Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.  Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Project Description:

Calico is seeking an energetic, enthusiastic and highly motivated Postdoctoral Fellow to join the Harding lab to work on a project at the intersection of immuno-oncology and aging biology. This work will complement our lab’s focus on uncovering new modalities for immunotherapy. The researcher will be deeply involved in understanding the interplay between aging, metabolism, immune system function, and cancer biology, utilizing state-of-the-art technologies and methodologies. The postdoc will receive comprehensive training and mentorship with a unique opportunity to collaborate with Calico’s diverse scientific community within the oncology, aging, and discovery technology groups.

Responsibilities:

• Conduct experimental research utilizing various tumor models, dietary interventions, immune cell depletion and adoptive transfer techniques
• Characterize immune-cell-intrinsic changes through phenotypic, transcriptional, and metabolomic analyses
• Investigate role of genes and pathways in modulating immune system function in vivo and in vitro primary cell culture using CRISPR modification, etc.
• Collaborate with interdisciplinary teams, including experts in immunology, aging, metabolism, and tumor biology, to integrate and expand research findings
• Publish and present research outcomes in scientific journals and conferences, contributing to the broader scientific community

Position Requirements:

• PhD in immunology highly preferred; PhD in cancer biology, molecular biology, or a related field acceptable
• Hands-on experience with in vivo techniques, including mouse handling/injection, tissue harvest, and isolation of immune cells
• Proficiency in standard molecular and cellular laboratory techniques such as flow cytometry, CRISPR, single-cell RNAseq, ELISA, Western Blot, primary cell culture
• Curiosity driven with strong analytical and critical thinking skills, with a capacity to conduct independent research
• Excellent spoken and written communication skills for effective collaboration and dissemination of research findings

Nice to Have:

• Technical expertise in the following areas: multi-color flow cytometry, primary immune cell culture, and mouse tumor models
• Experience with CRISPR screening technologies, working with genomics datasets, and/or competency in python/R-based data analysis
• Background in metabolism research (Seahorse, metabolomics data interpretation)

The estimated base salary for this role is $95,000.

More information on our postdoctoral fellowship program can be found here.