Full-Time

Senior Medical Science Liaison

Multiple Teams

Posted on 8/15/2025

Sarepta

Sarepta

1,001-5,000 employees

Develops gene therapies for rare diseases

Compensation Overview

$200k - $250k/yr

No H1B Sponsorship

Houston, TX, USA + 1 more

More locations: Oklahoma City, OK, USA

Hybrid

Candidates must be located in the Texas or Oklahoma area.

Category
Medical, Clinical & Veterinary (1)
Requirements
  • MD, PhD, PharmD, or NP/PA preferred
  • 5+ years of MSL experience a plus
  • Familiarity with and track record of complying with industry and regulatory compliance guidelines
  • Demonstrated ability to work independently and in collaborative team environment
  • Existing Neurology / Pediatric experience and relationships is a plus, experience in immunology and/or gene therapy a plus
  • Willingness to travel >50% of time
  • Experience and expertise in clinical trial design, interpretation of scientific data, competitive intelligence tools, drug information systems, and medical marketing strategies
  • High integrity, sense of urgency, ability to recognize time sensitivity
  • Excellent written and verbal communication skills, exceptional listening skills, strong presentation skills, and good negotiating and influencing skills
Responsibilities
  • Identify, establish, and maintain collaborative relationships with key opinion leaders, investigators, and institutions within academic, clinical, and health care organizations in a defined territory
  • Implement KOL field strategy, KOL identification, speaker development, and support
  • Leadership role in medical education for healthcare professionals through proactive communication of scientific data as well as scientific exchange of information during routine interactions
  • High quality presentations of scientific data to health care professionals in various settings, including advisory boards, investigator meetings, and other appropriate venues to enhance product / disease state knowledge
  • Provide on-site support to clinical operations for investigators in ongoing clinical trials, investigator-initiated studies, and registries consistent with company objectives and regulations
  • Visit potential sites to assess their capabilities with regard to conduct these various forms of clinical research
  • Provide professional medical affairs representation and support at global, national and regional scientific meetings, including but not limited to staffing medical affairs booths, gathering competitive intelligence, and partnering with medical information to develop post-conference scientific materials
  • Develop and maintain clinical expertise in Duchenne muscular dystrophy through review of scientific journals, recent data disclosures and participation in scientific congresses
  • Demonstrate an understanding of key medical and commercial strategies and provide medical support for commercial activities.
Desired Qualifications
  • Existing Neurology / Pediatric experience and relationships is a plus
  • Experience in immunology and/or gene therapy a plus

Sarepta Therapeutics focuses on developing precision genetic medicines to treat rare diseases. It specializes in Duchenne muscular dystrophy (DMD) and is advancing gene therapies for limb-girdle muscular dystrophy (LGMD), Charcot-Marie-Tooth disease, MPS IIIA, and other CNS disorders. The company conducts research and development, carries therapies through clinical trials, and seeks regulatory approvals to bring treatments to patients, earning revenue from approved therapies and strategic partnerships. Its goal is to speed up drug development from lab research to patient treatment and to build the world’s largest gene therapy manufacturing capacity to meet global demand.

Company Size

1,001-5,000

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

1980

Simplify Jobs

Simplify's Take

What believers are saying

  • Enhanced immunosuppression regimen in ENDEAVOR Cohort 8 addresses acute liver injury safety concerns.
  • $700M convertible note refinancing and $600M credit facility improve financial flexibility.
  • Proof-of-concept readouts for DM1 and FSHD siRNA programs expected by Q1 2026.

What critics are saying

  • ELEVIDYS revenue declined 72.8% year-over-year in Q1 2026 to $101.97 million.
  • Another serious liver injury event triggers commercial hold and destroys launch credibility.
  • CEO Douglas Ingram retiring by end-2026 creates leadership vacuum during critical reset.

What makes Sarepta unique

  • EMBARK Phase III data shows 70-73% DMD progression slowing with 4.39-point NSAA improvement.
  • Exon-skipping platform AMONDYS 45 and VYONDYS 53 converting to traditional FDA approvals.
  • Pipeline expansion into DM1, FSHD siRNA, and Huntington's disease CNS disorders.

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Benefits

Wellness Program

Growth & Insights and Company News

Headcount

6 month growth

-5%

1 year growth

-5%

2 year growth

-5%
Yahoo Finance
Mar 23rd, 2026
Sarepta seeks FDA approval conversion for AMONDYS 45 and VYONDYS 53 using ESSENCE Phase 3 data

Sarepta Therapeutics has received FDA agreement to file supplemental applications by end of April seeking conversion of AMONDYS 45 and VYONDYS 53 from accelerated to traditional approvals, using data from the ESSENCE Phase 3 study and real-world evidence in Duchenne muscular dystrophy. The regulatory conversion could validate Sarepta's exon-skipping platform and strengthen its DMD franchise durability. However, the company faces ongoing safety concerns around its gene therapy ELEVIDYS. Sarepta is enrolling non-ambulant patients to test an enhanced immunosuppression regimen, with primary endpoints focused on acute liver injury incidence. The company's narrative projects $1.4 billion revenue and $171.6 million earnings by 2028, implying 17% annual revenue decline. Most optimistic analysts forecast $713.6 million earnings on $1.9 billion revenue by 2028.

Yahoo Finance
Mar 3rd, 2026
Bavarian Nordic CEO steps down amid pharma leadership shake-up

Bavarian Nordic has announced that CEO Paul Chaplin will step down after 11 years leading the Danish vaccine specialist, marking the latest executive change in pharmaceuticals this year. Chaplin, who joined in 2014, is leaving for personal reasons as his family relocates to Australia. He will remain until year-end or until a successor is found. The move follows recent departures elsewhere. Sarepta's Doug Ingram announced his retirement last month after a decade as CEO, citing family health concerns. Sanofi revealed in February it would not renew Paul Hudson's contract after six years, with share prices falling over 20% since February 2025. Belén Garijo, currently CEO of Merck KGaA, will take over at Sanofi from 29 April.

Yahoo Finance
Mar 1st, 2026
Wells Fargo cuts Sarepta Therapeutics price target to $38 from $45 after GTx launch delays

Wells Fargo has cut its price target on Sarepta Therapeutics to $38 from $45, maintaining an Overweight rating. The firm adjusted its ELEVIDYS projections, noting the gene therapy launch reset following safety events may take longer than anticipated based on 2026 guidance. However, Wells Fargo expects positive results from the company's siRNA readout. Separately, Baird reduced its price target to $20 from $22 with a Neutral rating following Sarepta's fiscal 2025 results. The company reported full-year net product revenues of $1.864 billion, comprising $965.6 million from PMO products and $898.7 million from ELEVIDYS. Sarepta Therapeutics develops RNA-targeted therapeutics and gene therapy for rare diseases, with several approved treatments for Duchenne muscular dystrophy.

Yahoo Finance
Feb 26th, 2026
Sarepta Therapeutics CEO Ingram to retire after tumultuous year for gene therapy Elevidys

Sarepta Therapeutics CEO Douglas Ingram will retire by the end of 2026 or upon appointment of his successor, the company announced in a regulatory filing. The firm has begun searching for his replacement. Ingram's departure follows a turbulent 2025 for the biotech company. Its gene therapy Elevidys, used to treat a muscle disorder, was linked to two patient deaths, prompting the FDA to request voluntary shipment halts. The company cut 500 jobs and halted development of several gene therapies. Elevidys carries the FDA's most serious safety warning and requires stringent monitoring. Despite the setbacks, Ingram said on Wednesday the therapy is on a potential pathway for expanded use. Sarepta's shares fell 82% last year and were down 4% in after-market trading. Ingram has led the company since 2017.

Yahoo Finance
Feb 26th, 2026
Sarepta posts $1.86B revenue, guides $1.2B–$1.4B for 2026 as CEO plans retirement

Sarepta Therapeutics reported 2025 net product revenue of $1.86 billion, comprising $966 million from its PMO franchise and $899 million from ELEVIDYS. The company guided 2026 approved-therapy revenue between $1.2 billion and $1.4 billion, whilst ending 2025 with $954 million in cash. Management described 2026 as a commercial "critical reset" for ELEVIDYS following two fatal events in 2025. Clinically, EMBARK three-year data showed a statistically significant 4.39-point NSAA benefit and approximately 70–73% slowing on key functional measures. Proof-of-concept readouts for DM1 and FSHD siRNA programmes are expected by end-Q1, with a Huntington's trial to begin in H1 2026. CEO Doug Ingram announced plans to retire around end-2026, with the board conducting a comprehensive successor search.

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