Simplify Logo

Full-Time

Senior Scientist

Cell Biology

Confirmed live in the last 24 hours

Arcellx

Arcellx

51-200 employees

Develops cell therapies for cancer, autoimmune diseases

Hardware
Biotechnology

Senior, Expert

North Bethesda, MD, USA

Category
Computational Biology
Genomics
Biology Lab & Research
Biology & Biotech
Requirements
  • Ph.D. with 2+ years of research experience within the pharmaceutical industry or post-doctoral experience within a relevant field. Candidates with a master’s degree and 5-8+ years research experience within the pharmaceutical industry will also be considered.
  • Specific backgrounds of interest are: Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics, T-cell signaling and/or cytokine signaling and cytokine biology, Solid Tumor Immunology (Tumor Infiltrating Lymphocytes, Myeloid Derived Suppressor Cells, Tumor Associated Macrophages, Regulatory T-cells)
  • Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion.
  • Expertise in in vivo models of human cancer, including cell line derived xenografts and patient-derived xenografts.
  • Expertise in complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays (e.g. cytotoxicity, proliferation, degranulation), live cell analysis, and multiplex assays.
  • Proficiency in advanced analysis techniques for flow cytometry.
  • Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents.
  • Effective and timely communication of results and relevant scientific literature.
  • Commitment to ethical scientific investigations and rigorous experimental methods.
  • Ability and desire to multitask and function in a fast-paced entrepreneurial environment.
  • Interpersonal skills that promote a collaborative and productive lab environment.
Responsibilities
  • Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions.
  • Develop program strategy, driving the delivery of key pre-clinical data that support program progression.
  • Work independently and collaboratively, and effectively plan and organize work activities and prioritize task completion.
  • Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies.

Arcellx develops innovative cell therapies for cancer and autoimmune diseases, leveraging their novel D-Domain technology and transformative ddCAR and ARC-SparX platforms to enhance cell therapy.

Company Stage

N/A

Total Funding

$736M

Headquarters

Gaithersburg, Maryland

Founded

2014

Growth & Insights
Headcount

6 month growth

16%

1 year growth

25%

2 year growth

76%
Simplify Jobs

Simplify's Take

What believers are saying

  • The Phase 3 iMMagine-3 trial for anito-cel could significantly boost Arcellx's market position if successful.
  • Recent robust long-term responses from the Phase 1 expansion trial of anito-cel indicate promising efficacy and safety, potentially leading to FDA approval.
  • The $285M equity investment and upfront cash from Kite provide substantial financial backing for Arcellx's ongoing and future projects.

What critics are saying

  • The competitive landscape for CAR T therapies is intense, with established players like Abecma and Carvykti posing significant challenges.
  • Regulatory hurdles, such as the recent FDA partial hold, could delay product development and market entry.

What makes Arcellx unique

  • Arcellx's anitocabtagene autoleucel (anito-cel) is the first BCMA CAR T therapy for multiple myeloma utilizing a novel D-Domain binder, setting it apart from existing treatments.
  • The company's strategic partnership with Kite, a Gilead Company, enhances its research capabilities and market reach, distinguishing it from smaller biotech firms.
  • Arcellx's focus on innovative immunotherapies for cancer and other incurable diseases positions it uniquely in the biotech landscape.