Senior Scientist

Salary Range: 120000 to 180000 (Currency: USD) (Pay period: per-year-salary)

Key Responsibilities

• Develop clinically translatable healthy in vitro models using primary/immortalized cardiac cells, including iPSC-derived cardiomyocytes
• Design and implement high throughput screening (HTS) experiments to characterize the viability and functional performance of cardiac cells using MEA, calcium imaging, impedance-based readouts
• Create and validate complex in vitro 3D cardiac models (e.g., organoids, engineered heart tissues, micro-tissues) to accurately assess cardiotoxicity and permeability of new cryoprotectant solutions
• Develop innovative approaches to characterize cardiotoxicity of new compounds and their interactions with healthy heart function, including functional endpoints such as contractility, electrophysiology, and calcium handling
• Apply plate-reader, flow cytometry based and/or genomics techniques such as GWAS, RNAseq, and FISH to inform and refine molecular discovery and in vitro models
• Collaborate closely with cross-functional teams to translate experimental findings into new cryoprotectant solutions for human-sized organ preservation
• Recruit and mentor team members and take on greater responsibility for experimental design and strategy as needed

Who You Are

• PhD and/or Postdoc training in Cardiac Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, Pharmacology, Toxicology or a related field, or have an equivalent (4+ years) of industry experience leading research projects end-to-end
• Have a track record of scientific excellence and autonomy, with the ability to independently develop and carry out complex experiments in cardiac biology or a related therapeutic area
• Hands-on expertise in cell-based assay development, including experience with primary cells, iPSC-derived cell types, or 3D in vitro models
• Proven ability to design and execute high throughput screening workflows and analyze multiparametric datasets
• Bring a collaborative mindset and value diverse perspectives
• Thrive fast-paced environments with high sense of mission and urgency
Nice to have
• Experience evaluating pharmacokinetics and pharmacodynamics, with the ability to apply these frameworks to cryoprotectant formulation development
• Experience with cardiac electrophysiology, contractility measurement, or calcium imaging techniques
• Publication record in peer-reviewed journals in cardiac biology, cryobiology, toxicology, or related fields

Benefits

• Opportunity for outsized impact creating the future as an early team member
• Generous medical, dental, and vision insurance coverage for employees and their dependents
• Flexible time off and paid holidays
• Competitive compensation package, including salary and equity
• Access to a 401(k) retirement savings plan
• FSA and commuter benefits
• Subsidized lunch daily