Scientist II/ Senior Scientist

Ex Vivo Islet Biology and Metabolism, Gene Therapy Research

Posted on 4/27/2024

Fractyl Health, Inc

Fractyl Health, Inc

51-200 employees

Develops therapies for type 2 diabetes management


Mid, Senior

Burlington, MA, USA

  • PhD in Biology, Physiology, or relevant research field
  • Masters with 10+ years of industry experience in a highly related research field
  • 3-5+ years of highly relevant post-PhD experience in an academic or industry setting
  • Applicable experience in biotech and/or pharmaceutical industries preferred
  • Management and/or mentorship experience of associate scientists and/or scientists preferred
  • Extensive experience investigating and characterizing primary pancreatic islets [mouse and/or human] required
  • Experience in islet isolation (e.g., mouse, NHP, pig) preferred
  • Experience in mammalian cell culture and cell-based assays including beta-cell models
  • Experience working with various animal models of metabolic disease [e.g., db/db, DIO, MASH models]
  • Proficient in Flow Cytometry, Microscopy, IF imaging, ELISA and other immunochemical assays
  • Proficient in molecular biology techniques, such as DNA/RNA extraction, PCR, RT-PCR, Western Blot
  • Prior research in gene therapy approaches preferred
  • Experience with transfection and AAV transduction preferred
  • Experience working with CROs preferred
  • Experience in research that advances discovery programs to IND/CTA filing preferred
  • Design, optimize, and perform in vitro and ex vivo molecular assays
  • Contribute to in vivo data generation via the isolation and characterization of islets from treated animal models
  • Engineer the pancreas with properties that elicit relevant biological effects for disease targets
  • Identify and bring new technologies and key biological concepts and methods to support the gene therapy program
  • Manage relevant CRO activities including in vitro cell model development and assessment of islet transgene delivery, expression, and activity
  • Drive forward program goals to meet team objectives
  • Prepare technical reports, summaries, protocols, and quantitative analysis for experimental results
  • Mentor, train, and develop junior research scientists
  • Perform all activities in compliance with applicable regulations and Fractyl’s policies
  • Bring a 'can do' spirit to work and deliver on other responsibilities as assigned

Fractyl Health is pioneering Revita, an endoscopic procedural therapy that targets the root causes of type 2 diabetes by remodeling the duodenal lining via hydrothermal ablation. They are also developing Rejuva, a novel pancreatic gene therapy platform aimed at restoring insulin production and islet function in patients with advanced type 2 diabetes.

Company Stage


Total Funding



Lexington, Massachusetts



Growth & Insights

6 month growth


1 year growth


2 year growth