Full-Time

Scientist I/II

Complex Ex Vivo Systems

Confirmed live in the last 24 hours

Gordian Biotechnology

Gordian Biotechnology

11-50 employees

Biotech startup focused on age-related diseases

Biotechnology
Healthcare

Compensation Overview

$115k - $150kAnnually

Junior, Mid

San Bruno, CA, USA

Position is onsite in South San Francisco, CA.

Category
Lab & Research
Life Sciences
Required Skills
Data Analysis
Requirements
  • experience in human ex vivo culture systems, specifically, with ex vivo human chondrocytes and knee joint explants (OA)
  • experienced in Cryosectioning tissues and RT-QPCR for gene expression in cell and tissue samples
  • experienced with ELISA, western blotting, enzymatic readouts, histology and image analysis (eg: ImageJ)
  • experience managing and collaborating on time-sensitive projects
  • comfortable guiding and collaborating across multiple teams to execute experiments at a scale beyond any single person
  • Experience working in industry and working with Lentiviruses/AAVs are both pluses.
Responsibilities
  • design and oversee ex vivo experiments to validate our screen results for our osteoarthritis (OA) disease program
  • architect experimental designs, set up new assays and evaluate the safety, efficacy, and mechanism of action of potential therapeutic targets
  • own an entire ex vivo validation project that aims at assessing the therapeutic efficacy of 10 or more treatments across 10 or more human donor samples
  • generate validation data in collaboration with other teams, analyze and present to stakeholders for decision-making
  • establish robust culture methods / delivery, generate validation data of multiple therapies
  • establish a medium-to-high throughput ex vivo validation process that feeds seamlessly into the in vivo validation pipeline
  • independently initiate another validation project with optimized data collection, organization and analyses
  • complete the first round of target validation for two ex vivo systems.
Gordian Biotechnology

Gordian Biotechnology

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Gordian Biotechnology focuses on developing treatments for age-related diseases through drug discovery. The company uses advanced technologies to create models that accurately reflect the complexities of aging, which helps in testing therapies in conditions similar to those in humans. This method increases the chances of success in clinical trials. Gordian Bio primarily collaborates with pharmaceutical companies, research institutions, and healthcare providers, generating revenue through partnerships and licensing agreements. Their goal is to extend healthy human lifespan by addressing the underlying causes of age-related diseases. They utilize animal models, like fruit flies, to study aging and test new therapies, which enhances the reliability of their research. The team consists of experts in gene therapy and genome engineering, and their work has been recognized at major industry conferences.

Company Stage

Seed

Total Funding

$58.4M

Headquarters

South San Francisco, California

Founded

1990

Growth & Insights
Headcount

6 month growth

2%

1 year growth

22%

2 year growth

65%
Simplify Jobs

Simplify's Take

What believers are saying

  • Growing interest in personalized medicine aligns with Gordian's predictive screening platform.
  • The age-related disease treatment market is projected to grow, benefiting Gordian's therapies.
  • Advancements in CRISPR technology could enhance Gordian's gene therapy research.

What critics are saying

  • Ethical scrutiny of animal models may impact Gordian's research methodologies.
  • Dependence on advanced technologies exposes Gordian to risks of obsolescence and supply chain issues.
  • Focus on niche age-related diseases could limit market reach and funding availability.

What makes Gordian Biotechnology unique

  • Gordian Bio uses advanced in vivo screening to predict age-related disease outcomes.
  • Their platform tests hundreds of gene therapies simultaneously, enhancing drug discovery efficiency.
  • Gordian's unique 'Patient Avatars' model human biology more accurately than traditional animal models.

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