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Associate Scientist
Gene Delivery Process & Analytical Development
Posted on 7/28/2022
INACTIVE
Locations
Seattle, WA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Desired Skills
Data Analysis
Writing
Requirements
  • M.S. or B.S. in Biological or Chemical Engineering, Virology, Molecular or Cellular Biology, Biochemistry, or related discipline
  • M.S. with 2 years of experience or B.S. with 4+ years of experience of process development experience with biological process unit operations and equipment (ie. mammalian cell culture, bioreactors, chromatography, normal flow filtration, tangential flow filtration, high-throughput automation) or equivalent experience
  • Experience developing and optimizing scalable, manufacturing-friendly upstream processes for the production or purification of biologics or viral vectors (lentiviral vectors and/or recombinant adeno-associated viruses) using equipment such as DASGIP bioreactors
  • Demonstrated independence in experimental design using design of experiment (DOE) principles followed by independent experimental execution and data analysis using statistical software (ex. JMP)
  • Proven ability to work in a fast-paced, multi-product, matrixed environment
  • Exceptional problem-solving and risk-based decision-making skills
  • Ability to communicate clearly and concisely through oral presentation and technical writing
  • Desire and drive to learn the biological mechanism of cell and gene therapy products and passion for their impact on the lives of patients with serious diseases
Responsibilities
  • Work in a collaborative, cross-functional team to develop robust, scalable recombinant adeno-associated virus (AAV) production and purification processes
  • Plan and execute experimental work in early or late-phase development and optimization of upstream (cell culture and transfection conditions) unit operations for viral vector production
  • Support tech transfer and on-going activities with external collaborators and service providers (CMOs, CROs)
  • Assist in the creation of next generation technologies and platforms for viral vector and gene editing manufacturing utilizing suspension cell culture, purification, and single-use systems
  • Provide technical and scientific mentorship to junior staff
  • Summarize and present scientific data; communicate progress to project teams
  • Author technical documents including protocols and internal development reports
  • Maintain a safe work environment in accordance with policies/procedures/regulations
Bristol-Myers Squibb

10,001+ employees

Biopharmaceutical development company
Company Overview
Bristol-Myers Squibb engages in the discovery, development, licensing, manufacturing, marketing, distribution and sale of pharmaceuticals.