Full-Time

Scientist/Senior Scientist

Biological Analytical Development

Confirmed live in the last 24 hours

Zoetis

Zoetis

Mid, Senior

Kalamazoo, MI, USA

Category
Computational Biology
Biology Lab & Research
Biology & Biotech

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Degree
Experience
Requirements
  • PhD in Chemistry, Biochemistry, Computational Biology, or other related discipline, with at least 1-3 years of industry experience, preferably in the biopharmaceutical industry. BS or MS with extensive industry experience.
  • Motivated self-starter with excellent communication (oral and written), interpersonal, and organizational skills.
  • Extensive experience in separation technologies including multiple modes for HPLC and capillary electrophoresis (e.g., SEC, RP-HPLC, IEX, icIEF, CE-SDS) for the analysis of complex proteins.
  • Experience in developing, and validating biopharmaceutical analytical methods, including liquid chromatography (UHPLC and nano LC), electrophoretic separations, glycoprotein analysis, and mass spectrometry.
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
  • Solid understanding of protein structure, post-translational modifications (including glycans) and potential sequence liabilities (e.g oxidation, deamidation, and clipping).
  • Prepare comprehensive analytical reports and presentations, conveying findings to both technical and non-technical stakeholders.
  • Strong problem-solving skills and a proactive attitude toward process improvement.
Responsibilities
  • Characterization of biological molecules, identify degradation pathways, and define critical quality attributes. Contribute to analytical method development (including streamlining automation for samples preparation), qualification, validation and transfer activities. Primary techniques are HPLC, mass spectrometry, electrophoresis, spectrophotometric, and microplate assays.
  • Maintain familiarity with scientific literature and apply new knowledge appropriately to projects.
  • Convey complex and nuanced concepts to interdisciplinary teams through oral and written presentations, and reports.
  • Work in collaboration with other scientists to advance the development of state-of-the-art techniques to characterize biopharmaceutical products, assays, and tools. Develop high-throughput and/or automated methodologies for sample preparation.
  • Develop creative solutions to moderately complex problems.
  • Document and communicate results in laboratory notebooks, technical reports, and oral presentations.
Desired Qualifications
  • Proficiency in data analytics tools such as JMP, Tableau, and Minitab, with the ability to manipulate, analyze, and visualize complex data sets.
  • Familiarity with peptide mapping by LC-MS/MS (UHPLC and nanoLC), intact mass analysis, MS/MS for protein and carbohydrate structural elucidation.
  • Ability to recognize anomalous and inconsistent results and interpret outcomes.
  • Familiarity with biopharmaceutical manufacturing processes, including cell culture, purification, and formulation.
  • Skills and experience in experimental design, technical problem solving and continuous improvement; deepens technical knowledge through exposure and continuous learning.
  • Knowledge of regulatory guidelines such as ICH, USP, EMA or FDA.

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