Sr. Scientist, Immunology

Vancouver, WA (onsite)

We are seeking a highly motivated, collaborative, and innovative scientist to join our Disease Biology team within the Drug Creation department. The qualified candidate will have subject matter expertise in Immunology and a solid understanding of pathomechanisms of chronic inflammatory diseases. This individual will be responsible for helping to establish and expand our preclinical disease-relevant models and will lead development efforts defining our assets’ mechanism of action and efficacy in in-vitro/ex-vivo/in-vivo settings. They will actively contribute from the bench as well as manage CROs and be responsible for the development and conduct of in vitro, ex vivo and/or in vivo work packages to support and advance Absci’s drug discovery pipeline. The successful candidate will serve as Disease Biology SME on cross-functional drug development project teams, contributing biological, and disease area insights to projects as well as delivering on disease-relevant lead characterization work packages to advance the therapeutic program.  The successful candidate will demonstrate clear and professional communication, effectively collaborate with colleagues across a highly matrixed environment, and be capable of presenting scientific results to project teams. 

• Work in a dynamic and collaborative Disease Biology team that works closely with key stakeholders across our interdisciplinary R&D teams.
• Coordinate, design, organize & conduct preclinical in vitro, ex vivo and in vivo studies to advance our internal therapeutic programs.
• Generate, analyze, and interpret complex data, provide evaluation of PK-PD-efficacy relationships, exploration of PD and predictive biomarkers and elucidation of drug’s MoA.
• Identify and evaluate (new) in vivo models and technologies to enable novel target validation and lead discovery screening, perform lab-based activities to support a variety of research efforts towards MoA understanding and therapeutic lead development.
• Establish and manage interactions with vendors and CROs and work closely with key expertise areas to generate necessary studies and reagents for in vivo screening.
• Serve as Disease Biology SME on multiple project teams, conduct and trouble-shoot experiments, analyze and interpret data and work cross functionally with colleagues to identify and mitigate risks and effectively advance therapeutic programs
• Help build complex in vitro and ex vivo research and development capabilities
• Author and review clearly articulated SoPs, study reports, and data presentations.
• This position will be located at the Absci HQ in Vancouver, WA.

Required Qualifications

• Ph.D. or equivalent advanced degree in Pharmacology, Immunology/Inflammation, Oncology, Physiology, or related disciplines with at least 5+ years of post-PhD academic and / or industry experience in immunology, immune-mediated inflammatory diseases or related field establishing direct experimental experience with complex biology of inflammatory diseases
• Extensive experience with flow-based in-depth characterization of immune cell populations in blood and tissue samples.
• Experience with cell-based assays, ELISA, MSD, qPCR, microscopy, histology/pathology (e.g. IF/IHC/ISH).
• Demonstrated expertise with complex 2D/3D functional cell-based and tissue-based assays to investigate disease biology and PK/PD relationship.
•  Experience with leveraging complex data sets to characterize and establish a drug’s therapeutic mechanisms of action
•  Ability to be hands on and working in the lab, manage scientists, write protocols, execute studies leveraging Absci’s in house capabilities
• Experience working with project/research teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions
•  Ability to collaborate in writing protocols and reports
• Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
•  Detail-oriented and organized, with strong interpersonal skills for clear and effective communication

Preferred Skills and Experience

• Demonstrated record of leveraging in vivo pharmacology models to explore antibody-based drug discovery.
• Experience with therapeutics programs leading to drug candidate nomination in one or more of the following therapeutic areas: oncology, immunology / inflammation, metabolic diseases
• Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, and/or NDAs
• Experience working with complex patient-derived cell-based 2D/3D culture systems or ex vivo tissue models
• Ability to independently generate, analyze and interpret multi-omics data sets
• Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results
• Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams
• Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner

The salary range for this position (Sr. Scientist - Sr. Scientist II) is $127,000 - $165,000/year. Competitive equity package applies. Pay offered may vary depending on job-related knowledge, skills, and experience. In addition to equity, compensation packages include a wide range of medical, dental, vision benefits and ability to participate in our employee stock purchase plan.

Absci offers highly competitive salaries and benefits, including medical, dental, vision insurance, unlimited vacation, parental leave, breakfast and lunch for onsite employees, employee assistance program, voluntary life and disability insurance, annual bonus potential, and 401(k) with a generous company match.