Full-Time

Scientist I/II

Complex Ex Vivo Systems

Confirmed live in the last 24 hours

Gordian Biotechnology

Gordian Biotechnology

11-50 employees

Biotech startup focused on age-related disease therapies

Biotechnology
Healthcare

Compensation Overview

$115k - $150kAnnually

Entry, Junior, Mid

San Bruno, CA, USA

Position is onsite in South San Francisco, CA.

Category
Lab & Research
Life Sciences
Requirements
  • experience in human ex vivo culture systems, specifically, with ex vivo human chondrocytes and knee joint explants (OA)
  • experienced in Cryosectioning tissues and RT-QPCR for gene expression in cell and tissue samples
  • experienced with ELISA, western blotting, enzymatic readouts, histology and image analysis (eg: ImageJ)
  • experience managing and collaborating on time-sensitive projects
  • comfortable guiding and collaborating across multiple teams to execute experiments at a scale beyond any single person
  • experience working in industry
  • working with Lentiviruses/AAVs are both pluses
Responsibilities
  • design and oversee ex vivo experiments to validate screen results for osteoarthritis (OA) disease program
  • architect experimental designs
  • set up new assays
  • evaluate the safety, efficacy, and mechanism of action of potential therapeutic targets
  • manage experimental schedules
  • develop assays for in vivo and ex vivo workflows
  • set up ex vivo systems to drive forward validation plans for OA program
  • own an entire ex vivo validation project that aims at assessing the therapeutic efficacy of 10 or more treatments across 10 or more human donor samples
  • generate validation data in collaboration with other teams
  • analyze and present to stakeholders for decision-making
  • establish robust culture methods / delivery
  • generate validation data of multiple therapies
  • establish a medium-to-high throughput ex vivo validation process that feeds seamlessly into the in vivo validation pipeline
  • independently initiate another validation project with optimized data collection, organization and analyses
  • complete the first round of target validation for two ex vivo systems
Gordian Biotechnology

Gordian Biotechnology

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Gordian Biotechnology focuses on developing treatments for age-related diseases through drug discovery. The company uses advanced technologies to create models that accurately reflect the biological processes of aging, which helps in testing therapies in conditions similar to those in humans. This method increases the chances of success in clinical trials. Gordian Bio primarily collaborates with pharmaceutical companies, research institutions, and healthcare providers, generating revenue through partnerships and licensing agreements. Their goal is to extend healthy human lifespan by addressing the underlying causes of age-related diseases. They utilize animal models, like fruit flies, to study aging and test new therapies, allowing for scalable and precise research. The team consists of experts in gene therapy and genome engineering, and their work has been recognized at major industry conferences.

Company Stage

Seed

Total Funding

$58.4M

Headquarters

South San Francisco, California

Founded

1990

Growth & Insights
Headcount

6 month growth

2%

1 year growth

22%

2 year growth

65%
Simplify Jobs

Simplify's Take

What believers are saying

  • Focus on age-related diseases aligns with global interest in longevity.
  • Recent $60 million funding round boosts research and development efforts.
  • Strategic partnerships provide multiple revenue streams and collaboration opportunities.

What critics are saying

  • Increased competition from similar high-throughput screening platforms.
  • Potential ethical concerns over using animal models in drug testing.
  • Dependence on venture capital funding poses financial risks.

What makes Gordian Biotechnology unique

  • Gordian Bio uses 'patient avatars' for high-throughput in vivo screening.
  • Their platform achieves 80% predictive accuracy in proof-of-concept experiments.
  • Gordian Bio's proprietary Patient Avatars™ offer a unique competitive advantage.

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