-Cal and Medicare patients" throughout L.A. County. "Unlike county-owned hospitals, UCLA Health relies almost exclusively on patient care revenue to fund operations, expand access, recruit clinicians and invest in facilities and technology," he said. Hampton said UCLA has other contracts to serve Medi-Cal patients, which will continue. The health system also provides more than $270 million in unreimbursed care for low-income patients each year, he said, as well as primary and urgent care for people experiencing homelessness. In addition, UCLA is spending $500 million to create a new neuropsychiatric hospital in Los Angeles' Mid-Wilshire neighborhood, he said. "We continue to fortify our region's safety net despite growing access demands and challenges," Hampton said. In the most recent fiscal year, he said, Medi-Cal patients comprised 26% of 336,600 inpatient days and 34% of 156,000 emergency department visits. "UCLA Health's long-standing commitment to serving vulnerable populations in Southern California is well-established," he said. Aug. 3, 2026 Hampton said the net patient service revenue data doesn't reflect the complexity of care delivered by UCLA and is affected by Medi-Cal reimbursement rates and payment policies, which vary by region and health plan. "Over time, Medi-Cal reimbursement has not kept pace with the cost of providing care, and UCLA Health has experienced increasing payment denials and delays," he said. UCLA specialists had been caring for Health Care LA's seriously ill patients under the contract since 2009. "They were the provider that did all the complicated care," Matovsky said. "UCLA was our go-to." More to read. Inside the business of entertainment. The Wide Shot brings you news, analysis and insights on everything from streaming wars to production - and what it all means for the future. By continuing, you agree to its Terms of Service, which include arbitration and a class action waiver. You agree that Prospering In America, Inc. and its third-party vendors may collect and use your information, including through cookies, pixels and similar technologies, for the purposes set forth in its Privacy Policy such as personalizing your experience and ads. Melody Petersen is an investigative reporter for the Los Angeles Times, writing about business and healthcare. Send her tips securely on Signal at (213) 327-8634.
SLIViT and the rise of efficient multimodal 3D medical imaging AI. September 3, 2026 - LotusChain R&D On September 3, 2026, UCLA Health researchers publicly detailed SLIViT (SLice Integration by Vision Transformer), a deep-learning framework that achieves clinical-expert-level accuracy across multiple volumetric imaging modalities while dramatically reducing both training data requirements and inference time. SLIViT combines a Vision Transformer backbone with a specialized slice-integration mechanism and a self-supervised learning approach. The model has been validated on 3D optical coherence tomography (retinal disease risk biomarkers), ultrasound video (cardiac function), 3D MRI (liver disease severity), and 3D CT (chest nodule malignancy screening). In head-to-head comparisons it consistently outperformed domain-specific state-of-the-art models and matched the diagnostic accuracy of human specialists while reducing analysis time by a factor of approximately 5,000. A key practical advantage is data efficiency. Traditional volumetric models often require large, perfectly curated labeled datasets. SLIViT performs robustly on moderately sized and imperfectly ordered clinical datasets - the kind of data most hospitals actually possess. This lowers the barrier for startups building diagnostic tools outside of well-funded academic medical centers. The broader context is favorable. By the end of 2025 the FDA had cleared 1,451 AI-enabled medical devices, with radiology accounting for roughly 76 % of clearances and a record 295 new devices in 2025 alone. Multimodal and high-dimensional models are now moving from research papers into real clinical pipelines. Complementary advances such as Google's MedGemma 1.5 (expanded support for 3D CT/MRI volumes and whole-slide histopathology) and the growing body of evidence from large mammography RCTs (e.g., MASAI trial showing AI-supported screening detecting 29 % more cancers with reduced radiologist workload) reinforce the same direction. For founders building in medical imaging, three implications stand out: * Data strategy over pure model size - Domain-adapted, efficient architectures that tolerate real-world data quality will outcompete larger generalist models that demand pristine labels. * Workflow integration is the new moat - Accuracy alone is no longer differentiating; the ability to plug into existing PACS/RIS workflows and deliver results in seconds rather than minutes is becoming decisive. * Regulatory readiness - With the FDA actively seeking input on generative and agentic AI frameworks (discussion paper issued August 2026), startups that design continuous performance monitoring and predetermined change-control plans from day one will move faster through clearance. SLIViT is one concrete data point in a larger shift: efficient, multimodal 3D imaging AI is leaving the research lab and entering production diagnostics. The startups that treat data efficiency, clinical robustness, and regulatory design as first-class product requirements will capture the next wave of value.
Nuclear medicine physician-scientist Dr. Amir Iravani joins UCLA Health to lead Theranostics Program. Dr. Iravani brings expertise in molecular imaging and radiopharmaceutical therapy to help expand research and clinical cancer care Dr. Amir Iravani will serve as director of the Theranostics Program and vice chair of clinical research in the department of nuclear medicine and theranostics. September 3, 2026 Dr. Amir Iravani, a nationally recognized nuclear medicine physician-scientist specializing in molecular imaging and targeted radiopharmaceutical therapies for patients with cancer, has joined UCLA Health where he will serve as director of the Theranostics Program and vice chair of clinical research in the department of nuclear medicine and theranostics. In his new roles, Iravani will work with colleagues across the health system, including the David Geffen School of Medicine at UCLA and the UCLA Health Jonsson Comprehensive Cancer Center, to advance the integration of theranostics into cancer care, expand clinical trials and research opportunities and develop new collaborations in precision health. "I have followed UCLA's leadership in radiopharmaceutical therapy and molecular imaging for many years, so this opportunity was very consistent with what I wanted to do at the next stage of my career," said Iravani. "The establishment of an independent department of nuclear medicine and theranostics makes this an especially exciting time to join UCLA and help advance the field." Iravani brings extensive experience in theranostics, having trained at the Peter MacCallum Cancer Centre in Melbourne, Australia, a world-leading center in the field. More recently, he served as theranostics clinical director at Fred Hutchinson Cancer Center in Seattle and was an associate professor of radiology at the University of Washington School of Medicine, where he helped advance clinical care and research in molecular imaging and theranostics. Iravani has a distinguished record of research in molecular imaging and radiopharmaceutical therapy, with a focus on developing more personalized approaches to cancer treatment. His work spans across various malignancies, including neuroendocrine tumors, prostate cancer, and thyroid cancer. He studies how imaging biomarkers can be used to identify patients most likely to benefit from targeted therapies, optimize treatment schedules and monitor how tumors respond to treatment. His research has included the use of prostate-specific membrane antigen, or PSMA, imaging to guide radiopharmaceutical therapy for prostate cancer. PSMA PET imaging allows physicians to visualize the presence and distribution of PSMA-expressing prostate cancer throughout the body and can help identify patients who may benefit from PSMA-targeted therapies. More recently, Iravani has focused on further personalizing radiopharmaceutical therapy by using quantitative information from imaging, along with other biomarkers such as liquid biopsies, to determine the most appropriate dose and timing of treatment for individual patients. Iravani's vision for the UCLA program includes expanding theranostics beyond its current applications in prostate cancer and neuroendocrine tumors. He plans to help bring novel radiopharmaceutical therapies into clinical trials at UCLA and explore opportunities to develop treatment options for patients with additional solid tumors and hematologic malignancies. "The next step is integrating theranostics more fully into cancer care and expanding it beyond the diseases where we currently have approved treatments," said Iravani. "There are many novel agents in development, and I hope we can bring more of these early clinical trials to UCLA and give patients access to promising new treatments." The expansion will build on UCLA's longstanding leadership in molecular imaging and radiopharmaceutical therapy. The department of nuclear medicine and theranostics, which became an independent department in 2026, brings together clinical care, translational research, radiochemistry, preclinical research and clinical trials to accelerate the development of new diagnostic and therapeutic approaches. "Dr. Iravani brings a unique combination of clinical expertise and research innovation that will further strengthen UCLA's leadership in theranostics," said Dr. Johannes Czernin, acting chair of the department of nuclear medicine and theranostics. "His experience in developing personalized treatment strategies and conducting clinical research will help us expand the impact of this field and bring new options to our patients." UCLA has been a leader in advancing theranostics from discovery to patient care. Over the past decade, UCLA physician-scientists have pioneered advances in PSMA PET imaging and radiopharmaceutical therapy, including research that helped establish PSMA PET as an important tool for detecting prostate cancer throughout the body and supported the development of targeted radiopharmaceutical therapies now used to treat patients with advanced disease. For Iravani, the ultimate goal of advancing theranostics is to improve the lives of patients. "My major motivation is seeing patients benefit from the interventions we develop - improving their quality of life and, hopefully, their longevity," said Iravani. "I'm excited to work in a vibrant, collaborative environment where we can bring together people with the same goal of improving outcomes for patients." Book an appointment. See a doctor, virtually or in-person, with our easy online booking options. Articles: Services: Media contact. Denise Heady 310-948-3691
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Industries
Healthcare
Company Size
10,001+
Company Stage
Grant
Total Funding
$25.3M
Headquarters
Santa Monica, California
Founded
1955
Find jobs on Simplify and start your career today