Full-Time

Senior Scientist

Cell Biology

Posted on 8/21/2024

Arcellx

Arcellx

51-200 employees

Develops immunotherapies for cell therapy

Biotechnology
Healthcare

Senior, Expert

North Bethesda, MD, USA

Relocation assistance is offered if required.

Category
Computational Biology
Genomics
Biology Lab & Research
Biology & Biotech
Requirements
  • Ph.D. with 2+ years of research experience within the pharmaceutical industry or post-doctoral experience within a relevant field. Candidates with a master’s degree and 5-8+ years research experience within the pharmaceutical industry will also be considered.
  • Specific backgrounds of interest are: Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics, T-cell signaling and/or cytokine signaling and cytokine biology, Solid Tumor Immunology (Tumor Infiltrating Lymphocytes, Myeloid Derived Suppressor Cells, Tumor Associated Macrophages, Regulatory T-cells)
  • Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion.
  • Expertise in in vivo models of human cancer, including cell line derived xenografts and patient-derived xenografts.
  • Expertise in complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays (e.g. cytotoxicity, proliferation, degranulation), live cell analysis, and multiplex assays.
  • Proficiency in advanced analysis techniques for flow cytometry.
  • Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents.
  • Effective and timely communication of results and relevant scientific literature.
  • Commitment to ethical scientific investigations and rigorous experimental methods.
  • Ability and desire to multitask and function in a fast-paced entrepreneurial environment.
  • Interpersonal skills that promote a collaborative and productive lab environment.
Responsibilities
  • Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions.
  • Develop program strategy, driving the delivery of key pre-clinical data that support program progression.
  • Work independently and collaboratively, and effectively plan and organize work activities and prioritize task completion.
  • Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies.

Arcellx develops immunotherapies aimed at improving cell therapy for serious diseases. Their products work by harnessing the body's immune system to target and treat conditions that currently have limited treatment options. Unlike many competitors, Arcellx focuses specifically on proprietary immunotherapy products and has a business model that includes partnerships and licensing agreements to support their research and development efforts. The company's goal is to meet unmet medical needs by providing safe and effective treatment alternatives for patients.

Company Stage

IPO

Total Funding

$194.5M

Headquarters

Gaithersburg, Maryland

Founded

2014

Growth & Insights
Headcount

6 month growth

4%

1 year growth

0%

2 year growth

1%
Simplify Jobs

Simplify's Take

What believers are saying

  • Strategic partnership with Kite accelerates development and commercialization of therapies.
  • FDA support expedites approval process for Arcellx's innovative treatments.
  • Advancements in gene editing enhance precision of Arcellx's cell therapies.

What critics are saying

  • Competition from established CAR-T therapies like Abecma and Carvykti.
  • Dependency on Kite partnership could pose risks if dynamics change.
  • Phase 3 trial for anito-cel carries risk of not meeting endpoints.

What makes Arcellx unique

  • Arcellx's CART-ddBCMA has FDA Fast Track, Orphan Drug, and RMAT designations.
  • The ARC-SparX platform offers dosable and controllable CAR-T therapy options.
  • Anito-cel uses a novel D-Domain BCMA binder for enhanced antigen binding.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Unlimited Paid Time Off

Flexible Work Hours

401(k) Company Match

Fully-Paid Parental Leave

Tuition Reimbursement

Relocation Assistance

INACTIVE