Vor Bio

Vor Bio

Develops targeted therapies for blood cancers

Overview

Vor Biopharma focuses on developing therapies for blood cancers, especially AML, with a platform designed to protect healthy cells while targeting cancer cells. Its product approach centers on research and development of a proprietary treatment platform and a pipeline of therapies, funded through partnerships, licensing deals, and eventual commercialization after regulatory approval. The company differentiates itself by its emphasis on selectively sparing healthy cells, a collaborative cross-functional team led by experienced biopharma leaders (including founder Dr. Siddhartha Mukherjee), and a business model built on collaborations rather than solely internal sales. The goal is to transform blood cancer treatment by delivering therapies that minimize collateral damage to healthy tissue and bring effective treatments to patients through R&D, partnerships, and eventual market commercialization.

About Vor Bio

Simplify's Rating
Why Vor Bio is rated
C
Rated C on Competitive Edge
Rated B on Growth Potential
Rated D+ on Differentiation

Industries

Biotechnology

Healthcare

Company Size

51-200

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

2015

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Simplify's Take

What believers are saying

  • March 30, 2026 UPSTREAM SjD dosing expands into a huge underserved market.
  • June 2026 China approvals for Sjögren’s disease and IgAN broaden revenue credibility.
  • The August 2026 cash balance of $514.5 million funds operations into early 2029.

What critics are saying

  • If UPSTREAM MG fails in 1H27, Vor Bio loses its lead valuation driver.
  • Telitacicept still lacks U.S. approval; FDA rejection would crush partnering leverage.
  • The May 2025 95% workforce cut proves execution broke once; talent retention remains fragile.

What makes Vor Bio unique

  • Telitacicept blocks BLyS and APRIL, a dual-pathway autoimmune mechanism.
  • Vor Bio controls ex-China rights for telitacicept across gMG, SjD, and IgAN.
  • China approvals in 2026 validate the asset before U.S. commercialization.

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Funding

Total Funding

$1B

Above

Industry Average

Funded Over

9 Rounds

Private Placement VC funding comparison data is currently unavailable. We're working to provide this information soon!
Private Placement VC Funding Comparison
Coming Soon

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Paid Vacation

Parental Leave

401(k) Retirement Plan

401(k) Company Match

Commuter Benefits

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

1%

1 year growth

-18%

2 year growth

-3%
Associated Press
Aug 11th, 2026
Vor Bio reports $514.5M cash balance, expects runway into early 2029

Vor Bio reported second quarter 2026 financial results and provided updates on its clinical programmes for telitacicept, a dual BAFF/APRIL inhibitor for autoimmune diseases. The company reported a cash position of $466.1 million as of 30 June 2026. Combined with $48.4 million in net proceeds from July 2026 at-the-market sales, the pro-forma balance of $514.5 million is projected to fund operations into early 2029. Enrollment continues for the Phase 3 UPSTREAM MG trial in generalised myasthenia gravis, with topline results anticipated in the first half of 2027. Enrollment is also ongoing for the Phase 3 UPSTREAM SjD trial in primary Sjögren's disease. Telitacicept has received commercial approvals in China for treating Sjögren's disease and IgA nephropathy, bringing its total to five approved indications in the country.

Vor Bio
Jul 7th, 2026
Vor Bio appoints David Zaccardelli to Board of Directors.

Vor Bio appoints David Zaccardelli to Board of Directors. July 7, 2026 BOSTON, July 07, 2026 (GLOBE NEWSWIRE) - Vor Bio (Nasdaq: VOR), a clinical-stage biotechnology company transforming the treatment of autoimmune diseases, today announced the appointment of David Zaccardelli, Pharm.D., to its Board of Directors. With more than 20 years of biopharmaceutical leadership experience, Dr. Zaccardelli has successfully built and led companies through late-stage development, regulatory approval, and commercial launch. "We are excited to welcome David to the Board of Directors at an important stage in the company's evolution," said Jean-Paul Kress, M.D., Chairman and Chief Executive Officer of Vor Bio. "David is a proven biotech operator with a distinguished track record of leading companies through periods of significant growth, from late-stage development to commercial execution. His experience building organizations, launching medicines, and creating shareholder value will be invaluable as we advance telitacicept through global Phase 3 development and build a leading immunology company." Dr. Zaccardelli served as President, Chief Executive Officer, and on the board of directors of Verona Pharma from February 2020 until its acquisition by Merck for $10 billion in October 2025. During his tenure, Verona advanced from a clinical-stage company to a commercial-stage organization, successfully completing two Phase 3 trials, receiving FDA approval, and launching Ohtuvayre(R) for chronic obstructive pulmonary disease. Under his leadership, Verona raised more than $1 billion to support development and commercialization and became one of the top-performing biotechnology companies on Nasdaq in 2024 based on its five-year increase in market value. Dr. Zaccardelli was recognized as Executive of the Year at the 2023 Scrip Awards. Currently, he serves as Chair of the Board of Directors for SAB BIO and Founder and Managing Member of Bull City Select Investments, LLC. Prior to Verona, Dr. Zaccardelli served as President and Chief Executive Officer of Dova Pharmaceuticals, a rare disease company acquired by Swedish Orphan Biovitrum in 2019 for up to $915 million. He previously served as Acting Chief Executive Officer of Cempra through its merger with Melinta Therapeutics and held several senior leadership roles at United Therapeutics Corporation, including Chief Operating Officer, Chief Manufacturing Officer and Executive Vice President, Pharmaceutical Development and Operations. Earlier in his career, Dr. Zaccardelli founded and led a contract research start-up and held clinical research roles at Burroughs Wellcome, Glaxo Wellcome and Bausch & Lomb Pharmaceutical. He received a Pharm.D. from the University of Michigan and completed a fellowship in clinical research and drug development at the University of North Carolina. "Vor is at an exciting inflection point," said Dr. Zaccardelli. "Telitacicept has the potential to become an important therapy across multiple autoimmune diseases, and Vor has the team, capital and urgency to execute. I look forward to working with Jean-Paul, the Board, and the management team as the company advances telitacicept and enters its next phase of growth." In connection with Dr. Zaccardelli's appointment, Andrew Levin, M.D., Ph.D., an Advisor at RA Capital Management, has stepped down from Vor Bio's Board of Directors. "On behalf of the Board and management team, I want to thank Andrew for his leadership, counsel and commitment to Vor," said Dr. Kress. "Andrew has been an instrumental partner during a pivotal period of transformation for the company and we are grateful for his many contributions." About Telitacicept Telitacicept is a novel recombinant fusion protein designed to treat autoimmune diseases through dual inhibition of BLyS (BAFF) and APRIL - two cytokines essential to B cell and plasma cell survival. This dual-target mechanism reduces autoreactive B cells and autoantibody production, key drivers of autoimmune pathology. Telitacicept is approved in China for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), generalized myasthenia gravis (gMG), IgA nephropathy (IgAN), and Sjögren's disease (SjD). Vor Bio is advancing telitacicept in global Phase 3 trials in gMG and SjD to support potential regulatory approvals in the United States, Europe, and Japan. About Vor Bio Vor Bio is a clinical-stage biotechnology company transforming the treatment of autoimmune diseases. The Company is focused on rapidly advancing telitacicept, a novel dual-target fusion protein, through Phase 3 clinical development and potential commercialization to address serious autoantibody-driven conditions worldwide. For more information visit www.vorbio.com. Vor Bio routinely posts information that may be important to investors in the "Investors" section of its website. The Company encourages investors to consult that section of its website regularly. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The words "continue," "could," "design," "expect," "intend," "may," "ongoing," "plan," "potential," "should," "update," "will," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include Vor Bio's statements regarding telitacicept's potential to become an important therapy across multiple autoimmune diseases; Vor Bio's development and commercialization plans for telitacicept; Vor Bio's board of directors' transition; and other statements that are not historical fact. Vor Bio may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including that the data for its product candidates may not be sufficient for obtaining regulatory approval to commercialize products; Vor Bio, Inc. may not be able to execute its business plans, including meeting its planned clinical and regulatory milestones and timelines, and possible limitations of financial and other resources. These and other risks are described in greater detail under the caption "Risk Factors" included in Vor Bio's most recent annual or quarterly report and in other reports it has filed or may file with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Vor Bio expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise, except as may be required by law. Media & Investor Contacts: Carl Mauch [email protected]

Associated Press
May 13th, 2026
Vor Bio reports $491.5M cash balance, gMG trial results expected in 1H27

Vor Bio, a clinical-stage biotechnology company, reported first quarter 2026 financial results and announced its cash position of $491.5 million is expected to fund operations into early 2029. The company is advancing two Phase 3 trials of telitacicept, a dual BAFF/APRIL inhibitor. The UPSTREAM MG trial in generalised myasthenia gravis is on track with topline results anticipated in the first half of 2027, whilst enrollment continues for the UPSTREAM SjD trial in primary Sjögren's disease. Research and development expenses decreased to $17.6 million from $26.7 million year-over-year, primarily due to reduced spending on previous programmes. The company reported a net loss of $219.6 million for the quarter, compared to $32.5 million in the same period last year, mainly due to changes in fair value of outstanding liability-classified warrants.

Microsoft
Mar 27th, 2026
Vor Bio announces $75M private placement

Vor Bio (VOR) said on Friday it had entered a securities purchase agreement to sell 5.34M shares at $14.05 each in a private placement, for gross proceeds of about $75M. The private placement is expected to close on or about March 30, 2026. The financing is led by new investor TCGX. The net proceeds from the offering will be used for advancing teli...

StockTitan
Dec 23rd, 2025
Vor Bio Appoints RA Capital's Andrew Levin, M.D., Ph.D., and Forbion's Wouter Joustra to Board of Directors

Vor Bio appoints RA Capital's Andrew Levin, M.D., Ph.D., and Forbion's Wouter Joustra to Board of Directors. Rhea-AI summary. Vor Biopharma (Nasdaq: VOR) announced the appointment of Andrew Levin, M.D., Ph.D. of RA Capital and Wouter Joustra of Forbion to its Board of Directors on December 23, 2025. The appointments follow a $150M PIPE financing that included participation from both investors. Vor Bio said the new directors will support advancement of telitacicept through global Phase 3 programs and contribute to financing and governance strategy. Dr. Levin replaces Sarah Reed, who resigned from the Board. Both appointees are described as having deep life-sciences investment and late-stage biotech experience. * $150M PIPE financing completed with participation from RA Capital and Forbion * Board additions bring late-stage clinical and life-science investment expertise * Board support explicitly tied to advancing telitacicept global Phase 3 programs * Board turnover: Sarah Reed resigned and her seat is filled by Dr. Levin On the day this news was published, VOR declined 1.31%, reflecting a mild negative market reaction. Argus tracked a peak move of +17.4% during that session. Our momentum scanner triggered 24 alerts that day, indicating elevated trading interest and price volatility. This price movement removed approximately $8M from the company's valuation, bringing the market cap to $591M at that time. Data tracked by StockTitan Argus on the day of publication. BOSTON, Mass., Dec. 23, 2025 (GLOBE NEWSWIRE) - Vor Biopharma Inc. (Nasdaq: VOR), a clinical-stage biotechnology company dedicated to transforming the treatment of autoimmune diseases, today announced the appointment of Andrew Levin, M.D., Ph.D., Partner at RA Capital Management, and Wouter Joustra, General Partner at Forbion, to its Board of Directors. Their appointments follow the Company's recently announced $150M PIPE financing, which included participation from both investors. "Andrew and Wouter bring highly complementary experience in life sciences investment, financing strategy, and board-level oversight. We are delighted to welcome them to our Board at an important moment for the Company," said Jean-Paul Kress, M.D., Chief Executive Officer and Chairman of Vor Bio. "Their perspectives will be invaluable as we advance our global Phase 3 programs and position the Company to drive long-term shareholder value." Dr. Levin is a Partner on the investment team at RA Capital Management, L.P., where he brings deep expertise in life sciences investing and strategic oversight to support innovative biopharma companies across all stages of development. He holds a B.S. in mechanical engineering from Princeton University, and M.D. from Harvard Medical School, and a Ph.D. in biomedical engineering from Massachusetts Institute of Technology. Dr. Levin fills the seat previously held by Sarah Reed, General Counsel at RA Capital, who resigned from the Board. "Vor Bio is at an important inflection point, and I am excited to support the Company as it advances telitacicept through global Phase 3 development and continues to focus on disciplined capital allocation and long-term growth," said Dr. Levin. Mr. Joustra is a General Partner at Forbion, where he is responsible for general fund management, late stage private, cross-over and public investments. Mr. Joustra has served on the boards of several high-growth biotech companies through successful acquisitions and currently serves on the boards of multiple public and private life sciences companies. He holds an M.Sc. in Business Administration and a B.Sc. in International Business and Management from the University of Groningen. "Vor Bio has established an exceptionally strong foundation with telitacicept, and I look forward to contributing my experience in late-stage biotech growth and value creation as the Company scales its clinical programs," said Mr. Joustra. Vor Bio is a clinical-stage biotechnology company transforming the treatment of autoimmune diseases. The Company is focused on rapidly advancing telitacicept, a novel dual-target fusion protein, through Phase 3 clinical development and potential commercialization to address serious autoantibody-driven conditions worldwide. Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The words "aim," "anticipate," "can," "continue," "could," "design," "enable," "expect," "initiate," "intend," "may," "on-track," "ongoing," "plan," "potential," "should," "target," "update," "will," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include Vor Bio's statements regarding Vor Bio's development plans for telitacicept; and other statements that are not historical fact. Vor Bio may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors. These and other risks are described in greater detail under the caption "Risk Factors" included in Vor Bio's most recent annual or quarterly report and in other reports it has filed or may file with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Vor Bio expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise, except as may be required by law. Who were appointed to the Vor Biopharma board on December 23, 2025 (VOR)? Vor Biopharma appointed Andrew Levin, M.D., Ph.D. (RA Capital) and Wouter Joustra (Forbion) to its board. What capital raise is connected to Vor Biopharma's board appointments (VOR)? The appointments follow a $150M PIPE financing that included participation from RA Capital and Forbion. How will the new VOR board members affect telitacicept development? Company says the new directors will support advancing telitacicept through global Phase 3 programs and provide financing and governance guidance. Which board seat did Andrew Levin fill at Vor Biopharma (VOR)? Dr. Levin filled the board seat previously held by Sarah Reed, who resigned. What backgrounds do the new Vor Biopharma directors have (VOR)? Dr. Levin is a life-sciences investor with M.D./Ph.D. credentials; Mr. Joustra has experience in late-stage biotech investments and value creation.

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