Full-Time

Senior Principal Scientist – Cellular Pharmacology and Lead Discovery

Confirmed live in the last 24 hours

MSD

MSD

Compensation Overview

$184.8k - $290.9kAnnually

+ Bonus Eligibility + Long Term Incentive

Senior, Expert

H1B Sponsorship Available

San Bruno, CA, USA

Hybrid work requiring three days on-site per week.

Category
Physicians & Surgeons
Medical, Clinical & Veterinary
Required Skills
Data Science
Requirements
  • Ph.D. in Pharmacology, Cell Biology, Immunology or related discipline and relevant industry experience listed below
  • A minimum of 15 years of drug discovery experience at a biotech or pharmaceutical setting in obesity, dysmetabolism, diabetes and cardiovascular complications, with demonstrated quantitative pharmacology expertise
  • Proficiency in drug discovery strategies and processes throughout target identification and validation, lead optimization, preclinical candidate selection, and early development
  • Highly skilled in complex cell-based assays/models for biomarker discovery and translation, utilization of lab automation, and deep expertise in mechanistic pharmacology
  • Experience leading discovery teams, setting strategy & priorities, and managing resources
  • An excellent track record of providing mentorship to direct reports and influencing peers
  • Ability to work collaboratively in a cross-functional team environment to shape strategy and tactics and drive rapid pipeline progression toward key milestones
  • Solid data science and analytical skills, as well as excellent written and oral communication
  • A strong record of publication in peer-reviewed journals and/or patent literatures
Responsibilities
  • Develop and support comprehensive pharmacology strategies targeting obesity, immuno-metabolic, and cardiovascular diseases to enable a robust drug discovery pipeline
  • Drive hit/lead finding and lead optimization plans in collaboration with therapeutic area stakeholders, Chemistry, Biologics, and multidisciplinary teams
  • Lead the development and implementation of potency, selectivity, and mechanistic assays to characterize molecules targeting diverse targets and areas of biology
  • Lead the design and execution of complex models utilizing physiologically relevant cellular systems and advanced technologies
  • Serve as a core member in matrixed project teams and governance committees to guide pharmacology strategy and provide scientific and technical leadership
  • Ensure high-quality data generation, analysis, and reporting to project teams, governance bodies, and regulatory agencies, and manage key timelines and milestones
  • Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies to enhance functional capability and productivity
  • Monitor emerging biology, biomarker, as well as basic & clinical research in cardiometabolic disorders to influence portfolio development strategy
  • Collaborate extensively across our network and with external partners to drive pipeline progression toward key milestones

Company Stage

N/A

Total Funding

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Headquarters

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Founded

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