Winter – Spring 2025 Co-Op

About the Job

We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.

*At this time, Sanofi will not sponsor a new applicant for employment authorization, or offer any immigration related support for this position (i.e. H1B, F-1 OPT, F-1 STEM OPT, F-1 CPT, J-1, TN, or another type of work authorization). **

Essential Duties and Responsibilities:

• The candidate is expected to learn how to use structural biology tools such cryo-EM and/or X-ray crystallography to elucidate antigen-antibody complex structures

• The candidate is expected to prepare negative staining EM samples and perform data collection and data analysis using cryoSparc or equivalent 

• The candidate will participate in the cryo-EM sample preparation & optimization, grid screening and data collection using cryogenic electron microscope (Glacios and Krios)

• The candidate will perform cryo-EM data processing using cryoSparc or equivalent and model building using Phenix, Coot and Isolde

• The work involves the interpretation of biochemical results of antigen-antibody complexes (ELISA, SPR, BLI etc)

• The work also involves the data analysis for protein quality (SEC, DSF, DSC etc)

• The candidate is expected to generate in-silico structural model using Alphafold or other protein modeling algorithms

• The candidate is expected to have a solution-focused, team-oriented mindset and will interact closely with other investigators in research and development of novel vaccine candidates 

• This is a hands-on, laboratory-based role in a highly collaborative research environment

• Role will require planning, designing, executing, interpreting, and presenting data in an effective and scientific manner

• Participate in scientific discussions focusing on current technology of structural biology

• Maintain detailed records and communicate progress and challenges, as necessary

• Perform timely electronic laboratory notebook entries, review and submission for completed experiments.

About you

Basic Qualifications:

• Currently pursuing a PhD in Molecular Biology, Biochemistry, Biophysics, Structural Biology, or closely related discipline

• Must have permanent US work authorization

• Must be able to relocate to our Waltham office location and complete the full duration on the Co-op 

• A background in structural biology is required

• Ability to independently design, plan and execute scientific studies, including operation and maintenance of relevant instruments and troubleshooting are required

• Strong interpersonal, communication, collaboration and problem-solving skills are needed

Preferred Qualifications:

• Experience with cryo-EM sample preparation and grid clipping is preferred 

• Experience with cryo-EM data processing and model building is preferred

• Deep knowledge and hands on experience with the biochemical and biophysical tools (SPR, BLI, DSF, SEC etc.) is preferred

• Advanced skill in structural viewing program such as Pymol and ChimeraX is preferred

• Familiarity with viral fusion protein and antibody biology is preferred

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Pursue progress, discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!