Full-Time

Senior Research Associate II

LNP Analytical Research and Development

Posted on 10/8/2024

Beam Therapeutics

Beam Therapeutics

501-1,000 employees

Develops precision genetic medicines using base editing

Biotechnology
Healthcare

Senior

Cambridge, MA, USA

Category
Bioinformatics
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis

You match the following Beam Therapeutics's candidate preferences

Employers are more likely to interview you if you match these preferences:

Degree
Experience
Requirements
  • B.S. degree in a relevant discipline (analytical chemistry, biochemistry, biotechnology, or related fields)
  • 6+ years (depending on title) industry experience (including biotech, biopharma, CRO, CDMO) with hands on experience in cell and gene therapy analytical development or QC
  • Hands on experience on analytical method development and sample testing at GMP or non-GMP environments
  • Knowledge of ICH/USP guidelines
  • Team player with excellent oral and written communication skills
  • Independently motivated, detail-oriented scientist with excellent critical thinking and problem-solving abilities
  • Excellent organizational skills towards multi-tasking in an extremely fast-paced environment with changing priorities.
Responsibilities
  • Develop and optimize analytical methods for RNA and LNP products to support Beam’s early and late phase method development requirements as well as establish platform analytical approaches
  • Execute analytical sample testing to support Beam’s internal and external development on LNP selection, optimization, production, and final DS/DP release and characterization
  • Work with cross-functional groups including LNP discovery, LNP process development, and LNP CMC team in various aspects of method development, transfer, characterization, comparability, and investigation
  • Support external testing labs as analytical SME
  • Generate materials to support assay feasibility test and GMP qualification at CDMOs, CROs, and internal GMP and non-GMP labs
  • Contribute to technical transfer of analytical methods both internally and to external vendors
  • Coordinate routine sample testing including requests from Process Development, Research and Development groups, and external vendors
  • Author and review SOPs, technical reports, and assist in the preparation of CMC regulatory submissions
  • Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance
  • Maintain detailed documentation of experiments in ELN system
Desired Qualifications
  • Experience with analysis of RNAs, lipids, and lipid nanoparticles (LNPs) is highly desirable and will be key to the success in this role
  • Working experience with at least one or several of the analytical techniques is required: HPLC (IPRP, SEC, IEX), capillary gel electrophoresis, fluorescence-based RNA quantitation. Experience with qPCR, DNA and RNA extraction, ELISA, UV spectrophotometry, DLS, MALS, mass spectrometry, and compendial testing will be a plus
  • Familiarity with data analysis software such as Empower, Openlab, Chromeleon, and statistical software such as JMP. Experience with LIMS system

Beam Therapeutics develops precision genetic medicines using a technique called base editing, which allows for precise modifications to the genetic code to potentially correct mutations that lead to serious diseases. Their primary focus is on treating genetic disorders, such as sickle cell disease, with the aim of providing lifelong cures rather than just temporary solutions. The company invests significantly in research and development to create new therapies and generates revenue through partnerships, licensing agreements, and future commercialization of their treatments. Unlike many competitors, Beam Therapeutics emphasizes collaboration with pharmaceutical companies and research institutions, which helps them secure funding and support for their projects. The ultimate goal of Beam Therapeutics is to advance scientific research and deliver effective, long-lasting treatments for patients suffering from genetic conditions.

Company Stage

IPO

Total Funding

$215.9M

Headquarters

Cambridge, Massachusetts

Founded

2017

Growth & Insights
Headcount

6 month growth

0%

1 year growth

-1%

2 year growth

0%
Simplify Jobs

Simplify's Take

What believers are saying

  • Base editing technology is gaining traction as a precise genetic correction method.
  • The $250 million deal with Eli Lilly boosts Beam's financial and strategic position.
  • Christi Shaw's appointment to the board brings valuable biotech leadership.

What critics are saying

  • Competition from CRISPR Therapeutics could impact Beam's market share.
  • Recent restructuring and layoffs may lead to operational challenges.
  • New CFO transition might pose financial management challenges.

What makes Beam Therapeutics unique

  • Beam Therapeutics uses base editing, a precise genetic correction method.
  • The company focuses on lifelong cures for genetic disorders like sickle cell disease.
  • Beam's strategic partnerships, like with Eli Lilly, enhance its market position.

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Benefits

Flexible Work Hours

INACTIVE