Scientist – Antibody Discovery & Characterization

Onsite 3 days per week at our Boston Seaport headquarters.

We are seeking a creative and experienced Scientist with a strong background in bispecific and multi-specific antibody engineering to join our Antibody Developability team. This individual will be a key contributor to the design, production, and in-depth characterization of novel therapeutic antibody formats, including IgGs, VHHs and scFv-based constructs. The ideal candidate will leverage their expertise in protein engineering and state-of-the-art developability assays and play a critical role in advancing our high-throughput antibody developability platform, PROPHET-Ab.

Key Responsibilities

• Lead the design and engineering of novel antibody formats, including bispecific and multi-specific constructs, to optimize for function and developability.
• Develop and execute workflows for the production (transfection, expression) and purification of complex antibody formats.
• Design and implement a wide range of biophysical and functional assays to evaluate antibody binding, stability, and activity, with a focus on challenges unique to bi/multi-specifics, VHHs, and scFvs.
• Develop methods for developability assessments for novel antibody formats (such as bi/multi-specifics), as well as binding kinetics (SPR/BLI), and functional cell-based assays.
• Provide technical leadership and hands-on expertise to troubleshoot expression, purification, and analytical challenges associated with novel formats.
• Contribute to scientific strategy, innovation, and the continuous improvement of our developability assessment platform.
• Mentor and guide junior scientists.
• Author technical reports, SOPs, and present findings to internal leadership and external customers.

Required Qualifications

• Ph.D. in Biochemistry, Immunology, Bioengineering, or a related field with 0-2 years of industry/academic experience (or M.S. with 6+ years or B.S. with 8+ years of relevant experience).
• Deep expertise in the design, engineering, expression, and characterization of complex protein formats, with a demonstrated track record working with bispecific or multi-specific antibodies.
• Demonstrated proficiency in antibody developability assessment using multiple biophysical techniques (e.g., DSF, DLS, SEC, HIC, AC-SINS, Polyreactivity).
• Extensive hands-on expertise with SPR (e.g., Biacore) or BLI (e.g., Octet) for quantitative analysis of complex binding interactions, such as simultaneous binding of bispecifics.
• Proven ability to independently lead projects and contribute to experimental design.
• Excellent communication skills and the ability to thrive in a highly collaborative, multidisciplinary environment.

Preferred Qualifications

• Industry experience in therapeutic antibody discovery and development.
• Experience with or exposure to computational tools for antibody discovery, including the use of AI/ML models for in silico developability prediction or sequence optimization.
• Familiarity with high-throughput expression, purification, and screening techniques.
• Knowledge of antibody display platforms (e.g., phage, yeast) or other discovery methods is desirable.