Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

This position is in the Analytical Development (AD) Group within the CMC Manufacturing Organization. An Associate Scientist III will support method development/validation activities for new drug substances and drug product. He/She will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. This position reports to either AD Management or Senior AD staff.

Responsibilities

Know and adhere to cGMP policies and procedures and relevant SOPs
Independently provide accurate analytical results in support of new and on-going projects
Independently meet project timelines and deliverables
Perform testing of samples to support batch release and stability studies
Perform portions of analytical techniques, such as HPLC, GC, FTIR, UV/Vis, LC/MS, KF, etc.
Assist with the design and initiation for development of analytical methods and improvement of existing ones to support all stages of drug development process
Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules
Evaluate and interpret scientific data and provide the significance of such
Independently design and execute non-routine experiments
Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up
Compile data tables of results, certificate of analysis, and develop stability reports
Write analytical test methods, protocols, and standard operating procedures
Calibrate, maintain, and troubleshoot all analytical equipment
Other duties as assigned

Requirements

B.S or M.S. in Chemistry (or related area of study)
At least 4 years of experience working in a chemistry laboratory setting
Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices
Ability to correctly analyze data/results and interpret outcome of experiments and to propose appropriate follow-up
Strong attention to detail
Works well with others and in a team environment
Can be flexible with changing priorities

Wisconsin pay range

$75,000—$85,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

California Applicant Privacy Policy

Associate Scientist

CMC Analytical Development

Arrowhead Pharmaceuticals

Compensation Overview

Simplify's Take

What believers are saying

What critics are saying

What makes Arrowhead Pharmaceuticals unique

Benefits