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Senior Associate Scientist
Molecular and Cellular Pharmacology Oncology
Posted on 9/9/2022
Cambridge, MA, USA
Experience Level
  • Bachelor's Degree
  • Master's Degree
  • Develop and implement relevant cell-based and biochemical assays to support identification (through high-throughput screenings), optimization, and characterization of novel chemical matter
  • Develop and construct cell lines and tools for MoA studies
  • Design and conduct critical experiments using expertise in cell biology, molecular biology, Biochemistry and assay development to support SAR and MoA studies
  • Analyze and present data in an organized and timely manner
  • Support biology needs for different projects and drug discovery teams
  • Works within established procedures and in loosely defined problem-solving situations
  • Makes decisions that require choosing between limited alternatives to resolve problems of varying levels of complexity
  • Actively participates in troubleshooting of routine problems and initiatives related to continuous improvement or development of new approaches / technologies
  • Coordinates activities with other team members to achieve results
Desired Qualifications
  • Familiarity with discovery of new small molecule entities and lead identification/optimization. Understand key aspects of SAR support using biological assays
  • Deep understanding and willingness to learn molecular and cellular assays, including but not limited to: Molecular cloning, cell proliferation assays, IncuCyte growth, cell cycle assays, apoptosis assays, imaging, MSD, and FACS
  • Experience in mammalian cell culture, lentivirus preparation, transfection of cell lines, CRISPR, shRNA knock downs, and Western blot analysis
  • Familiarity with genome-wide screening techniques and genomics including RNAseq is a plus
  • Ability to use or learn automation equipment and develop assays in 96 or 384-well formats
  • Excellent communication, presentation, collaboration, and organizational skills
  • Capability to stay focused, attention to details and deliver high quality data in a timely and well-organized manner
  • Ability to handle multiple projects and work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude
Bristol-Myers Squibb

10,001+ employees

Biopharmaceutical development company
Company Overview
Bristol-Myers Squibb engages in the discovery, development, licensing, manufacturing, marketing, distribution and sale of pharmaceuticals.