Full-Time

Principal Software Engineer

Updated on 9/4/2026

Aegis Ventures

Aegis Ventures

11-50 employees

Launches AI-driven health tech companies

Compensation Overview

$180k - $200k/yr

+ Equity

Remote in USA + 2 more

More locations: Cleveland, OH, USA | Columbus, OH, USA

Remote

Category
Software Engineering
Required Skills
Kubernetes
Distributed Systems
RDBMS
Infrastructure as Code (IaC)
Docker
AWS
Observability
HIPAA

Get referred to Aegis Ventures

See people who can refer or advise you

Requirements
  • At least 12 years of experience as an engineer across multiple technology stacks, with deep experience building and scaling distributed systems.
  • Ability to operate as a technical leader by setting direction, influencing others, and delivering results without formal authority.
  • Strong foundation in software engineering best practices, including continuous integration and continuous delivery, observability, automated testing, and infrastructure as code.
  • Experience with cloud-native systems, preferably Amazon Web Services, including containerization with Docker and Kubernetes.
  • Knowledge of relational and non-relational databases.
  • Demonstrated success in a highly regulated environment, preferably healthcare, with an understanding of compliance and data protection such as HIPAA.
  • Ability to represent engineering in executive conversations and product strategy.
  • Ability to teach, mentor, and cultivate a high-trust, high-autonomy team environment.
Responsibilities
  • Architect and lead the development of critical systems, services, and infrastructure, focusing on reliability, security, performance, and maintainability.
  • Partner with product and program leaders to align engineering solutions with user needs, regulatory requirements, and business outcomes.
  • Set and evolve technical standards across the organization, proactively address technical debt, guide code review quality, and drive initiatives that improve team velocity and code quality.
  • Coach and mentor engineers across teams to help them grow their craft, navigate ambiguity, and develop their careers.
  • Investigate and evaluate new technologies to drive innovation, simplify complexity, and support scale.
  • Contribute directly to codebases, especially architectural foundations, prototypes, and complex or high-risk areas.
  • Identify gaps, facilitate collaboration, and unblock teams without taking over.
  • Uphold and strengthen the engineering culture.
  • Help recruit and onboard exceptional talent.
Desired Qualifications
  • Experience with cloud-native systems, preferably Amazon Web Services.
  • Experience in healthcare or another highly regulated environment.

Aegis Ventures is a startup studio that partners with entrepreneurs and industry leaders to originate, launch, and scale new companies focused on AI and health tech. It operates a platform that combines market-shaping ideas, permanent growth capital, and ambitious people to identify opportunities, fund them long-term, and provide hands-on operational support. Unlike traditional funds, it creates companies in-house with a built-in path to rapid growth, with a strong emphasis on transforming healthcare quality, access, and cost. Its goal is to build companies capable of vast impact by using technology to improve health outcomes and societal wellbeing.

Company Size

11-50

Company Stage

N/A

Total Funding

$33.1M

Headquarters

New York City, New York

Founded

2020

Get referred to Aegis Ventures

See people who can refer or advise you

Simplify Jobs

Simplify's Take

What believers are saying

  • Wavelet secured $7 million on April 14, 2026, and is piloting at Yale and USC.
  • Optain acquired EyePACS in November 2025 and now serves 200 provider sites globally.
  • Aegis added Bunny Ellerin on April 6, 2026 and published a medtech AI whitepaper.

What critics are saying

  • Wavelet’s fetal EEG needs regulatory clearance and obstetric adoption before proving commercial demand.
  • Optain’s teleophthalmology rollout depends on reimbursement, workflow integration, and specialist validation.
  • Aegis’ public sites conflict on healthtech versus blockchain messaging, confusing talent and investors.

What makes Aegis Ventures unique

  • Aegis launched six healthtech companies by May 2026, pairing studio building with permanent capital.
  • Northwell, Yale, and Aegis give portfolio companies immediate clinical sites and enterprise buyers.
  • Aegis targets AI-native healthcare workflows, biomarkers, consumer care, and real-world data.

Help us improve and share your feedback! Did you find this helpful?

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Flexible Work Hours

Company Equity

Wellness Program

Mental Health Support

Company News

Yahoo Finance
Apr 14th, 2026
Yale-born fetal brain monitoring startup Wavelet secures $7M to prevent birth injuries

Wavelet Medical has secured $7 million in seed funding from Aegis Ventures to commercialise the first non-invasive, AI-powered fetal electroencephalography monitoring platform. The technology, developed at Yale, aims to detect fetal brain distress in real time and prevent avoidable brain injury at birth. Founded by Liz Golden, Dr Emily Lee and Dr Jose Cortes-Briones, Wavelet uses EEG captured through the mother's abdomen and reconstructed with AI algorithms to identify neurological distress, addressing limitations of traditional fetal heart rate monitoring, which is indeterminate in up to 85% of births. The platform targets a significant problem: over 35,000 infants suffer birth-related brain injuries annually in the US alone. Wavelet's partnership with Aegis Ventures will accelerate product development, clinical adoption and commercialisation of the technology.

PR Newswire
Apr 14th, 2026
Aegis Ventures and Wavelet Medical Aim to Redefine the Standard of Care in Fetal Medicine

/PRNewswire/ -- A breakthrough in fetal brain monitoring developed at Yale is moving from laboratory discovery to global commercialization through a pivotal...

Teknovation.biz
Nov 25th, 2024
News & Notes | Foundersforge Joins Village Capital’S Resource Iii Program For Entrepreneur Support Organizations

From Knoxville: The Knoxville Technology Council is asking local business representatives to complete its latest KTech Pulse 2024 Survey. Noting that the organization wants to get the pulse of Knoxville-area... The post News Notes | FoundersForge joins Village Capitals Resource III Program for Entrepreneur Support Organizations appeared first on Teknovation.biz.

Aegis Ventures
Oct 10th, 2023
Our Focus

We are driven by the mission to build companies that solve society's greatest problems, informed by the belief that the nexus of profits and purpose will create a virtuous cycle of impact that moves the world forward.

PR Newswire
Aug 22nd, 2023
Ascertain Announces Leadership Team With Appointment Of Ceo Mark Michalski, M.D. And Executive Chairman Gregg Fergus

Michalski, an Amazon alum, and Fergus, ex-CEO of 4Catalyzer, will lead the company creation platform building AI applications in healthcare.NEW YORK, Aug. 22, 2023 /PRNewswire/ -- Ascertain, a healthcare AI company creation platform, today announced the formation of its leadership team with the appointment of CEO Mark Michalski, M.D. and Executive Chairman, Gregg Fergus. Michalski and Fergus will lead Ascertain in its mission to merge deep technical, operational, and clinical expertise to deliver high-quality, equitable, and affordable healthcare.Michalski brings two decades of executive leadership experience to Ascertain. Prior to Ascertain, Michalski led strategic development for healthcare and life sciences at Amazon, was Founding Executive Director at Mass General Brigham/Harvard's Center for Clinical Data Science, and served as President and CMO of two publicly traded companies - Butterfly Network and Hyperfine Research. He is a board-certified radiologist and completed his medical training at Yale and Stanford.Fergus and Michalski met and collaborated closely at the venture studio 4Catalyzer where Fergus was CEO, launching several leading healthcare companies including Butterfly Network, Hyperfine Research, AI Therapeutics, and Quantum Si