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Senior Scientist I
Aav, Process Development
Posted on 12/30/2022
INACTIVE
Locations
San Bruno, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • PhD degree in bioengineering, virology, cell biology, or a related field with 3 years of post-degree experience; OR Master's degree with 6 years of experience; OR Bachelor's degree with 8 years of experience
  • >1 year of hands-on experience in AAV vector production using bioreactors and suspension cells; >1 year of hands-on experience in AAV vector downstream processing including tangential flow filtration (TFF) and fast protein liquid chromatography (FPLC)
Responsibilities
  • Establish the upstream process of cell culture and AAV vector production in single-use or multi-use bioreactors. Optimize the downstream process of large-scale vector harvest, purification and formulation
  • Work closely with other members of the Viral Delivery Team to establish PD-related late-stage AAV analytics assays
  • Accurately and timely record, document, analyze and communicate laboratory data to senior staff and team members
  • Conduct all activities in a safe and efficient manner, and adheres to site environmental health and safety (EHS) requirements
  • Supervise research associates as needed
Desired Qualifications
  • Experience in AAV vector PD and regulatory policy for late-stage manufacturing
  • Experience in depth filtration (DF) of AAV crude lysates
  • Experience in ion-exchange (IEX) chromatography
  • Experience in AAV analytics assays for quantification of AAV titers, empty/full particle ratio, host cell impurities, and process-related impurities
  • Familiar with AAV vector biology and new vector design
  • Postdoc experience is preferred for PhD candidates
  • Experience with Benchling, Microsoft Office Suite and other data analysis software (SnapGene, GraphPad Prism, etc.)
  • Strong organizational and record-keeping skills
  • Excellent interpersonal, verbal and written communication skills
  • Highly motivated with strong work ethic
  • People management experience
Mammoth Biosciences

11-50 employees

CRISPR disease detection biotech company
Company Overview
Mammoth is on a mission to develop technologies and products with passion and that can have a mammoth impact. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple condition.
Benefits
  • Medical, dental, & vision
  • 401(k)
  • Unlimited vacation
  • Transportation subsidy
  • Onsite amenities
  • Happy hours
Company Core Values
  • Mission 1st
  • Innovation
  • Accountability
  • Execute with urgency
  • Inclusion & diversity