POSITION SUMMARY:

The individual in this role will be responsible for leading and maintaining operations of a state-of-the-art flow cytometry facility. The candidate will serve as a subject matter expert to pre-clinical research and translational sciences teams and support high-dimensional analysis of cellular phenotypes, high-speed cell sorting, assay development, workflows, troubleshooting and data analysis to address a diverse set of hypotheses related to CAR-T biology. The incumbent will manage all operational aspects of flow cytometry lab such as instrument maintenance and reagent/materials ordering. In addition, this role will nurture relationships with key project leads and internal stakeholders to ensure effective communication, collaboration and achievement of enterprise-level research objectives.

KEY ROLES AND RESPONSIBILITIES:

• Partner closely with scientists in pre-clinical and translational teams to ensure the generation of high-quality, reliable, reproducible flow cytometry data through optimal panel design, assay development and analysis, while ensuring its positive impact on research objectives
• Ensure the maintenance of flow cytometry analyzers and sorters at peak operating condition by ensuring ongoing instrument maintenance, standardization, and quality assurance
• Manage/oversee research associates including mentoring, development, and training
• Ensure successful assay development, execution, and smooth operations of the flow core by maintaining antibody and other critical reagent inventory
• Responsible for writing and reviewing protocols and technical documents and ensuring quality standards are met in research laboratory setting
• Establish and standardize analysis strategies for flow cytometry-based assays and work with IT team for efficient data handling and storage
• Support cell sorting for downstream next-gen sequencing-based assays to enable deeper characterization of CAR-T cells in the context of complex in-vitro and in-vivo models
• Work closely and maintain productive relationships with process sciences team on complex flow cytometry assays for T cell characterization. Nurture productive and collegial relationships with all users
• Engage in continuing scientific and technical education so that the latest expertise knowledge is available to meet challenges in cutting-edge CAR-T research
• Train and assist new users with technical and operational procedures

PREFERRED EDUCATION:

• BSc in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 13 years’ experience or an 
• MSc in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 11 years’ experience or a
• PhD in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 6 years’ experience
• Demonstrated understanding of, and ability to apply principles, concepts, practices and standards associated with analytical flow cytometry assay development/validation, panel design, and/or sample testing in a laboratory setting.
• Proven experience in using high-dimensional multi-color flow cytometry instruments (Cytek Aurora preferable) and expert in multi-color panel design and analysis
• Expert in FlowJo and proven experience in analysis strategies for flow cytometry-based assays (knowledge of R scripting language considered a plus
• Demonstrated experience and understanding of techniques directly applicable to immune-oncology and/or CAR T research
• Must have excellent oral and written communication and presentation skills
• Must have critical thinking, high degree of ownership, strong organizational, and problem-solving skills and ability to quickly adapt to changing project
• Self-motivated and driven to achieve milestones and exceed goals with minimal direction
• Ability to work independently and collaboratively among cross-functional teams
• Ability to work efficiently, prioritize workflow, meet deadlines and balance competing priorities
• Excellent analytical skills and scientific/technical expertise

 

 

 

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

 

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.