Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Fall 2024 semester with experience in Biochemistry to join the RNA Technologies and Protein Sciences team. The candidate will be a part of the Protein Sciences team to produce and characterize Prime Editor proteins through various means to improve its therapeutic potential. This role will be highly collaborative and fast paced, so we are looking for a motivated team-player who is willing to continuously learn and be challenged. During your time at Prime Medicine you will hone your skills in research scale protein production, from gene to protein, as well as learn how we used cell based assays to evaluate activity.

Primary Responsibilities:

• Support protein production team needs by expressing and purifying proteins, including Prime Editors among others.
• Complex produced Prime Editor proteins with RNA components to build and characterize active complexes in both cell-free and cell-based contexts.
• Support Protein Science’s RNP delivery efforts in cells by implementing established cell culture techniques; including routine passaging, plating, transfections, and downstream workflows.
• Harvest genomic DNA and prepare libraries for next generation sequencing readouts
• Interpret, analyze and present data to internal and small team settings
• Keep up to date with documenting experiments in an electronic laboratory notebook (ELN)

Required Qualifications:

• B.S. candidate in Biochemistry or related major
• Basic knowledge of molecular biology and biochemistry
• Ability to troubleshoot by leveraging your understanding of key concepts
• Excellent written and verbal communication skills
• Committed to solving complex problems in a cross-functional collaborative environment

Preferred Qualifications:

• Experience with basic molecular biology techniques (PCR, cloning, etc.)
• Familiarity with aseptic technique and mammalian cell culture
• Previous experience and general understanding of basic protein expression and purification
• Keen attention to detail

What We Offer:

• A cutting-edge scientific team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular scientific seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.